Cholesterol Esters (Cholesteryl Esters)

Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.

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Networked: 1623 relevant articles (32 outcomes, 120 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ghosh, Shobha: 10 articles (01/2018 - 10/2003)
2.	Rudel, Lawrence L: 9 articles (10/2014 - 08/2002)
3.	Chapman, M John: 9 articles (03/2012 - 03/2002)
4.	Dullaart, Robin P F: 8 articles (02/2019 - 01/2003)
5.	Liebisch, Gerhard: 7 articles (10/2021 - 02/2014)
6.	Ishibashi, Shun: 7 articles (11/2018 - 08/2002)
7.	Badimon, Lina: 7 articles (07/2017 - 06/2011)
8.	Tosi, M R: 7 articles (08/2004 - 01/2001)
9.	Tugnoli, V: 7 articles (08/2004 - 01/2001)
10.	Llorente-Cortés, Vicenta: 6 articles (02/2022 - 06/2011)

Related Diseases

1.	Atherosclerosis 07/01/2007 - "Previous studies in nonhuman primates revealed a striking positive correlation between liver cholesteryl ester (CE) secretion rate and the development of coronary artery atherosclerosis. " 12/01/2018 - "A bulk of cholesteryl esters accumulation in macrophage foam cells drives the occurrence and development of atherosclerosis. " 01/01/2018 - "Macrophage foam cells play critical roles in the initiation and development of atherosclerosis by synthesizing and accumulating cholesteryl ester (CE) in lipid droplets. " 01/01/2017 - "Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis." 05/01/2016 - "One of the first manifestations of atherosclerosis is accumulation of extra- and intracellular cholesterol esters in the arterial intima. "
2.	Insulin Resistance 05/01/2005 - "However, the increase in cholesteryl-ester turnover observed with OE treatment may be, at least in part, a consequence of the decrease in insulin resistance. " 11/01/2023 - "The specific blockage of cardiomyocyte cholesteryl ester (CE) loading by antibodies (Abs) against the P3 sequence (Gly1127-Cys1140) of the LRP1 receptor improves cardiac insulin sensitivity. " 10/01/2022 - "These findings suggest that orange juice has a positive impact on lipid metabolism, mainly regarding the composition of TG-specific fatty acid chains and cholesterol esters, protecting against insulin resistance. " 10/01/2004 - "The attenuated antioxidative activity of small, dense HDL subfractions correlated with systemic oxidative stress and insulin resistance and was associated with HDL particles exhibiting altered physicochemical properties (core triglyceride enrichment and cholesteryl ester depletion). " 10/01/1994 - "The peripheral insulin sensitivity was significantly and negatively correlated to the proportion of palmitic (r = -0.31, p < 0.001), palmitoleic (r = -0.25, p < 0.001) and di-homo-gamma-linolenic (r = -0.33, p < 0.001) acids and positively to the content of linoleic (r = 0.28, p < 0.001) acid in the serum cholesterol esters. "
3.	Inflammation (Inflammations) 04/01/2017 - "Oxidized cholesteryl esters and inflammation." 01/01/2017 - "Intrinsic aerobic capacity had no impact on WD-induced hepatic steatosis; however, rats bred for low aerobic capacity developed greater hepatic inflammation, which was associated with reduced hepatic mitochondrial FAO and respiratory capacity and increased accumulation of cholesterol esters. " 01/01/1999 - "Many studies have described the role of monocyte-derived macrophages (MDM) in inflammation leading to atherosclerosis, a process in which alterations in the metabolism of cholesterol esters is well established. " 05/01/2009 - "Ruptured plaques had, as also described for human plaques: i) marked medial and adventitial changes, including neovascularization and inflammation; ii) cholesterol monohydrate crystals and liquid crystalline cholesterol esters in the intima and the fibrous cap; and iii) inflamed, thin fibrous caps. " 12/01/2005 - "Our aim was to investigate the relations of FA composition in plasma phospholipids and cholesterol esters (CEs) with weight status, MS, and inflammation in adolescents. "
4.	Hypercholesterolemia 09/01/1992 - "Animal studies have demonstrated that hypercholesterolemia leads to the development of fibromuscular atherosclerotic lesions that are characterized by the intimal accumulation of cholesterol esters in macrophage foam cells and focal proliferation of smooth muscle cells (SMCs). " 11/01/1982 - "Studies have been performed on groups of mini-pigs 21-23 months of age, which after 18 months of hypercholesterolemia (approximately 10 mmol) had developed raised atherosclerotic lesions with high levels of cholesterol esters, especially in the abdominal aorta and the coronary arteries. " 04/01/1991 - "Accelerated cholesteryl ester transfer in plasma of patients with hypercholesterolemia." 01/01/1991 - "Cholesterol esters often deposit during hypercholesterolemia. " 02/01/1990 - "Cholesterol esters often deposit during hypercholesterolemia. "
5.	Xanthomatosis (Xanthoma) 02/01/1986 - "Hyperlipoproteinaemia and xanthomatosis as a model of cholesterol ester accumulation." 02/28/1985 - "Atherosclerotic lesions and xanthomas are characterized by the occurrence of cholesteryl ester (CE)-laden foam cells, which partly originate from macrophages. " 10/01/1978 - "The enthalpy (0971 +/- 0.07 cal/g) was reduced compared with the isolated cholesterol ester from each xanthoma (1.1+/-0.01 cal/g). " 10/01/1978 - "Scanning calorimetry of fresh pieces of xanthoma showed a single, broad, reversible liquid crystalline transition of cholesterol ester with peak temperature from 32 to 38 degrees C. " 07/14/2000 - "These results indicate that the local inhibition of ACAT activity in tissue macrophages is protective against cholesteryl ester accumulation but causes cutaneous xanthomatosis in mice that lack apo E or LDLR."

Related Drugs and Biologics

1.	Cholesterol
2.	Lipoproteins (Lipoprotein)
3.	oxidized low density lipoprotein
4.	Triglycerides (Triacylglycerol)
5.	Lipids
6.	Phospholipids (Phosphatides)
7.	LDL Lipoproteins (beta Lipoproteins)
8.	Nonesterified Fatty Acids (NEFA)
9.	Hydrolases
10.	Apolipoproteins E (ApoE)

Related Therapies and Procedures

1.	Boron Neutron Capture Therapy
2.	Aftercare (After-Treatment)
3.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
4.	Lasers (Laser)
5.	Drug Therapy (Chemotherapy)