Chilblains

Subscribe to Selected New Research on Chilblains

42 relevant articles (3 outcomes, 3 trials/studies) found for this Disease

Description: Recurrent localized itching, swelling and painful erythema on the fingers, toes or ears, produced by exposure to cold. It is also called pernio.

Also Known As:

Chilblain

Relationship Network

Disease Context: Research Results

Disorders of Environmental Origin

Wounds and Injuries: 60616

Frostbite: 250

Chilblains: 42

Related Diseases

1.	Purpura
2.	Syndrome
3.	Raynaud Disease (Raynaud's Disease)
4.	Vasculitis (Vasculitides)
5.	Thrombocytopenia (Thrombopenia)
31 Diseases and 17 more articles analyzed in the Research Interface, order at left...

Experts

1.	Perrino, Fred W: 1 article (05/2007)
2.	Engel, Kerstin: 1 article (05/2007)
3.	Gahr, Manfred: 1 article (05/2007)
4.	Pfeiffer, Christiane: 1 article (05/2007)
5.	Gong, Maoliang: 1 article (05/2007)
6.	Senenko, Lydia: 1 article (05/2007)
7.	Chowdhury, Dipanjan: 1 article (05/2007)
8.	Hubner, Norbert: 1 article (05/2007)
9.	Harvey, Scott: 1 article (05/2007)
10.	Hollis, Thomas: 1 article (05/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chilblains:

1.	Nifedipine (Adalat)FDA LinkGeneric 02/01/1989 - "At a dose of 20 mg to 60 mg daily, nifedipine significantly reduced the time to clearance of existing lesions and prevented the development of new chilblains" 02/01/1989 - "The treatment of chilblains with nifedipine: the results of a pilot study, a double-blind placebo-controlled randomized study and a long-term open trial." 05/01/2003 - "CONCLUSIONS: We conclude that nifedipine remains the drug of choice in chilblains but can be used in a smaller dosage in the Indian population" 10/11/1986 - "Nifedipine in the treatment of chilblains." 05/01/2003 - "AIMS: To compare the efficacy of diltiazem with that of nifedipine, and to determine the efficacy of nifedipine in lower doses, 36 chilblains cases were studied" Get all the results and reference details, order at left...
2.	Diltiazem (Cardizem)FDA LinkGeneric 05/01/2003 - "AIMS: To compare the efficacy of diltiazem with that of nifedipine, and to determine the efficacy of nifedipine in lower doses, 36 chilblains cases were studied" 05/01/2003 - "Diltiazem vs. nifedipine in chilblains: a clinical trial." Get all the results and reference details, order at left...
3.	AutoantibodiesIBA 01/01/1999 - "In conclusion, the present study suggests that chilblain LE is associated with SSA/Ro autoantibodies, as is SCLE, hypergammaglobulinemic purpura and neonatal lupus erythematosus." Get all the results and reference details, order at left...
4.	exodeoxyribonuclease IIBA 05/01/2007 - "In this study, we report the identification of a heterozygous missense mutation (D18N) in TREX1 encoding the 3'-5'repair exonuclease 1 in affected individuals of the family with chilblain lupus" Get all the results and reference details, order at left...
5.	Antinuclear AntibodiesIBA 05/01/2007 - "Familial chilblain lupus manifests in early childhood with ulcerating acral skin lesions and is associated with arthralgias and circulating antinuclear antibodies" 05/01/1978 - "The chilblain lesions are the result of microvascular injury secondary to exposure to cold and possibly hyperviscosity from immunological abnormalities, Elevated serum gammaglobulins, positive latex factor and speckled pattern antinuclear factor are common" 11/01/2000 - "At the age of 7 years, the patient developed a chilblain-like eruption with features of SLE, including leucopenia, oral ulcers, positive rheumatoid and antinuclear antibodies and positive anti-dsDNA, anti-Ro/SSA and anti-La/SSB antibodies" 12/01/2006 - "Antinuclear factor (ANF) was present in 22 patients, hypocomplementemia in 6, and antineutrophil cytoplasmic antibody in 5. Histology (30 biopsies from 27 patients) showed nonnecrotizing vasculitis in 12 patients, necrotizing vasculitis in 7, an inflammatory dermal infiltrate without vasculitis in 3, extravascular necrotic granulomas in 2, chilblain lupus in 1, and cicatricial fibro-inflammatory changes in 1. Renal biopsy in three patients showed extracapillary glomerulonephritis with IgA deposits (n=2) or active floccular necrosis against a background of glomerular sclerosis (n=1)" Get all the results and reference details, order at left...
6.	AntibodiesIBA 01/01/1999 - "Chilblain lupus erythematosus is associated with antibodies to SSA/Ro." 01/01/1999 - "Chilblain lupus erythematosus is associated with antibodies to SSA/Ro." 11/01/2000 - "At the age of 7 years, the patient developed a chilblain-like eruption with features of SLE, including leucopenia, oral ulcers, positive rheumatoid and antinuclear antibodies and positive anti-dsDNA, anti-Ro/SSA and anti-La/SSB antibodies" 05/01/2008 - "Only three patients developed clinical manifestations (chilblain lupus) possibly related to these auto-antibodies, two with infliximab and one with etanercept" Get all the results and reference details, order at left...
7.	Granzymes (Granzyme)IBA 05/01/2007 - "Lymphoblastoid cells carrying the D18N mutation are significantly less sensitive to granzyme A-mediated cell death, suggesting a novel role for this caspase-independent form of apoptosis in the pathogenesis of familial chilblain lupus" 05/01/2007 - "A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus." 09/01/2007 - "TREX1 acts in concert with the SET complex in granzyme A-mediated apoptosis, and mutations in TREX1 cause Aicardi-Goutières syndrome and familial chilblain lupus" Get all the results and reference details, order at left...
8.	Vitamin K FDA Link 05/11/1951 - "Treatment of chilblains with 2249 F associated with vitamin K.]" 11/01/1957 - "Phenoxybenzamine and vitamin K in chilblains." Get all the results and reference details, order at left...
9.	Moxisylyte (Thymoxamine)IBA 01/01/1966 - "Thymoxamine in chilblains." 11/01/1980 - "Thymoxamine for Raynaud's disease and chilblains." Get all the results and reference details, order at left...
10.	Retinaldehyde (Retinal)IBA 06/15/2008 - "Aicardi-Goutières syndrome (AGS), Systemic Lupus Erythematosus (SLE), Familial Chilblain Lupus (FCL) and Retinal Vasculopathy and Cerebral Leukodystrophy (RVCL) {a new term encompassing three independently described conditions with a common etiology--Cerebroretinal Vasculopathy (CRV), Hereditary Vascular Retinopathy (HVR) and Hereditary Endotheliopathy, Retinopathy and Nephropathy (HERNS)}--have previously been regarded as distinct entities" 11/14/2008 - "Mutations in TREX1 have been linked to a spectrum of human autoimmune diseases including Aicardi-Goutières syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus, and retinal vasculopathy and cerebral leukodystrophy" Get all the results and reference details, order at left...
35 Drugs and Important Bio-Agents and 37 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Massage (Reflexology) 03/01/2005 - "CONCLUSION: Acupuncture plus massage is superior to dong chuang plaster in therapeutic effect on chilblains." 03/01/2005 - "OBJECTIVE: To compare therapeutic effects of acupuncture plus massage and medicine on chilblains" 03/01/2005 - "Clinical observation on 136 cases of chilblains treated by acupuncture combined with massage]" Get all the results and reference details, order at left...
2.	Therapeutics 08/01/2008 - "SLE therapeutics have good effects on SLE-typical symptoms but not on chilblains themselves" Get all the results and reference details, order at left...
3.	Chemical Sympathectomy 07/01/1979 - "Chilblain lupus erythematosus with response to chemical sympathectomy." Get all the results and reference details, order at left...
4.	Phototherapy (Light Therapy) 01/01/1989 - "We conclude that the ultraviolet phototherapy is of no value in the prophylaxis of chilblains." 01/01/1989 - "A double-blind study of ultraviolet phototherapy in the prophylaxis of chilblains." Get all the results and reference details, order at left...
5.	Occlusive Dressings (Occlusive Dressing) 01/01/1967 - "Chilblains, palmo-plantar hyperhidrosis and occlusive dressings]" Get all the results and reference details, order at left...
5 Therapies and Procedures and 5 more articles analyzed in the Research Interface, order at left...

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License details >>

Price:

$490.00 access via web interface, 1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m", 1 year subscription

Proceed to Checkout >>