|1.||Vaziri, Nosratola D: 5 articles (12/2005 - 05/2002)|
|2.||Liang, Kaihui: 4 articles (11/2004 - 05/2002)|
|3.||Xue, Jie: 3 articles (09/2011 - 07/2007)|
|4.||Zhang, Yan: 3 articles (09/2011 - 07/2007)|
|5.||Shefer, Sarah: 3 articles (01/2004 - 12/2002)|
|6.||Salen, Gerald: 3 articles (01/2004 - 12/2002)|
|7.||Xie, Mei-Lin: 2 articles (09/2011 - 07/2008)|
|8.||Chiang, John Y L: 2 articles (08/2010 - 11/2007)|
|9.||Li, Tiangang: 2 articles (08/2010 - 11/2007)|
|10.||Loria, P: 2 articles (03/2006 - 08/2001)|
07/01/2003 - "The observed up-regulation of cholesterol 7alpha-hydroxylase represents a compensatory response to the associated hypercholesterolemia. "
10/01/1993 - "Bile acid excretion and cholesterol 7 alpha-hydroxylase expression in hypercholesterolemia-resistant rabbits."
09/01/1985 - "These studies demonstrate 1) premature weaning on day 2 does not prevent neonatal hypercholesterolemia on day 5, 2) premature weaning causes a decrease in hepatic cholesterol 7 alpha-hydroxylase activity that persists into adult life, and 3) dietary cholesterol intake in early life is unable to negate premature weaning-induced changes."
12/01/2005 - "Thus the greater severity of hypercholesterolemia in the female NAR appears to be due, in part, to a combination of the constrained compensatory upregulation of cholesterol 7alpha-hydroxylase and LDL receptor deficiency."
10/01/2004 - "Hypercholesterolemia in diet-induced syndrome X is associated with depressed cholesterol 7alpha-hydroxylase, diminished LDL-R, elevated ACAT, and increased HMG-CoA reductase-to-cholesterol 7alpha-hydroxylase ratio. "
06/19/2009 - "Decreased expression of cholesterol 7alpha-hydroxylase and altered bile acid metabolism in Apobec-1-/- mice lead to increased gallstone susceptibility."
09/15/2006 - "These results suggest that Gpbar1 plays a critical role in the formation of gallstones, possibly via a regulatory mechanism involving the cholesterol 7alpha-hydroxylase pathway."
09/01/2005 - "Moreover, no association was observed between the CYP7AI promoter polymorphisms and the hepatic cholesterol 7alpha-hydroxylase activity and parameters of bile acid synthesis rates, as analyzed in subjects with gallstone disease. "
09/01/1975 - "Cholesterol 7 alpha-hydroxylase activity was reduced in the gallstone (47% lower) and biliary obstruction (78% lower) subjects. "
01/30/1998 - "Cholesterol 7 alpha-hydroxylase, the key enzyme in bile acid synthesis, has been implicated in atherosclerosis and gallstone disease. "
04/01/1997 - "Cholesterol 7 alpha-hydroxylase activity in hypothyroidism and hyperthyroidism in humans."
07/01/2008 - "The sterol content of bile, liver, and feces was markedly increased, accompanied by up-regulation of hepatic cholesterol 7alpha-hydroxylase, and ATP-binding cassette transporter 5, which is known to promote biliary sterol secretion upon dimerization with ATP-binding cassette transporter 8. Both control and hyperthyroid mice exerted identical plasma clearance of iv injected [(3)H]HDL-C, supporting the view that severe hyperthyroidism does not affect HDL-C clearance but, rather, its formation via hepatic ATP-binding cassette transporter 1."
04/01/1997 - "We determined serum concentrations of the bile acid precursor 7 alpha-hydroxy-4-cholesten-3-one, which reflects cholesterol 7 alpha-hydroxylase activity in the liver, in 19 patients with hypothyroidism and in 10 patients with hyperthyroidism before and after treatment, respectively. "
12/01/1990 - "The results of this study demonstrate that, in the chronic bile fistula rat, acute inhibition of cholesterol synthesis at either early or late steps leads to a rapid down-regulation of cholesterol 7 alpha-hydroxylase activity and decrease in bile acid synthesis."
08/01/1998 - "Bile fistula drainage stimulated cholesterol 7alpha-hydroxylase activity but not sterol 27-hydroxylase activity in all three rabbit groups. "
12/01/1990 - "In in vitro experiments using microsomes from livers of control bile fistula rats, the addition of AY9944 (up to 100 microM) failed to inhibit cholesterol 7 alpha-hydroxylase activity. "
04/01/1990 - "We studied the effect of the orientation of the 7-hydroxyl group in taurocholate (7 alpha) and tauroursocholate (7 beta) on the feedback regulation of bile-acid synthesis and its rate-controlling enzyme, cholesterol 7 alpha-hydroxylase, in bile-fistula rats. "
12/01/1990 - "Intravenous infusion of lymph into bile fistula rats led to a significant inhibition of both cholesterol 7 alpha-hydroxylase activity and HMG-CoA reductase activity. "
01/01/2008 - "Studies with different designs describe that for instance genes (and their variants) for cytochromes, apolipoprotein E and A1 and cholesterol 7alpha-hydroxylase may be important genetic determinants of the effect of pharmacological treatment of dyslipidemia and play a role in the individualisation of treatment."
02/01/2009 - "Multiple studies suggest increased conversion of cholesterol to bile acids by cholesterol 7alpha-hydroxylase (CYP7A1) protects against dyslipidemia and atherosclerosis. "
|1.||Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)
|3.||LDL Receptors (LDL Receptor)
|5.||Vitamin A (Retinol)
|6.||Adenosine Triphosphate (ATP)
|7.||ATP binding cassette transporter 1
|8.||Bile Acids and Salts (Bile Acids)
|9.||Messenger RNA (mRNA)