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Cholesterol 7-alpha-Hydroxylase (Cholesterol 7 alpha Hydroxylase)

A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
Also Known As:
Cholesterol 7 alpha Hydroxylase; CYP7; CYP 7; CYP 7A; Cholesterol 7-alpha-Monooxygenase; Cholesterol 7alpha-Hydroxylase; Cholesterol-7-Hydroxylase; Cytochrome P450 7; Cholesterol 7 Hydroxylase; Cholesterol 7 alpha Monooxygenase; Cholesterol 7alpha Hydroxylase; Cytochrome P 450 CYP7; CYP7A; Cytochrome P-450 CYP7; Cholesterol,NADPH:oxygen oxidoreductase (7 alpha-hydroxylating)
Networked: 119 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Vaziri, Nosratola D: 5 articles (12/2005 - 05/2002)
2. Liang, Kaihui: 4 articles (11/2004 - 05/2002)
3. Xue, Jie: 3 articles (09/2011 - 07/2007)
4. Zhang, Yan: 3 articles (09/2011 - 07/2007)
5. Shefer, Sarah: 3 articles (01/2004 - 12/2002)
6. Salen, Gerald: 3 articles (01/2004 - 12/2002)
7. Xie, Mei-Lin: 2 articles (09/2011 - 07/2008)
8. Chiang, John Y L: 2 articles (08/2010 - 11/2007)
9. Li, Tiangang: 2 articles (08/2010 - 11/2007)
10. Loria, P: 2 articles (03/2006 - 08/2001)

Related Diseases

1. Hypercholesterolemia
2. Gallstones (Gallstone)
3. Hyperthyroidism
4. Fistula
5. Dyslipidemias (Dyslipidemia)

Related Drugs and Biologics

1. Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)
2. Cholesterol
3. LDL Receptors (LDL Receptor)
4. Sterols
5. Vitamin A (Retinol)
6. Adenosine Triphosphate (ATP)
7. ATP binding cassette transporter 1
8. Bile Acids and Salts (Bile Acids)
9. Messenger RNA (mRNA)
10. Enzymes

Related Therapies and Procedures

1. Intravenous Infusions
2. Cholecystectomy
3. Aftercare (After-Treatment)
4. Oral Administration