|3.||Liver Diseases (Liver Disease)
|1.||Williamson, Catherine: 13 articles (06/2015 - 08/2007)|
|2.||Beuers, Ulrich: 13 articles (04/2015 - 09/2002)|
|3.||Kobayashi, Keiko: 12 articles (11/2012 - 11/2002)|
|4.||Marschall, Hanns-Ulrich: 11 articles (02/2016 - 12/2005)|
|5.||Saheki, Takeyori: 11 articles (11/2012 - 11/2002)|
|6.||Oude Elferink, Ronald P J: 10 articles (04/2015 - 01/2008)|
|7.||Zhang, Li: 9 articles (03/2015 - 07/2003)|
|8.||Liu, Shu-yun: 8 articles (02/2008 - 05/2004)|
|9.||Chambers, Jenny: 7 articles (06/2015 - 08/2007)|
|10.||Knisely, A S: 7 articles (12/2014 - 12/2000)|
|1.||Ursodeoxycholic Acid (Urso)FDA LinkGeneric
09/27/1999 - "Ursodeoxycholic acid is an effective treatment of intrahepatic cholestasis of pregnancy, but the effect seems to decrease after a period."
01/01/1999 - "The improvements in the clinical and biochemical parameters and tolerability of the drug suggest that ursodeoxycholic acid is a safe and effective treatment in children with intrahepatic cholestasis."
12/01/2012 - "Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis."
01/01/2007 - "The hydrophilic bile acid ursodeoxycholic acid (10-20 mg/kg/d) is today regarded as the first line treatment for intrahepatic cholestasis of pregnancy. "
03/01/2006 - "To compare the efficacy of the monotherapy with ursodeoxycholic acid and S- adenosyl-L-methione with combined effect of both drugs in the treatment in pregnant women with intrahepatic cholestasis of pregnancy. "
|2.||Bile Acids and Salts (Bile Acids)IBA
10/01/1992 - "These results may indicate that UDCA is effective for the intrahepatic cholestasis in the case with no bile duct epithelial damage but in the presence of it hepato-cellular injury is introduced by the accumulated toxic bile acids in the blood."
12/01/2011 - "The aim of this study was to determine the incidence, obstetrical and fetal complication rates of intrahepatic cholestasis of pregnancy in patients managed actively around 38 weeks and evaluate the correlation of these results with liver function tests and bile acids. "
12/01/2007 - "This study demonstrated that HGF is a novel regulator of CYP7A1 and bile acid synthesis in human hepatocytes and may protect hepatocytes from accumulating toxic bile acids and developing intrahepatic cholestasis during the early stage of liver regeneration."
01/01/1991 - "To study a possible effect of the concentration of bile acids on the umbilical circulation we performed pulse-wave Doppler velocimetry of the umbilical artery in 15 patients with intrahepatic cholestasis between 34 and 38 weeks of gestation. "
01/01/2016 - "The increase in bile acids observed in patients with intrahepatic cholestasis of pregnancy has been noted to cause a change in the immune system from the normally mediated TH2 response to one that is more oriented towards TH1. "
|3.||Rifampin (Rifampicin)FDA LinkGeneric
06/01/2015 - "Rifampicin in the treatment of severe intrahepatic cholestasis of pregnancy."
01/01/2008 - "The second case had developed intrahepatic cholestasis in the presence of subclinical hyperthyroidism, and improved with rifampicin treatment. "
12/01/2008 - "Successfully treated intractable pruritus with rifampin in a case of benign recurrent intrahepatic cholestasis."
09/01/1998 - "Rifampicin is an effective drug against pruritus in intrahepatic cholestasis. "
08/01/1997 - "Benign recurrent intrahepatic cholestasis: improvement of pruritus and shortening of the symptomatic phase with rifampin therapy: a case report."
07/01/1990 - "In conclusion, short-term administration of oral S-adenosylmethionine is more effective than placebo in improving clinical and laboratory measures of intrahepatic cholestasis and offers a new therapeutic modality for the symptomatic management of this syndrome."
07/01/1990 - "Parenteral S-adenosylmethionine proved to be effective in reversing intrahepatic cholestasis in pregnant women. "
10/01/1993 - "[A meta-analysis of therapeutic trials with ademetionine in the treatment of intrahepatic cholestasis]."
01/01/1990 - "A review of the studies on the clinical use of S-adenosylmethionine (SAMe) for the symptomatic treatment of intrahepatic cholestasis."
04/01/2010 - "Therefore, ademetionine can be widely used for treatment of intrahepatic cholestasis in children."
|5.||Estrogens (Estrogen)FDA Link
10/01/2009 - "Physiologically, this repression conferred on female mice protection against estrogen-induced intrahepatic cholestasis, the most common hepatic disease during pregnancy, suggesting a therapeutic target for prevention of this disease."
11/01/2011 - "Physiologically, this control confers protection against estrogen-induced intrahepatic cholestasis."
10/01/1993 - "As regard human pathology the efficacy of ademethionine was demonstrated firstly in intrahepatic cholestasis of pregnancy or estrogen-induced and later on in hepatic diseases with different etiology. "
03/01/2007 - "In this study, we tested whether a condition with compromised canalicular bile secretion, i.e., the estrogen-induced intrahepatic cholestasis, displays defective hepatocyte AQP8 functional expression. "
04/01/2015 - "We have previously shown that estrogen 17β-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-α and farnesoid X receptor (FXR) and transrepression of BSEP by E2/ERα is an etiological contributing factor to intrahepatic cholestasis of pregnancy. "
11/01/1990 - "However six equivocal studies were observed in profoundly jaundiced patients with bilirubin levels above 400 mumol l-1 due to difficulties in differentiating extrahepatic obstruction from severe intrahepatic cholestasis. "
02/01/1967 - "Serum bilirubin studies in patients with intermittent intrahepatic cholestasis."
01/01/2013 - "The mean direct bilirubin values of infants with BA and intrahepatic cholestasis were 141.9 and 111.3 μmol/L, respectively, which were significantly higher than 67.2 μmol/L seen in infants with draining scans. "
01/01/2008 - "We encountered a Japanese woman patient with familial intrahepatic cholestasis type 1 (FIC1) deficiency manifesting BRIC, in whom a rapid and gross elevation of serum total bile acid (TBA) level preceded that of serum total bilirubin level. "
01/01/1992 - "The pathophysiological bilirubin pattern was similar in patients with intrahepatic cholestasis. "
|7.||Methionine (L-Methionine)FDA Link
06/01/1991 - "In this study, the administration of S-adenosyl-L-methionine during 20 days did not improve intrahepatic cholestasis of pregnancy."
06/01/1991 - "S-adenosyl-L-methionine in the treatment of patients with intrahepatic cholestasis of pregnancy: a randomized, double-blind, placebo-controlled study with negative results."
04/01/2004 - "To evaluate the therapeutic effect of Yinchenghao decoction (YCHD) and S-adenosy-L-methionine (SAM) in treating intrahepatic cholestasis of pregnancy (ICP) and improving prognosis of perinatal newborn babies. "
06/01/1991 - "S-Adenosyl-L-methionine has been reported to induce beneficial effects in intrahepatic cholestasis of pregnancy. "
01/01/1990 - "Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis."
|8.||Narcotic Antagonists (Opioid Antagonists)IBA
06/01/2007 - "Depending on the underlying disease state resulting in cholestasis, phenobarbital, ursodiol, bile sequestering agents, and opioid antagonists appear to be most effective for treating pruritus related to intrahepatic cholestasis. "
04/01/2010 - "Some treatments have proven efficacy in randomized clinical trials in patients with cholestatic disorders, such as anion exchange resins, rifampicin, opioid antagonists and ursodeoxycholic acid; the latter is especially useful in intrahepatic cholestasis of pregnancy."
|9.||guar gum (guaran)IBA
04/01/2000 - "Forty-eight patients with intrahepatic cholestasis of pregnancy were randomized double-blind to receive either guar gum or placebo until delivery. "
04/01/2000 - "Guar gum relieved the intensity of pruritus without any side effects and prevented the rise in serum bile acid concentration in this placebo-controlled and double-blind study of patients with intrahepatic cholestasis of pregnancy."
04/01/2000 - "Oral guar gum, a gel-forming dietary fiber relieves pruritus in intrahepatic cholestasis of pregnancy."
05/01/1998 - "We conclude that in intrahepatic cholestasis of pregnancy and pruritus, guar gum treatment is beneficial in relieving pruritus, even although indicators of cholestasis are only partially reduced."
05/01/1998 - "Our aim was to investigate whether intestinal binding of bile acids by guar gum, a dietary fibre, relieves cholestasis and pruritus in intrahepatic cholestasis of pregnancy. "
|10.||gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA
02/01/2010 - "The aim of the study was to elucidate the role and characteristics of ATP8B1 gene mutations in mainland Chinese children with progressive intrahepatic cholestasis and low gamma-glutamyltransferase (GGT). "
09/01/2009 - "Among 299 women with intrahepatic cholestasis of pregnancy, 10 showing raised gamma-glutamyl transpeptidase were enrolled in this study. "
12/01/2014 - "γ-Glutamyl transpeptidase level as a screening marker among diverse etiologies of infantile intrahepatic cholestasis."
08/01/2012 - "In mainland Chinese children, some cases of chronic intrahepatic cholestasis with high γ-glutamyl transpeptidase could be attributed to ABCB4 mutations. "
08/01/2012 - "Thirteen patients with chronic intrahepatic cholestasis and elevated serum γ-glutamyl transpeptidase activity of unknown cause were enrolled in a single pediatric center. "
|1.||Total Parenteral Nutrition
07/01/2000 - "There are few long-term chronological reviews examining the incidence of total parenteral nutrition (TPN)-associated intrahepatic cholestasis (TPNAC) in infants. "
07/01/2000 - "Total parenteral nutrition-associated intrahepatic cholestasis in infants: 25 years' experience."
02/01/1999 - "Total parenteral nutrition (TPN) causes intrahepatic cholestasis and membrane phospholipid changes. "
12/01/1990 - "A new method of total parenteral nutrition for surgical neonates: it is possible that cyclic TPN prevents intrahepatic cholestasis."
02/01/1987 - "Intrahepatic cholestasis is a frequent, however, unresolved complication of total parenteral nutrition in infancy. "
|2.||Drug Therapy (Chemotherapy)
08/01/2010 - "Mutation specific drug therapy for progressive familial or benign recurrent intrahepatic cholestasis: a new tool in a near future?"
10/01/1990 - "The patient with familial intrahepatic cholestasis received chemotherapy for secondary lymphoproliferative disease that had not responded to the cessation of immunosuppression. "
07/01/1997 - "We report a rare case of systemic mastocytosis causing intrahepatic cholestasis that resolved with remission of AML following chemotherapy."
09/01/2002 - "To review the drug therapy for the treatment of itching associated with intrahepatic cholestasis of pregnancy (ICP). "
01/01/1992 - "With the aging of the population and the common occurrence of poly-drug therapy in geriatric patients, it is to be expected that jaundice due to drug-induced intrahepatic cholestasis will become even more prevalent, and accordingly the need to understand the basic mechanisms of this disease condition will become more urgent. "
07/01/2011 - "The aim of this study is to evaluate the incidence, etiology, and risk facrors for prolonged severe intrahepatic cholestasis (PSIC) after 129 pediatric living-donor liver transplantations (LDLT). "
07/01/2011 - "Incidence and risk factors for the development of prolonged severe intrahepatic cholestasis after pediatric living-donor liver transplantation."
01/01/2011 - "Orthotopic liver transplantation in a pediatric patient with progressive intrahepatic cholestasis: a coordinated perioperative subspecialty approach."
08/01/2008 - "[The mechanisms and treatment of intrahepatic cholestasis after liver transplantation]."
02/01/2008 - "Intrahepatic cholestasis after liver transplantation."
06/01/1995 - "To investigate the cause of intrahepatic cholestasis, which is frequently associated with sepsis, we studied the effects of cecal ligation and puncture (CLP) and surgical stress on bile acid secretion and composition. "
10/01/1984 - "In our studies, transport of 99mTc-PIPIDA by isolated rat hepatocytes obtained from animals with extrahepatic obstruction secondary to bile duct ligation or intrahepatic cholestasis induced by ethinyl estradiol therapy was determined. "
08/01/1999 - "Sprague-Dawley rats with extrahepatic and intrahepatic cholestasis were prepared by bile duct ligation (6 hr or three days) and phalloidin infusion (0.4 mg/kg body weight), respectively. "
01/01/1999 - "We used rat models of intrahepatic cholestasis by ethinyl estradiol (EE) treatment and extrahepatic cholestasis by bile duct ligation (BDL) to precisely determine the site of TJ damage. "
07/01/1988 - "Thus, plasma alkaline phosphodiesterase I does not offer as sensitive a marker of intrahepatic cholestasis (induced by ANIT) as it does of extrahepatic cholestasis (induced by bile duct ligation). "
06/01/2005 - "Plasmapheresis for the treatment of intrahepatic cholestasis of pregnancy refractory to medical treatment."
01/01/1988 - "Plasmapheresis: an effective therapy for cholestatic episodes related to benign recurrent intrahepatic cholestasis?"
08/01/1984 - "[Treatment of intractable intrahepatic cholestasis with plasmapheresis]."
10/01/1989 - "The purpose of our study of 26 patients was to emphasize some features uncommonly or never reported in this disease: (a) in each patient, the attacks of cholestasis were stereotypic; (b) attacks of cholestasis were not associated with pruritus in 15% of our patients; (c) the occurrence of attacks of cholestasis during pregnancy or oral contraceptive use might be a fortuitous coincidence; (d) gallstones were found in several patients with benign recurrent intrahepatic cholestasis and might be present earlier than in the general population; (e) in some of our patients, during attacks of cholestasis, serum transaminases were very high, exceeding 15 times the upper limit of normal; (f) mild portal inflammatory infiltration was found in one third of our patients; (g) no treatment shortened the duration of cholestasis, and in a few patients, plasmapheresis seemed to diminish jaundice and improve biochemical disorders."