Chiari-Frommel Syndrome

A POSTPARTUM condition consists of persistent lactation (GALACTORRHEA) and AMENORRHEA in patients not BREAST FEEDING.

Also Known As:

Frommel Disease; Chiari Frommel Syndrome; Disease, Frommel; Disease, Frommel's; Syndrome, Chiari-Frommel; Frommel's Disease

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Urogenital Diseases: 126
- Female Urogenital Diseases and Pregnancy Complications
  - Pregnancy Complications: 2961
    - Puerperal Disorders: 15
      - Lactation Disorders: 77
        Galactorrhea: 770
        Chiari-Frommel Syndrome: 11
Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Breast Diseases: 1550
    - Lactation Disorders: 77
      - Galactorrhea: 770
        Chiari-Frommel Syndrome: 11

Related Diseases

1.	Galactorrhea
2.	Amenorrhea
3.	Pituitary Neoplasms (Pituitary Adenoma)
4.	Nonpuerperal galactorrhea

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chiari-Frommel Syndrome:

1.	ProlactinIBA 07/01/1972 - "Prolactin in the male; hypophyseal disconnection; Chiari-Frommel syndrome]." 11/01/1977 - " There were 4 patients with the Chiari-Frommel syndrome; their mean serum prolactin level was 435 ng/ml. 5 patients had pituitary tumors; galactorrhea was present in 3 of them. " 02/01/1975 - "Twenty-four-hour secretory patterns of gonadotropins and prolactin in a case of Chiari-Frommel syndrome." 02/01/1975 - "Plasma LH, FSH and prolactin secretory patterns were derived from the measurement of 20-min interval plasma samples obtained during a complete 24-h period in a patient with persistent postpartum amenorrhea and galactorrhea (Chiari-Frommel syndrome), before and after clomiphene citrate therapy. " 01/20/1988 - "In order to clarify the mechanism(s) which causes galactorrhea and amenorrhea in patients with Galactorrhea-Amenorrhea Syndrome (GAS) (Group A, n = 20), composed of Chiari-Frommel Syndrome (CFS) (Subgroup I, n = 3), Argonz-del Castillo Syndrome (ADCS) (Subgroup II, n = 5) and Drug-induced Galactorrhea-Amenorrhea (DIG) (Subgroup III, n = 12), we analysed basal plasma prolactin (PRL) and gonadotropin levels and their responsiveness to TRH and LH-RH, respectively in GAS patients. "
2.	Clomiphene (Clomifene)FDA LinkGeneric 08/01/1970 - "[Case of Chiari-Frommel syndrome with Clomid-induced ovulation and pregnancy--3rd action mechanism of Clomid]." 05/30/1968 - "Apropos of a case of the Chiari-Frommel syndrome treated with clomiphene]." 09/15/1963 - "PREGNANCY FOLLOWING CLOMIPHENE-INDUCED OVULATION IN CHIARI-FROMMEL SYNDROME." 02/01/1975 - "Plasma LH, FSH and prolactin secretory patterns were derived from the measurement of 20-min interval plasma samples obtained during a complete 24-h period in a patient with persistent postpartum amenorrhea and galactorrhea (Chiari-Frommel syndrome), before and after clomiphene citrate therapy. "
3.	GonadotropinsIBA 11/01/1967 - "Birth of septuplets following human gonadotropin administration in Chiari-Frommel syndrome." 02/01/1975 - "Twenty-four-hour secretory patterns of gonadotropins and prolactin in a case of Chiari-Frommel syndrome." 01/20/1988 - "In order to clarify the mechanism(s) which causes galactorrhea and amenorrhea in patients with Galactorrhea-Amenorrhea Syndrome (GAS) (Group A, n = 20), composed of Chiari-Frommel Syndrome (CFS) (Subgroup I, n = 3), Argonz-del Castillo Syndrome (ADCS) (Subgroup II, n = 5) and Drug-induced Galactorrhea-Amenorrhea (DIG) (Subgroup III, n = 12), we analysed basal plasma prolactin (PRL) and gonadotropin levels and their responsiveness to TRH and LH-RH, respectively in GAS patients. "
4.	Medroxyprogesterone Acetate (Depo-Provera)FDA LinkGeneric 03/01/1964 - "CHIARI-FROMMEL SYNDROME: MEDROXYPROGESTERONE ACETATE THERAPY."
5.	SteroidsIBA 03/01/1968 - "[Steroid examinations in the Chiari-Frommel syndrome]."
6.	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/20/1988 - "In order to clarify the mechanism(s) which causes galactorrhea and amenorrhea in patients with Galactorrhea-Amenorrhea Syndrome (GAS) (Group A, n = 20), composed of Chiari-Frommel Syndrome (CFS) (Subgroup I, n = 3), Argonz-del Castillo Syndrome (ADCS) (Subgroup II, n = 5) and Drug-induced Galactorrhea-Amenorrhea (DIG) (Subgroup III, n = 12), we analysed basal plasma prolactin (PRL) and gonadotropin levels and their responsiveness to TRH and LH-RH, respectively in GAS patients. "
7.	Bromocriptine (Parlodel)FDA LinkGeneric 03/01/1974 - "Successufl ovulation and pregnancy achieved by cb-154 (2-br-alpha-ergocryptine) in a woman with Chiari-Frommel syndrome."

Therapies and Procedures

Therapeutics

03/01/1964 - "CHIARI-FROMMEL SYNDROME: MEDROXYPROGESTERONE ACETATE THERAPY."
02/01/1975 - "Plasma LH, FSH and prolactin secretory patterns were derived from the measurement of 20-min interval plasma samples obtained during a complete 24-h period in a patient with persistent postpartum amenorrhea and galactorrhea (Chiari-Frommel syndrome), before and after clomiphene citrate therapy. "