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Cholesterol Side-Chain Cleavage Enzyme (CYP11A1)

A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
Also Known As:
CYP11A1; Cholesterol Monooxygenase (Side-Chain-Cleaving); 20,22-Desmolase; CYP 11A1; Cytochrome P450 11A1; Cytochrome P450scc; 20,22 Desmolase; Cholesterol Side Chain Cleavage Enzyme; Cytochrome P 450 CYP11A1; Cholesterol Desmolase; Cytochrome P-450 CYP11A1; Cytochrome P-450(scc); Cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
Networked: 108 relevant articles (0 outcomes, 16 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Li, Wei: 5 articles (07/2015 - 01/2010)
2. Slominski, Andrzej T: 5 articles (07/2015 - 01/2010)
3. Tuckey, Robert C: 5 articles (07/2015 - 01/2010)
4. Janjetovic, Zorica: 4 articles (05/2013 - 01/2010)
5. Kim, Tae-Kang: 3 articles (07/2015 - 12/2010)
6. Chen, Jianjun: 3 articles (05/2013 - 12/2010)
7. Miller, Duane: 3 articles (09/2012 - 01/2010)
8. But, W M: 2 articles (12/2015 - 12/2012)
9. Thompson, Ian M: 2 articles (11/2015 - 10/2011)
10. Wang, Jin: 2 articles (07/2015 - 09/2012)

Related Diseases

1. Prostatic Neoplasms (Prostate Cancer)
2. Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
3. Endometrial Neoplasms (Endometrial Cancer)
4. Breast Neoplasms (Breast Cancer)
5. Hyperplasia

Related Drugs and Biologics

1. Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)
2. Cytochrome P-450 Enzyme System (Cytochrome P450)
3. Cholesterol
4. steroidogenic acute regulatory protein
5. Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)
6. Estrogens (Estrogen)
7. Enzymes
8. Hydrocortisone (Cortisol)
9. Aromatase (CYP19)
10. Heme (Haem)

Related Therapies and Procedures

1. Chemoprevention
2. Prostatectomy (Retropubic Prostatectomy)