Chickenpox

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2150 relevant articles (144 outcomes, 191 trials/studies) found for this Disease

Description: A highly contagious infectious disease caused by the varicella-zoster virus (HERPESVIRUS 3, HUMAN). It usually affects children, is spread by direct contact or respiratory route via droplet nuclei, and is characterized by the appearance on the skin and mucous membranes of successive crops of typical pruritic vesicular lesions that are easily broken and become scabbed. Chickenpox is relatively benign in children, but may be complicated by pneumonia and encephalitis in adults. (From Dorland, 27th ed)

Also Known As:

Chicken Pox; Varicella

Relationship Network

Disease Context: Research Results

Virus Diseases: 1311

DNA Virus Infections: 22

Herpesviridae Infections: 344

Chickenpox: 2150

Related Diseases

1.	Herpes Zoster
2.	Infection
3.	Pneumonia (Pneumonitis)
4.	Measles
5.	Chickenpox

Experts

1.	Seward, Jane F: 5 articles (03/2008 - 02/2002)
2.	Gershon, Anne A: 4 articles (11/2007 - 09/2004)
3.	Smetana, Z: 3 articles (04/2008 - 11/2001)
4.	Mendelson, E: 3 articles (04/2008 - 11/2001)
5.	Gray, Wayne L: 3 articles (03/2008 - 08/2007)
6.	Davis, Kara A: 3 articles (03/2008 - 08/2007)
7.	Traina-Dorge, Vicki: 3 articles (03/2008 - 08/2007)
8.	Wutzler, Peter: 3 articles (10/2007 - 01/2002)
9.	Gray, W L: 3 articles (01/2007 - 11/2001)
10.	Goldman, Gary S: 3 articles (09/2006 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chickenpox:

1.	Acyclovir (Aciclovir)FDA LinkGeneric 03/01/1998 - "In our study application of acyclovir in that age group provided good results as for prevention and treatment of complications of chickenpox if already manifested." 01/01/2007 - "The patient with chickenpox was treated successfully with acyclovir without complication" 03/01/1995 - "We conclude that early treatment with acyclovir was beneficial whereas late therapy had limited effect in reducing the severity of cutaneous lesions in patients with varicella." 01/01/1988 - "Intravenous acyclovir is effective for varicella in adults and immunocompromised children, causing more rapid resolution of the illness and fewer complications" 01/01/1998 - "The nucleoside analogue aciclovir (syn: acyclovir, Zovirax) is effective in inhibiting replication of VZV when given at a dosage higher than that required for treatment of HSV, and is currently the only available and approved treatment for varicella in the U.K" Order ALL the reference details at left...
2.	Chickenpox Vaccine (Vaccine, Varicella)IBA 03/01/2008 - "When administered after exposure, varicella vaccine was highly effective in preventing or modifying varicella" 12/02/2004 - "The varicella vaccine Varilrix may not be effective in preventing varicella when administered after household exposure, although it is highly effective in ameliorating the disease in those who acquire it under these circumstances." 02/01/2004 - "CONCLUSIONS: Administration of either one or two injections of varicella vaccine to healthy children results in long term protection against most varicella disease" 01/01/2000 - "CONCLUSION: When used within 36 hours after exposure to varicella in a setting where close contact occurred, varicella vaccine was highly effective in preventing further disease" 11/12/1997 - "CONCLUSIONS: Varicella vaccine administered under routine conditions in physicians' offices was highly effective in preventing varicella in an outbreak characterized by intense exposure" Order ALL the reference details at left...
3.	VaccinesIBA 04/01/2000 - "New and improved" varicella vaccines that may be more effective than the current vaccine and can be stored at refrigerator temperatures may soon become available in the United States." 02/01/2004 - "OBJECTIVES: The low cost of safe and effective vaccines prompted a cost-containment evaluation of a nationwide vaccination campaign against varicella" 06/01/2003 - "The varicella vaccines available in the market are safe and effective" 12/01/2000 - "The availability of safe and effective vaccines has renewed interest in the epidemiology of varicella worldwide" 01/01/1985 - "In addition, a survey of the published literature on clinical studies performed on as yet unlicensed Oka-strain varicella vaccines produced by the Biken Institute and Merck Sharp & Dohme is presented." Order ALL the reference details at left...
4.	Immunoglobulins (Immunoglobulin)IBA 02/24/1979 - "Comparison between 157 children treated with defibrinated convalescent plasma and 257 children treated with specific immunoglobulins revealed the improved effectiveness of the latter treatment in the prevention of chickenpox" 04/30/2005 - "Patients with current varicella, immunodeficiency, immunoglobulin treatment in the previous 6 months, or significant language barriers were excluded" 05/01/1990 - "Immunoglobulin prophylaxis for infants exposed to varicella in a neonatal unit." 09/01/1985 - "Chickenpox prevention in patients at risk with a special immunoglobulin]" 01/01/1982 - "The protective value of this varicella-immunoglobulin compound is much greater than any other known so far [16]." Order ALL the reference details at left...
5.	UniversalIBA 10/16/2008 - "All universal varicella vaccination strategies including toddlers (with or without an adolescent catch-up programme) turned out to be highly effective in reducing the burden of disease due to varicella" 03/01/2006 - "Universal varicella vaccination has been highly effective in reducing morbidity and hospitalizations due to varicella, a strategy that has proven to be cost effective in many regions when the societal-perspective is considered in the analysis" 11/01/2005 - "Experience with universal varicella vaccination of children in the USA over the last 10 years has shown that the vaccine is safe and highly effective in reducing varicella-related disease" 07/01/2005 - "The universal varicella program has proven effective in terms of reducing the number of reported verified varicella cases by 85%, from 2,934 in 1995 to 412 in 2002" 11/18/2008 - "This study conducts a cost-effectiveness analysis of a childhood universal varicella vaccination program in Brazil" Order ALL the reference details at left...
6.	Intravenous Immunoglobulins (IVIG)FDA Link 02/01/2001 - "None of ten infants receiving both IVIG and ACV contracted varicella" 02/01/2001 - "Of four infants receiving IVIG alone, two developed clinical varicella" 10/01/1992 - "None of the five children developed varicella following IVIG infusion" 02/01/1992 - "Treatment with high doses of intravenous immunoglobulins in thrombopenia associated with varicella]" 03/01/2000 - "During the last fifteen years, indications of IVIg in the prophylactic treatment of infections have been well defined: a) primary antibody deficiency; b) multiple myeloma and chronic lymphocytic leukemia with hypogammaglobulinemia and recurrent bacterial infections; c) bone marrow allograft; d) childhood AIDS; e) chicken pox seroprophylaxis in immunosuppressed patients and pregnant women" Order ALL the reference details at left...
7.	sorivudineIBA 08/01/1996 - "The antiviral and clinical efficacy of sorivudine in adults with varicella was evaluated in a double-blind, placebo-controlled randomized trial" 04/01/1992 - "Oral bioavailability and anti-simian varicella virus efficacy of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) in monkeys." 08/01/1996 - "Treatment of adult varicella with sorivudine: a randomized, placebo-controlled trial." 04/01/1992 - "In the present study, pharmacokinetic parameters and the efficacy of BV-araU against infection with simian varicella virus (SVV) were evaluated in African green monkeys" 01/01/1993 - "Several new agents for varicella-zoster therapy are being evaluated; brovavir is a new agent currently being compared to placebo in the treatment of adult varicella." Order ALL the reference details at left...
8.	InterferonsIBA 01/01/1983 - "The efficacy of interferon prophylaxis in the simian varicella model supports its continued evaluation for the management of human varicella in high-risk patients." 01/01/1990 - "Interferon (IFN) alpha was detected in the serum of children with varicella" 01/01/1990 - "Production of circulation interferon in children with varicella." 04/01/1984 - "Although interferon has not yet been used in an attempt to prevent or modify varicella in humans, it has been used successfully to abort an outbreak of simian varicella in a monkey colony" 01/01/1983 - "During the 14 days beginning with the first day of treatment, the attack rate for simian varicella was 14.3% (two of 14) among interferon recipients compared to 70% (nine of 13) among placebo recipients (P less than 0.025)" Order ALL the reference details at left...
9.	AntibodiesIBA 01/01/1985 - "The vaccine was safe (no side effects) in healthy individuals, highly immunogenic (dose-dependent induction of humoral antibodies and specific cell-mediated immune response), and highly protective against clinical varicella" 08/01/2007 - "The objective of this study was to assess the seroprevalence of varicella zoster virus (VZV) antibodies in military recruits in Singapore and to ascertain the predictive value of a self-reported history of varicella" 09/01/2005 - "This study assessed the seroprevalence of varicella antibodies in children and adolescents in Spain and evaluated the reliability of two methods for detecting susceptible individuals: (1) parental-reported history of varicella and (2) medically-documented histories maintained by the pediatrician" 06/18/2005 - "A serologic study in order to determine antibodies againts varicella was carried out for people without varicella vaccination or disease history" 02/10/2005 - "The objective of this study was to assess the seroprevalence of varicella antibodies in healthcare workers and students of healthcare professions and to determine the validity of the self-reported varicella history for detecting susceptible subjects" Order ALL the reference details at left...
10.	Vidarabine (Vira-A)FDA Link 07/01/1982 - "In order to assess further the clinical usefulness of vidarabine therapy of chicken pox, a double-blind, placebo-controlled trial was performed in immunocompromised patients" 07/01/1982 - "Vidarabine therapy of varicella in immunosuppressed patients." 01/01/1984 - "Although a spontaneous improvement is known to occur in patients with varicella thrombocytopenia, the rapid clinical improvement after the Ara-A administration is suggestive for its beneficial effect in the presented patient." 11/01/1984 - "Initial clinical trials show the drug to be well tolerated and to be more effective than adenine arabinoside against varicella zoster in the immunosuppressed patient" 12/01/1989 - "Vidarabine was given intravenously to eight patients with varicella and to eight with herpes zoster at a dose of 10 mg/kg/day" Order ALL the reference details at left...

Therapies and Procedures

1.	Transplants (Transplant) 03/01/2006 - "The patient, who was re-transplanted in the absence of signs of varicella zooster reactivation, is now well and disease free 3 yr after second liver transplant." 08/01/2003 - "Further prospective randomized trials are required to evaluate the management of pediatric liver transplant patients infected with varicella." 08/01/2003 - "There have been few previous studies monitoring the course of pediatric liver transplant patients with acute varicella" 04/01/2005 - "Indications for varicella vaccination post-transplant." 08/01/2003 - "METHODS: A retrospective chart review was carried out based on discharge diagnoses of orthotopic liver transplant and varicella among pediatric patients (age range, birth-18 years) admitted to the UCLA Medical Center between 1985 and 2001" Order ALL the reference details at left...
2.	Drug Therapy (Chemotherapy) 01/01/1992 - "The control group comprised 92 ALL and 25 NHL patients receiving chemotherapy in remission who were nonvaccinated and susceptible to varicella" 09/01/2008 - "We prospectively evaluated the feasibility of a varicella vaccination programme of household contacts of varicella-negative children receiving antineoplastic chemotherapy" 05/01/1996 - "Exposures and varicella resulted in significant omission or delay in chemotherapy" 01/01/1992 - "Thus we conclude that the vaccine can be safely used in children with ALL or NHL under chemotherapy and can effectively protect such children from varicella." 12/01/1989 - "These results should serve as a caution that vaccination of these children should be undertaken only with full knowledge of their therapeutic regimen and a thorough clinical understanding of the competing risks of varicella, vaccination and modification of the child's chemotherapy." Order ALL the reference details at left...
3.	Day Care (Partial Hospitalization) 05/01/2005 - "CONCLUSIONS: Our data demonstrate that the varicella Oka/GSK vaccine used in clinical practice is highly effective in prevention of varicella (especially moderate/severe disease) among children, including those attending day-care centers." 04/01/2006 - "METHODS: Descriptive study carried out through inquiries with parents of 664 children who acquired varicella after admission to day care centers in Taubaté (population: 244,165, census of 2004), a prosperous city in the State of São Paulo" 11/01/1998 - "This study emphasizes the important socioeconomic impact of varicella in the day care setting in France." 11/01/1998 - "Cost of varicella in France: a study in day care centers." 06/25/2008 - "The effectiveness of varicella vaccination during an outbreak in a children's day-care center." Order ALL the reference details at left...
4.	Chemoprevention 12/01/1986 - "In the case of influenza and varicella immune prophylaxis and chemotherapy/chemoprophylaxis are possible" 03/01/1986 - "After a discussion of the principles of antiviral chemotherapy, treatment and chemoprophylaxis of the following virus infections are reviewed in detail: the various manifestations of herpes simplex virus infections, varicella-zoster, cytomegalovirus infections, Epstein-Barr virus infections, laryngeal papillomas, and influenza A" 10/01/1997 - "The issues most frequently addressed in a travel clinic include treatment of traveler's diarrhea, malaria chemoprophylaxis, and immunizations, for hepatitis A, typhoid fever, tetanus/diphtheria, influenza, pneumococcus, hepatitis B, polio, meningococcus, measles, mumps, rubella, varicella, and rabies" 12/01/2000 - "While oral acyclovir chemoprophylaxis is probably beneficial in populations with chicken pox." 01/01/1992 - "Early, aggressive therapy with acyclovir seems to abort the catastrophic consequences of varicella pneumonia, while oral acyclovir chemoprophylaxis is probably beneficial in high-risk populations with chickenpox." Order ALL the reference details at left...
5.	Kidney Transplantation 02/01/2001 - "Pretransplant varicella vaccination is cost-effective in pediatric renal transplantation." 08/01/1998 - "Varicella after kidney transplantation." 08/01/1997 - "We have examined the current incidence and mortality of varicella requiring hospitalization in pediatric patients in the first year after kidney transplantation through a multi-center retrospective cohort study" 04/01/1994 - "We consider that seronegative children who are candidates for renal transplantation must be protected against varicella by attenuated varicella vaccination" 01/01/1987 - "Five of 610 adults developed chickenpox between 35 days and 9.2 years after renal transplantation, and only one patient survived" Order ALL the reference details at left...

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