|1.||Bhujwalla, Zaver M: 16 articles (01/2016 - 06/2004)|
|2.||Glunde, Kristine: 13 articles (05/2014 - 06/2004)|
|3.||Lacal, Juan Carlos: 12 articles (01/2015 - 06/2002)|
|4.||Ramírez de Molina, Ana: 9 articles (01/2013 - 06/2002)|
|5.||Krishnamachary, Balaji: 7 articles (01/2016 - 04/2009)|
|6.||Mori, Noriko: 6 articles (01/2016 - 12/2005)|
|7.||Gallego-Ortega, David: 6 articles (01/2009 - 07/2005)|
|8.||Aboagye, Eric O: 5 articles (09/2015 - 10/2009)|
|9.||Cox, Gregory A: 5 articles (10/2011 - 02/2006)|
|10.||Sher, Roger B: 5 articles (10/2011 - 02/2006)|
02/15/2012 - "Imaging studies showed that the uptake of (18)F-D4-choline in three tumors with similar radiotracer delivery (K(1)) and choline kinase α expression-HCT116, A375, and PC3-M-were the same, suggesting that (18)F-D4-choline has utility for cancer detection irrespective of histologic type. "
10/01/2004 - "Further studies have to clarify whether quantification of the transport capacity or the choline kinase activity result in a better pathophysiological correlate and thus is the more useful process for tumor characterization."
01/01/2015 - "Preclinical characterization of RSM-932A, a novel anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells."
01/23/2014 - "Human choline kinase α (CKα) is a validated drug target for the treatment of cancer. "
11/01/2013 - "High choline kinase-α (Chk-α) expression is frequently observed in cancer cells, making it a novel target for pharmacological and molecular inhibition. "
|2.||Lung Neoplasms (Lung Cancer)
05/01/2015 - "Reverse transcription polymerase chain reaction and western blotting were used to investigate the expression of choline acetyltransferase (ChAT) and choline kinase α (ChoK) in lung cancer tissue and normal lung tissue. "
01/01/2014 - "The retrieved records show that choline kinase beta and glucose transporters were positively and significantly associated with lung cancer among the targets of 11C-choline and [18F]fluoro-2-deoxy-2-d-glucose (FDG), respectively. "
01/01/2013 - "The aim of this study was to investigate the efficacy of 11C-choline PET/CT imaging for lung cancer and the correlation between choline uptake of lung cancer tissue and the expression of choline kinase (ChoK), phosphorylcholine-cytidyl transferase and Ki-67 index. "
|3.||Breast Neoplasms (Breast Cancer)
01/01/2015 - "Choline kinase-α (Chk-α) and autophagy have gained much attention, as they relate to the drug-resistance of breast cancer. "
04/01/2012 - "Novel 4-amino bis-pyridinium and bis-quinolinium derivatives as choline kinase inhibitors with antiproliferative activity against the human breast cancer SKBR-3 cell line."
07/01/2010 - "Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells."
12/01/2009 - "Activation of choline kinase by extracellular Ca2+ is Ca(2+)-sensing receptor, Galpha12 and Rho-dependent in breast cancer cells."
05/01/2009 - "Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells."
|4.||Prostatic Neoplasms (Prostate Cancer)
09/01/2015 - "Exploiting altered patterns of choline kinase-alpha expression on human prostate tissue to prognosticate prostate cancer."
03/01/2015 - "Choline kinase is upregulated in prostate cancer, resulting in increased (18)F-fluoromethylcholine uptake. "
01/01/2012 - "To understand the mechanism behind this altered metabolic state, we examined the expression and regulation of the major choline kinase isoform, choline kinase α (ChKα), in hypoxic PC-3 human prostate cancer cells. "
05/01/2016 - "Among these, choline kinase alpha (CHKA) expression was evaluated in benign (n = 195), prostatic intraepithelial neoplasia (PIN) (n = 153) and prostate cancer (PCa) lesions (n = 359). "
11/01/2008 - "Using these methods on patients with prostate cancer, we found robust over-expression of choline kinase a in the majority of primary tumors. "
|5.||Hepatocellular Carcinoma (Hepatoma)
01/01/2012 - "Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival."
08/08/1989 - "The present study was undertaken to determine whether choline kinase in the murine hepatoma cell line, Hepa 1c1c7, is inducible by aromatic hydrocarbons and, if so, whether this induction is mediated by the aromatic hydrocarbon receptor. "
08/08/1989 - "The effect of polycyclic aromatic hydrocarbons on choline kinase activity in mouse hepatoma cells."
|1.||Choline (Choline Chloride)
|3.||Small Interfering RNA (siRNA)
|7.||Messenger RNA (mRNA)
|10.||Cytidine Triphosphate (CTP)
|1.||Heterologous Transplantation (Xenotransplantation)
|5.||Drug Therapy (Chemotherapy)