Chloral Hydrate

08/01/1996 - "Chloral hydrate is a safe and effective agent for sedation of children with known or suspected congenital heart disease who are undergoing echocardiography in the outpatient cardiology clinic."
08/01/1996 - "The purpose of this prospective study was to determine the safety and efficacy of chloral hydrate sedation in children with known or suspected congenital heart disease. "
01/01/2017 - "This study evaluates the safety and efficacy of chloral hydrate administration for the conscious sedation of infants in the pediatric cardiovascular intensive care unit (PCICU).We conducted a retrospective review of the charts of 165 infants with congenital heart disease who received chloral hydrate in our PCICU between January 2014 and December 2014. "

03/19/2007 - "Focal ischemia was induced under chloral hydrate anaesthesia by unilateral permanent MCAo. "
08/01/2002 - "Carboxyfullerene was either intravenously (6 mg/kg) or intracerebroventricularly (0.1, 0.3 mg per rat) infused to the chloral hydrate-anesthetized Sprague-Dawley rats 30 min prior to transient ischemia-reperfusion. "
01/12/1998 - "CD-1 mice anesthetized by chloral hydrate were subjected to global ischemia by bilateral common carotid artery occlusion under controlled ventilation for 3, 5, and 10 min. After evaluating the patency of the posterior communicating artery (PcomA) as hypoplastic or normoplastic, neuronal injury was independently determined in the striatum, cortex, and hippocampus in each hemisphere. "
12/01/2003 - "Ischemia was induced in male Swiss mice, anaesthetized with chloral hydrate (400 mg/kg, i.p.), by a 15-min-occlusion of the left middle cerebral artery using an intraluminal suture. "
01/01/2023 - "Our study provides a molecular basis for understanding the proton-dependent activation mechanism of the hPAC channel and a novel drug target of chloral hydrate.SIGNIFICANCE STATEMENT Proton-activated Cl- channel (PAC) channels are widely distributed in the nervous system and play a vital pathophysiological role in ischemia and endosomal acidification. "

01/01/2021 - "The current results do not support sleep deprivation have a beneficial effect in reducing the pediatric chloral hydrate sedation failure rate. "
01/01/2021 - "Of the 7789 patients undergoing chloral hydrate sedation, 6352 were treated with sleep deprivation and 1437 with non-sleep deprivation. "
01/01/2021 - "Sleep deprivation did not enhance the success rate of chloral hydrate sedation for non-invasive procedural sedation in pediatric patients."
10/01/1997 - "Chloral hydrate and sleep deprivation for sedation during flexible fiberoptic bronchoscopy."
05/01/1993 - "Use of sedation procedures that include oral chloral hydrate after sleep deprivation resulted in a failure rate of 3.8% in sedating outpatient children. "

05/01/2002 - "Nowadays should we be using chloral hydrate in cases of insomnia in adult and older people? "
01/01/1992 - "During their captivity the doctor prescribed them 4 g chloral hydrate per day because of insomnia. "
10/01/1991 - "A 42-year-old woman had an accidental overdose of chloral hydrate due to repeated absorption of a therapeutic dose of chloral syrup for insomnia. "
01/01/1980 - "Neither chloral hydrate not L-tryptophan had any significant side effects, but withdrawal of chloral hydrate was associated with insomnia."
08/01/1961 - "A new tablet form of chloral hydrate (WM-1127) in the treatment of insomnia in the aged: double-blind study."

09/01/1990 - "The study suggest that chloral hydrate is a safe and effective oral sedative but that children with neurologic disorders may need alternative drugs for sedation."