Chitin Synthase

An enzyme that converts UDP glucosamine into chitin and UDP. EC 2.4.1.16.

Also Known As:

Chitin Synthase 1; Chitin Synthetase 2; trans-N-Acetylglucosaminosylase; Acetylglucosaminyltransferase, Chitin-UDP; Chitin UDP Acetylglucosaminyltransferase; trans N Acetylglucosaminosylase; Chitin-UDP Acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyltransferase

Networked: 39 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zhang, Xin: 2 articles (04/2013 - 09/2012)
2.	Liu, Hongbo: 2 articles (11/2007 - 02/2004)
3.	Szaniszlo, Paul J: 2 articles (11/2007 - 02/2004)
4.	Hasegawa, A: 2 articles (08/2001 - 01/2000)
5.	Kano, R: 2 articles (08/2001 - 01/2000)
6.	Nakamura, Y: 2 articles (08/2001 - 01/2000)
7.	Watanabe, S: 2 articles (08/2001 - 01/2000)
8.	Abbondante, Serena: 1 article (01/2019)
9.	Armstrong, Brittany: 1 article (01/2019)
10.	Beauvais, Anne: 1 article (01/2019)

Related Diseases

1.	Infections 01/01/2000 - "In the present study, to confirm Microsporum canis infection rapidly, we detected the chitin synthase gene 1 (CHS1) gene of M. " 02/01/2012 - "Different chitin synthase genes are required for various developmental and plant infection processes in the rice blast fungus Magnaporthe oryzae." 07/01/2010 - "Chitin synthase-deficient mutant of Fusarium oxysporum elicits tomato plant defence response and protects against wild-type infection." 11/01/2007 - "WdChs5p in Wangiella dermatitidis is a class V chitin synthase that is required for sustained cell growth at the temperature of infection (37 degrees C) and its encoding gene, WdCHS5, has a differential expression feature. " 02/01/2004 - "Wangiella (Exophiala) dermatitidis WdChs5p, a class V chitin synthase, is essential for sustained cell growth at temperature of infection."
2.	Aspergillosis 09/15/1996 - "A chsD- mutant strain constructed by gene disruption has a 20% reduction in total mycelial chitin content; however, no differences between the wild-type strain and the chsD- strain were found with respect to morphology, chitin synthase activity or virulence in a neutropenic murine model of aspergillosis. " 01/01/2023 - "The present study aimed at compositional profiling of PEO and molecular docking of PEO bioactive compound geraniol against fungal enzymes chitin synthase (CS), UDP-glycosyltransferase (UDPG) and glucosamine-6-phosphate synthase (GPS), as apposite sites for drug designing against "Aspergillosis" and "Mucormycosis" and in vitro confirmation. "
3.	Onychomycosis (Tinea Unguium) 10/01/2007 - "In this study, nested PCR using novel primers targeting the pan-dermatophyte-specific sequence of the chitin synthase 1 gene (CHS1) was compared with KOH microscopy, culture isolation, and single-round PCR for diagnosis of 152 patients with clinically suspected onychomycosis. "
4.	Mucormycosis 01/01/2023 - "The present study aimed at compositional profiling of PEO and molecular docking of PEO bioactive compound geraniol against fungal enzymes chitin synthase (CS), UDP-glycosyltransferase (UDPG) and glucosamine-6-phosphate synthase (GPS), as apposite sites for drug designing against "Aspergillosis" and "Mucormycosis" and in vitro confirmation. "
5.	Cysts 07/09/2023 - "Down-regulation of EiHbox1 by gene silencing reduced Chitin synthase, Jacob, and increased Jessie gene expression, resulting in defective cysts and decreased encystation efficiency and viability. " 08/01/2001 - "Previous research has shown that cyst-like structures formed in the presence of chitin synthase cofactors (Mg2+, Mn2+, and Co2+) resist 1% sodium dodecyl sulfate lysis (RCLS), whereas those formed in the absence of cofactors (CLS) do not, and trophozoites are immediately destroyed. " 08/01/2011 - "Entamoeba histolytica forms chitin-walled cysts during encystation process, where formation of the cyst wall needs not only chitin synthase but also chitinase. " 04/30/2005 - "Genes with very low expression ( approximately 16% of total) and those not expressed ( approximately 52% of total) included encystation-specific genes such as Jacob cyst wall glycoprotein (33.m00261), chitin synthase (3.m00544), and chitinase (22.m00311). "

Related Drugs and Biologics

1.	Glycosyltransferases
2.	Uridine Diphosphate Glucose (UDP Glucose)
3.	Uridine Diphosphate (UDP)
4.	Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
5.	Enzymes
6.	geraniol (nerol)
7.	Chitin
8.	nikkomycin
9.	Double-Stranded RNA (RNA, Double Stranded)
10.	Iron