|1.||Lyden, P: 4 articles (01/2002 - 11/2000)|
|2.||Ashwood, T: 4 articles (01/2002 - 01/2000)|
|3.||Green, A R: 4 articles (08/2001 - 04/2000)|
|4.||Wahlgren, N G: 4 articles (11/2000 - 01/2000)|
|5.||Lyden, Patrick: 3 articles (03/2007 - 08/2003)|
|6.||Jackson, D M: 3 articles (01/2007 - 05/2000)|
|7.||Ashwood, Tim: 3 articles (11/2004 - 08/2003)|
|8.||Odergren, Tomas: 3 articles (01/2004 - 06/2003)|
|9.||Cross, A J: 3 articles (08/2001 - 04/2000)|
|10.||Liu, Jia: 2 articles (01/2014 - 01/2013)|
01/01/2002 - "A previous trial (the Clomethiazole Acute Stroke Study) generated the hypothesis that clomethiazole is effective in patients with a major ischemic stroke (total anterior circulation syndrome), and this was tested in the present study. "
11/01/2000 - "However, a post hoc analysis based on a prospective clinical classification showed that clomethiazole was effective in a subgroup of patients who had deficits of a major stroke. "
01/01/1999 - "The hypothesis that clomethiazole is effective in patients with large strokes will be tested in a further study."
01/01/2014 - "Chlormethiazole (CMZ), a clinical sedative/anxiolytic agent, did not reach clinical efficacy in stroke trials despite neuroprotection demonstrated in numerous animal models. "
03/01/2007 - "Secondary analysis of data from the Clomethiazole for Acute Stroke Study-Ischemic using the Rasch partial credit model. "
01/01/1993 - "Chlormethiazole (155-622 mumol/kg IP) given 15 min before NMDLA (3400 mumol/kg) dose-dependently inhibited all the behaviours, increasing the latency to appearance of scratching, running and clonus and reducing the incidence of pawing, loss of righting and tonic convulsions. "
01/01/1990 - "The time course of the effect of chlormethiazole (100 mg/kg) in the withdrawal test was similar to its effect in raising seizure threshold and decreasing locomotor activity. "
12/01/1983 - "Chlormethiazole should be considered in the treatment of resistant convulsions in the newborn."
02/01/1981 - "There was a direct relationship between dose of chlormethiazole and frequency of apnoeic-tonic seizures. "
01/01/1986 - "Chlormethiazole in the management of post-craniotomy seizures."
|3.||Alcohol Withdrawal Delirium (Delirium Tremens)
09/10/1990 - "Clomethiazol (Distraneurin) has decisively improved our therapeutic possibilities in delirium tremens. "
01/01/1986 - "The efficacy of early chlormethiazole medication in the prevention of delirium tremens. "
08/01/2005 - "The REM sleep-suppressing component of clomethiazole is of great interest in connection with its use in treating delirium tremens. "
01/01/1992 - "[Treatment of delirium tremens--a comparison between clomethiazole and clorazepate with reference to effectiveness and rate of side effects]."
03/18/1989 - "Chlormethiazole and treatment of delirium tremens."
11/01/1998 - "This review discusses the efficacy of clomethiazole (CMZ) in models of global and focal ischemia. "
03/21/1997 - "The functional and neuroanatomical protective effects of clomethiazole (CMZ) were examined in an animal model of global forebrain ischemia. "
02/01/1999 - "A large-scale phase III trial has been completed in which clomethiazole was evaluated for its ability to reduce nerve damage in acute cerebrovascular ischemia. "
08/01/2003 - "Gerbils were exposed to 5 min of global ischemia and received 400 mg/ml clomethiazole (via osmotic minipump) plus a bolus injection (60 mg/kg) 30 min after ischemia. "
08/01/2003 - "Long-term effects of clomethiazole in a model of global ischemia."
|5.||Brain Ischemia (Cerebral Ischemia)
11/01/1998 - "Clomethiazole is a drug with sedative properties effective in laboratory studies of brain ischemia. "
09/01/2002 - "The neuroprotective property of clomethiazole has been demonstrated in several animal models of global and focal brain ischemia. "
04/17/2000 - "We investigated the neuroprotective effect of infusing various doses of clomethiazole in models of global and focal cerebral ischemia. "
04/17/2000 - "Clomethiazole is neuroprotective in models of global and focal cerebral ischemia when infused at doses producing clinically relevant plasma concentrations."
03/01/1999 - "Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species."
|1.||gamma-Aminobutyric Acid (GABA)
|3.||Clonidine (ST 155)
|7.||Kainic Acid (Kainate)
|9.||Ethanol (Ethyl Alcohol)
|10.||Cytochrome P-450 CYP2E1 (CYP2E1)
|4.||Artificial Respiration (Mechanical Ventilation)