Chloroguanide (Proguanil)

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282 relevant articles (39 outcomes, 34 trials/studies) found for this Drug

Description: A biguanide compound which has little antimalarial activity until metabolized in the body to the active antimalarial agent cycloguanil. The usefulness of proguanil is limited by the rapid development of drug resistance by the malarial parasite. The hydrochloride is used for the casual prophylaxis of falciparum malaria, to suppress other forms of malaria, and to reduce transmission of infection (From Martindale, The Extra Pharmacopoeia, 30th ed, p405)

Also Known As:

Proguanil; Paludrine; Astra Brand of Chloroguanide Hydrochloride; AstraZeneca Brand of Chloroguanide Hydrochloride; Bigumal; Chloriguane; Chloroguanide Hydrochloride; Paludrin; Proguanil Hydrochloride; Zeneca Brand of Chloroguanide Hydrochloride; Hydrochloride, Chloroguanide; Hydrochloride, Proguanil; Chlorguanid; Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-

Relationship Network

Drug Context: Research Results

Organic Chemicals: 42

atovaquone-proguanil: 94

malarone: 49

cycloguanil: 42

chlorproguanil-dapsone: 34

chlorproguanil: 22

PS 15: 11

LAPDAP combination: 2

Preparation ABP: 1

Experts

1.	Kain, Kevin C: 7 articles (06/2008 - 01/2003)
2.	Looareesuwan, Sornchai: 4 articles (04/2007 - 12/2002)
3.	Miller, Gerri B: 4 articles (06/2004 - 10/2002)
4.	Maguire, Jason D: 3 articles (11/2007 - 10/2002)
5.	White, Nicholas J: 3 articles (09/2005 - 12/2002)
6.	Overbosch, D: 3 articles (09/2002 - 12/2000)
7.	Le Bras, M: 3 articles (01/2002 - 11/2000)
8.	Chulay, J D: 3 articles (10/2001 - 11/2000)
9.	Ogutu, Bernhards: 2 articles (07/2008 - 04/2008)
10.	Polhemus, Mark E: 2 articles (07/2008 - 04/2008)

Related Diseases

1.	Malaria 01/01/1988 - "This regimen was the most effective in preventing malaria attacks in the previous 12 months, even though over half those on proguanil alone were taking an inadequate dose. " 05/01/1997 - "None of the 11 patients treated with proguanil were cured of malaria and their phenotype status did not affect the treatment outcome. " 01/01/1992 - "The study shows the importance of malaria in an endemic area among expatriates despite the observance of chemoprophylactics regimens including proguanil." 10/28/2006 - "She had taken paludrine as a prophylactic against malaria. " 01/01/2006 - "METHODS: We performed a systematic review of the medical bibliographic databases PubMed, Excerpta Medica, LILACS, and SciELO by using the following Spanish and English descriptors: "CYP-450" and "citocromo P-450" in combination with "proguanil" (and with "mefloquina," "cloroquina," and "amodiaquina"), "farmacocinética de proguanil" (and the same using "mefloquina," "cloroquina," and "amodiaquina"), "resistencia a proguanil" (and the same using "mefloquina," "cloroquina," and "amodiaquina"), "metabolismo," "farmacogenética," "enfermedad," "inflamación," "infección," "enfermedad hepática," "malaria," "nutrición," and "desnutrición." The same terms were used in English. " Order ALL the reference details at left...
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 05/01/2002 - "Polyclonal Plasmodium falciparum malaria in travelers and selection of antifolate mutations after proguanil prophylaxis." 12/01/1997 - "The antifolate proguanil is commonly used in the prophylaxis and treatment of Plasmodium falciparum malaria. " 05/01/1997 - "Disposition of proguanil in Thai patients with uncomplicated falciparum malaria." 03/01/1988 - "The data were suggestive that proguanil may have some causal prophylactic effect against falciparum malaria. " 03/01/1988 - "Among 85 children taking proguanil for 524 human-weeks, there were 17 cases of falciparum malaria and 11 cases of vivax. " Order ALL the reference details at left...
3.	Infection 04/01/1999 - "To study this, 95 subjects with uncomplicated Plasmodium falciparum or Plasmodium vivax infections in Vanuatu received proguanil treatment for 3 days (adult relative dose of 300-500 mg/day) and were followed up for 28 days. " 06/01/1999 - "vivax infections, received proguanil treatment for 3 days in daily doses corresponding to adult doses of 300-500 mg. Capillary blood samples were collected on filter paper for determining both human CYP2C19 mutations by polymerase chain reaction and mutation-specific restriction enzyme digestion and blood concentrations of proguanil and its metabolites by high-performance liquid chromatography. " 08/06/1988 - "One new infection was found during 3893 days of follow up in the mosquito net group, eight new infections over 3667 days in the proguanil group, and 35 new infections over 3677 days in the placebo group, representing a reduction of 97.3% and 77.1% in attack rates for the mosquito net method and for treatment with proguanil respectively. " 06/18/1949 - "Proguanil prophylaxis and inter-current infection." 03/01/1949 - "Development of resistance to chlorguanide (paludrine) during treatment of infections with Plasmodium cynomolgi." Order ALL the reference details at left...
4.	Vivax Malaria 03/01/1949 - "The suppressive action of paludrine in benign tertian (vivax) malaria." 05/01/1948 - "The therapeutic effectiveness of large doses of paludrine in acute attacks of sporozoite-induced vivax malaria, Chesson strain." 01/01/1986 - "In this geographical location, where malaria transmission is now light, a combination of strict personal antimosquito measures plus proguanil 200 mg daily produced effective, safe protection, with only a single case of vivax malaria occurring. " 04/01/1999 - "The results suggest that the parent compound proguanil has significant intrinsic efficacy against falciparum and vivax malaria independent of the metabolite cycloguanil." 04/01/1999 - "Intrinsic efficacy of proguanil against falciparum and vivax malaria independent of the metabolite cycloguanil." Order ALL the reference details at left...
5.	Theileriasis 04/01/1967 - "[The efficacy of quinocide and bigumal in theileriasis]" Order ALL the reference details at left...

Related Drugs and Biologics

1.	Chloroquine (Aralen)
2.	Atovaquone (Mepron)
3.	Mefloquine (Lariam)
4.	Dapsone
5.	cycloguanil
6.	sulfadoxine-pyrimethamine (Fansidar)
7.	Chloroguanide (Proguanil)
8.	Pyrimethamine (Daraprim)
9.	Antimalarials (Antimalarial Agents)
10.	malarone

Related Therapies and Procedures

1.	Chemoprevention
2.	Protective Clothing
3.	Drug Therapy (Chemotherapy)
4.	Directly Observed Therapy
5.	Renal Dialysis (Hemodialysis)

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