Chlormethiazole (Clomethiazole)

A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent. The mechanism of its therapeutic activity is not entirely clear, but it does potentiate GAMMA-AMINOBUTYRIC ACID receptors response and it may also affect glycine receptors.

Also Known As:

Networked: 254 relevant articles (17 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liu, Jia: 4 articles (10/2018 - 02/2013)
2.	Wang, Lu-Ning: 4 articles (10/2018 - 02/2013)
3.	Ashwood, T: 4 articles (01/2002 - 01/2000)
4.	Lyden, P: 4 articles (01/2002 - 11/2000)
5.	Green, A R: 4 articles (08/2001 - 04/2000)
6.	Wahlgren, N G: 4 articles (11/2000 - 01/2000)
7.	Seitz, Helmut K: 3 articles (01/2022 - 11/2002)
8.	Lyden, Patrick: 3 articles (03/2007 - 08/2003)
9.	Jackson, D M: 3 articles (01/2007 - 05/2000)
10.	Ashwood, Tim: 3 articles (11/2004 - 08/2003)

Related Diseases

1.	Stroke (Strokes) 11/01/2000 - "However, a post hoc analysis based on a prospective clinical classification showed that clomethiazole was effective in a subgroup of patients who had deficits of a major stroke. " 01/01/1999 - "The hypothesis that clomethiazole is effective in patients with large strokes will be tested in a further study." 03/01/2007 - "Secondary analysis of data from the Clomethiazole for Acute Stroke Study-Ischemic using the Rasch partial credit model. " 03/01/2007 - "Measurement properties of the National Institutes of Health Stroke Scale for people with right- and left-hemisphere lesions: further analysis of the clomethiazole for acute stroke study-ischemic (class-I) trial." 11/01/2004 - "The Clomethiazole for Acute Stroke Study-Ischemic, conducted in academic and community hospitals. "
2.	Alcohol Withdrawal Delirium (Delirium Tremens) 09/10/1990 - "Clomethiazol (Distraneurin) has decisively improved our therapeutic possibilities in delirium tremens. " 01/01/1986 - "The efficacy of early chlormethiazole medication in the prevention of delirium tremens. " 08/01/2005 - "The REM sleep-suppressing component of clomethiazole is of great interest in connection with its use in treating delirium tremens. " 03/18/1989 - "Chlormethiazole and treatment of delirium tremens." 01/01/1986 - "To assess the contribution of chlormethiazole to the treatment of delirium tremens (DT), a retrospective analysis was carried out on cases of DT admitted to the Department of Psychiatry, University of Tübingen, West Germany before and after the introduction of chlormethiazole. "
3.	Ischemic Stroke 01/01/2002 - "Clomethiazole does not improve outcome in patients with major ischemic stroke." 01/01/2002 - "A total of 1198 patients with major ischemic stroke and a combination of limb weakness, higher cortical dysfunction, and visual field deficits were randomly assigned to clomethiazole (68 mg/kg IV over 24 hours) or placebo. " 11/01/2000 - "A further clinical trial of clomethiazole in patients with deficits consistent with a major ischemic stroke is currently underway (CLASS-I). " 11/01/2000 - "Clomethiazole ('ZENDRA'; a trademark, the property of the AstraZeneca group of companies) is also undergoing a second large clinical trial in patients with major ischemic strokes. " 06/30/2000 - "Clomethiazole is neuroprotective in a variety of animal models of ischaemic stroke, but the mechanism is unclear. "
4.	Ischemia 11/01/1998 - "This review discusses the efficacy of clomethiazole (CMZ) in models of global and focal ischemia. " 03/21/1997 - "The functional and neuroanatomical protective effects of clomethiazole (CMZ) were examined in an animal model of global forebrain ischemia. " 02/01/1999 - "A large-scale phase III trial has been completed in which clomethiazole was evaluated for its ability to reduce nerve damage in acute cerebrovascular ischemia. " 08/01/2003 - "Gerbils were exposed to 5 min of global ischemia and received 400 mg/ml clomethiazole (via osmotic minipump) plus a bolus injection (60 mg/kg) 30 min after ischemia. " 08/01/2003 - "Long-term effects of clomethiazole in a model of global ischemia."
5.	Seizures (Absence Seizure) 04/27/1991 - "[Effectiveness of chlormethiazole at 0.8 percent in epileptic seizures]." 02/01/1981 - "There was a direct relationship between dose of chlormethiazole and frequency of apnoeic-tonic seizures. " 01/01/1986 - "Chlormethiazole in the management of post-craniotomy seizures." 07/01/2016 - "Using Clomethiazole or Oxazepam in a daily reduced dose and with daily personal contacts, the ambulant withdrawal in patients without seizures or delir in medical history is a secure and successful therapeutic option. " 01/01/2011 - "Because of a need for extra precautions against complications such as seizures and severe respiratory complaints, patients with a history of withdrawal seizures or complications with clomethiazole in their history were automatically assigned to the clonazepam group. "

Related Drugs and Biologics

1.	gamma-Aminobutyric Acid (GABA)
2.	Benzodiazepines
3.	Hypnotics and Sedatives (Sedatives)
4.	Carbamazepine (Tegretol)
5.	Ethanol (Ethyl Alcohol)
6.	Cytochrome P-450 CYP2E1 (CYP2E1)
7.	Clonidine (ST 155)
8.	N-Methylaspartate (NMDA)
9.	Thioridazine (Mellaril)
10.	Kainic Acid (Kainate)

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Therapeutics
3.	Ligation
4.	Intravenous Administration
5.	Urinary Catheters