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Chlorprothixene (Taractan)

A thioxanthine with effects similar to the phenothiazine antipsychotics.

Also Known As:

Taractan; Chlorprotixen; 1-Propanamine, 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-, (Z)-

Networked: 69 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thioxanthenes: 11
    - Chlorprothixene: 69
      - chlorprothixene sulfoxide: 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - Thioxanthenes: 11
        Chlorprothixene: 69
        chlorprothixene sulfoxide: 1

Experts

1.	Andersen, Kjeld: 1 article (04/2022)
2.	Fink-Jensen, Anders: 1 article (04/2022)
3.	Hallas, Jesper: 1 article (04/2022)
4.	Højlund, Mikkel: 1 article (04/2022)
5.	Wagner, Christina Blanner: 1 article (04/2022)
6.	Wesselhoeft, Rikke: 1 article (04/2022)
7.	Du, Yuxin: 1 article (01/2020)
8.	Junaid, Muhammad: 1 article (01/2020)
9.	Kaushik, Aman Chandra: 1 article (01/2020)
10.	Li, Kening: 1 article (01/2020)

Related Diseases

1.	Glioma (Gliomas) 11/01/1998 - "The phenothiazines (chlorpromazine, chlorprothixene, and triflupromazine) inhibited Acanthamoeba growth by 70-90% at 5 and 10 micrograms/ml, but some of these compounds were toxic for rat glioma cells at 10 micrograms/ml. Azithromycin was not very effective against B. "
2.	Schizophrenia (Dementia Praecox) 05/01/1963 - "A controlled trial of taractan in chronic schizophrenia." 01/01/1991 - "A controlled comparative study of chlorprothixene vs. haloperidol in chronic schizophrenia." 12/01/1971 - "A comparison of chlorprothixene and haloperidol in acute schizophrenia." 01/16/2015 - "We included all randomised controlled trials (RCTs) that compared oral haloperidol with another oral first-generation antipsychotic drug (with the exception of the low-potency antipsychotics chlorpromazine, chlorprothixene, levopromazine, mesoridazine, perazine, prochlorpromazine, and thioridazine) in schizophrenia and schizophrenia-like psychosis. "
3.	Psychotic Disorders (Schizoaffective Disorder) 07/01/2009 - "Chlorprothixene (CPTX, Taractan) is a low potency antipsychotic mainly used for the treatment of psychotic disorders (e.g. " 10/01/1961 - "Clinical observations of therapeutic effect of chlorprothixene (Taractan) in psychoses." 01/16/2015 - "We included all randomised controlled trials (RCTs) that compared oral haloperidol with another oral first-generation antipsychotic drug (with the exception of the low-potency antipsychotics chlorpromazine, chlorprothixene, levopromazine, mesoridazine, perazine, prochlorpromazine, and thioridazine) in schizophrenia and schizophrenia-like psychosis. " 03/01/2009 - "The manifestations of poisoning in the 17 documented cases included malaise, tachycardia, headache, agitation, arterial hypertension, nausea, vomiting, dyspnea, insomnia, left-sided chest pressure, elevated temperature, and, in two cases, psychosis after the substance was combined with atomoxetine and methylphenidate and with citalopram, olanzapine, and chlorprothixene. "
4.	Depressive Disorder (Melancholia) 01/01/1961 - "The combined treatment of endogenous depression with imipramine (tofranil) and chlorprothixene (truxal), with special reference to ambulant therapy." 12/01/1982 - "[Comparison of the therapeutic effect of bromazepam and chlorprothixene in depressive neuroses]." 03/01/1988 - "Antidepressant combination therapy of endogenous depressions with benzodiazepines or neuroleptics--a study comparing adjuvant treatment with oxazolam versus chlorprothixene."
5.	Neuralgia (Stump Neuralgia) 12/01/1978 - "Two trials of chlorprothixene were carried out, mainly on patients with moderate to severe post-herpetic neuralgia. " 07/01/1974 - "Chlorprothixene therapy for herpes zoster neuralgia." 12/01/1978 - "Chlorprothixene (taractan) in post-herpetic neuralgia and other severe chronic pains."

Related Drugs and Biologics

1.	Chlorpromazine (Thorazine)
2.	Triflupromazine
3.	Azithromycin (Zithromax)
4.	Phenothiazines
5.	Dihydrotachysterol (AT 10)
6.	Antipsychotic Agents (Antipsychotics)
7.	Haloperidol (Haldol)
8.	Methotrimeprazine (Levomepromazine)
9.	Antidepressive Agents (Antidepressants)
10.	Perazine

Related Therapies and Procedures

1.	Therapeutics
2.	Anesthesia