|1.||Dyspnea (Shortness of Breath)
|4.||Myocardial Ischemia (Ischemic Heart Diseases)
|1.||Hoffmann, Udo: 26 articles (11/2015 - 11/2006)|
|2.||Mueller, Christian: 24 articles (01/2016 - 08/2009)|
|3.||Cullen, Louise: 24 articles (12/2015 - 03/2011)|
|4.||Twerenbold, Raphael: 22 articles (12/2015 - 08/2009)|
|5.||Reichlin, Tobias: 21 articles (12/2015 - 08/2009)|
|6.||Nagurney, John T: 21 articles (11/2015 - 11/2006)|
|7.||Bamberg, Fabian: 21 articles (11/2015 - 08/2008)|
|8.||Hollander, Judd E: 20 articles (01/2016 - 02/2003)|
|9.||Truong, Quynh A: 20 articles (11/2015 - 03/2009)|
|10.||Than, Martin: 20 articles (10/2015 - 03/2011)|
|1.||Nitroglycerin (Dynamite)FDA LinkGeneric
08/01/1976 - "As the brachial artery pressure rose in one patient, chest pain and marked ST-segment elevation occurred which were relieved by nitroglycerin. "
01/01/1994 - "Six patients had a significant improvement of symptoms confirmed by a reduced incidence of chest pain and decreased used of nitroglycerin. "
01/01/1994 - "Nitroglycerin was beneficial in 41 patients (49%; 95% CI, 38-60%): 37 patients (45%) had relief or reduction in the severity of chest pain and 4 patients (5%) had other beneficial effects. "
04/01/1991 - "With evidence of altered vasomotor tone when compared to no therapy however it was beneficial in terms of reduction in chest pain and requirement for glyceryl trinitrate during daily life.(ABSTRACT TRUNCATED AT 250 WORDS)"
02/01/1986 - "When compared to the MED patients at time of follow-up, successful PTCA patients experienced less angina (13% vs 47%; p = 0.003), used less nitroglycerin (25% vs 73%, p = 0.003), were hospitalized less often for chest pain (8% vs 31%; p = 0.02), and subjectively felt their condition had improved (96% vs 20%; p less than 0.001). "
|2.||Biological Markers (Surrogate Marker)IBA
05/01/2013 - "New serological biomarkers, such as troponins, have improved the diagnosis of ACS; however, the diagnosis of ACS can still be difficult as there is marked heterogeneity in its presentation and significant overlap with other disorders presenting with chest pain. "
09/01/2014 - "The traditional strategy of evaluating acute chest pain by hospital or ED observation over a period of several hours, serial electrocardiography and cardiac biomarkers, and subsequent diagnostic testing such as physiologic stress testing is safe and effective. "
01/01/2014 - "The secondary endpoints include <25% improvement in perfusion defect size, chest pain frequency, ST depression in stress test, Duke score in stress test, quality of life (QoL) assessment by SF-36 questionnaire, sexual dysfunction assessment by BISF-W (Brief Index of Sexual Functioning for Women) self-assessment questionnaire, and biomarkers for endothelial function. "
01/01/2012 - "Biomarkers of plaque instability do not seem helpful in the early diagnosis of AMI but may provide some incremental value in the risk stratification of patients with acute chest pain."
07/01/2010 - "However, there is limited knowledge regarding the utility of this score for long-term risk prediction in unselected patients with acute chest pain and whether it might be improved by the integration of nonnecrosis biomarkers. "
10/01/1995 - "This potential for 100% predictability in excluding AMI by the use of serial myoglobin determinations will be very helpful in the correct triage of patients presenting with acute chest pain."
07/01/2010 - "The automated H-FABP (by LTIA) is superior to cTnT, CK-MB, myoglobin, and H-FABP (by ELISA) tests for the diagnosis of AMI in patients admitted within 4 hours from the onset of chest pain."
07/24/2005 - "Our preliminary clinical data suggests that FABP had a better diagnostic performance (sensibility = 100%) than myoglobin (sensibility = 75%) to detect AMI in the first hours after the onset of the chest pain and myoglobin/CAIII ratio (specificity = 92.9%) improved the myoglobin specificity. "
06/01/2004 - "Reevaluation of myoglobin for acute chest pain evaluation: would false-positive results on "first-draw" specimens lead to increased hospital admissions?"
06/01/1996 - "A prospective, observational test performance study for the recognition of AMI was done using serial myoglobin assays of 42 admitted chest pain patients at a large, urban teaching hospital ED. "
01/01/2001 - "In a previous multicenter study of chest pain patients presenting to the emergency department (ED), this test demonstrated high negative predictive value and sensitivity in the sample collected at presentation for predicting cardiac troponin I (cTnI)-negative or cTnI-positive results 6-24 h later. "
02/01/1998 - "Cardiac troponin I is very useful for the studying ischemic chest pain without a definitive diagnostic ECG nor biochemical data, resulting in a high sensitivity and specificity for myocardial ischemic injury detection. "
03/01/2014 - "We assessed the diagnostic efficacy of plasma Myeloperoxidasis (MPO) alone or in combination with cardiac troponin I (cTnI) for detecting ACS in patients presenting with chest pain initiating within 24 h before the hospital admission. "
06/01/2011 - "We assessed the diagnostic efficacy of plasma MPO alone or in combination with cardiac troponin I (cTnI) for detecting ACS in patients presenting with chest pain initiating within 6h before the hospital admission. "
10/01/2013 - "The study objective was to validate a new high-sensitivity troponin I (hs-TnI) assay in a clinical protocol for assessing patients who present to the emergency department with chest pain. "
09/01/2003 - "The administration of a calcium antagonist and nitrate was effective for ameliorating chest pain with no cardiovascular events during the follow up period of more than 3 years. "
04/01/2003 - "However, his symptoms, including chest pain, gradually improved and the ECG returned to normal in accordance with a fall in his serum calcium level. "
01/01/2001 - "She was medicated with calcium antagonists, which reduced the frequency of chest pain episodes. "
03/01/1986 - "Reintroduction of calcium blockade with this drug eliminated the chest pain and resulted in normalization of the stress ECG. "
03/01/2015 - "Use of coronary artery calcium scanning beyond coronary computed tomographic angiography in the emergency department evaluation for acute chest pain: the ROMICAT II trial."
|6.||Nifedipine (Adalat)FDA LinkGeneric
01/01/1997 - "These data support our hypothesis that smoking patients treated with nifedipine could be at a potential risk in developing a high pain threshold and missing the first sign of heart attack--a chest pain."
03/01/1992 - "A 60-year-old man with atypical chest pain not submitted to adequate diagnostic procedures was treated on an empirical basis with nifedipine 20 mg b.i.d. "
01/01/1991 - "However, placebo was superior to nifedipine capsules (plasma concentration 58 nmol/l) both in the time to onset of chest pain and total exercise time. "
01/01/1991 - "Six h after dosing the time of onset of chest pain and total exercise time were longer and total work was significantly higher during both nifedipine-ER (plasma concentration 260 nmol/l) and placebo treatment than after nifedipine capsules (plasma concentration 78 nmol/l). "
03/01/1989 - "A 63-year-old woman had chest pain that worsened when nifedipine was given. "
12/28/2011 - "Introduction of highly sensitive troponin assays into clinical practice has substantially improved the evaluation of patients with chest pain. "
12/01/2015 - "Addition of copeptin to troponin does not have significant improvement of the diagnostic accuracy of ACS in patients presented with chest pain."
01/01/2015 - "High-sensitivity troponin has significantly greater early sensitivity and NPV for the diagnosis of AMI at the cost of specificity and positive predictive value, which may enable early rule in/out of AMI in patients with chest pain. "
03/01/2006 - "Stress echocardiography is superior to exercise ECG in the risk stratification of patients presenting with acute chest pain with negative Troponin."
10/01/2011 - "Two recent clinical trials showed that adding copeptin to a conventional cardiac troponin assay improved diagnostic performance for patients with chest pain early after symptom onset. "
|8.||Propranolol (Inderal)FDA LinkGeneric
07/01/1983 - "Although most of these effects were seen with medium-dose propranolol, higher doses provided additional relief of chest pain and S-T segment depression, and further improved global and regional LV function in several patients."
04/01/1982 - "Propranolol removed the gradient during cardiac catheterization and relieved the exertional chest pain clinically."
01/01/1976 - "Severe chest pain, unresponsive to conventional therapy in four patients, was relieved by propranolol. "
07/01/2002 - "However, after testing, upon injection of propranolol, the patient suffered chest pain associated with ST elevation and severe regional systolic abnormalities. "
07/01/1992 - "Coronary angiography performed during the ischaemic episode showed patency of coronary arteries; ST-segment elevation and chest pain regressed after propranolol administration. "
|9.||Omeprazole (Esomeprazole)FDA LinkGeneric
10/01/1997 - "Patients on omeprazole obtained significantly more improvement in the fraction of chest pain days (P = 0.006) and severity (P = 0.032) when compared to placebo. "
09/01/1999 - "Among patients with noncardiac chest pain, diagnostic strategies that begin with the omeprazole test result in reduced costs, improved diagnostic certainty, and a greater proportion of symptom-free patients at 1 year than do traditional strategies that begin with invasive diagnostic tests."
01/01/2013 - "The aim of this study was to evaluate the efficacy of esomeprazole in primary-care treatment of patients with unexplained chest pain stratified for frequency of reflux/regurgitation symptoms. "
10/01/2002 - "Seventy-one percent of patients in the omeprazole arm reported improved chest pain, whereas only 18% in the placebo arm did. "
01/01/2013 - "Acid-suppressive therapy with esomeprazole for relief of unexplained chest pain in primary care: a randomized, double-blind, placebo-controlled trial."
|10.||Diltiazem (Cardizem)FDA LinkGeneric
07/01/1984 - "Although oral diltiazem has minimal effect on baseline esophageal contractions, our chronic study suggests it may modify transient increases in neuromuscular tone associated with esophageal chest pain. "
01/01/1996 - "After the administration of diltiazem, the chest pain score was significantly decreased in group D1 (control: 5.1 +/- 3.6, posttreatment: 3.8 +/- 3.1, P < 0.01) and group D2 (3.4 +/- 2.5 vs 2.5 +/- 2.0, P < 0.01), but not in group C (4.1 +/- 3.1 vs 3.7 +/- 3.3, difference not significant). "
03/01/1991 - "Mean chest pains scores were significantly (p less than 0.05) lower with diltiazem therapy than with placebo. "
03/01/1990 - "No attacks of chest pain were experienced after treatment with 200 mg of sustained-release diltiazem daily. "
07/01/1984 - "During an eight-week open-labeled study, diltiazem 90 mg QID significantly (P less than 0.01) improved symptoms of chest pain and dysphagia. "
|1.||Coronary Artery Bypass (Coronary Artery Bypass Surgery)
04/01/1976 - "Because of recurrent attacks of severe chest pain, coronary artery bypass surgery was performed which failed to result in significant improvement of her symptoms. "
03/02/1991 - "The proportion of patients complaining of chest pain fell from 90% (88/98) before grafting to 19% (17/89) at one year after coronary artery bypass grafting, when 91% (81/89) patients maintained that their condition was either completely better or definitely improved. "
05/01/2015 - "A woman in her 50s with recent coronary artery bypass grafting presenting with right-sided chest pain."
01/01/2010 - "To describe changes in chest pain and dyspnoea during a period of 15 years after coronary artery bypass grafting (CABG) and to define factors at the time of operation that were associated with the occurrence of these symptoms after 15 years. "
01/01/2010 - "Symptoms of chest pain and dyspnoea during a period of 15 years after coronary artery bypass grafting."
05/01/1999 - "The exercise test was interrupted less often because of chest pain (23 vs. 41%, P = 0.03) and improvement in exercise test variables during the follow-up period was significantly greater in subjects with patent grafts (P<0.002). "
01/01/1981 - "Transverse radiotomography, a non-invasive technique, is very useful in operated patients with atypical chest pain and in those with recurrent angina in whom obstruction of the graft is feared. "
10/01/1987 - "To assess the efficacy of magnetic resonance (MR) imaging in evaluating graft patency after coronary bypass surgery, 20 patients who had prior surgery (average 5.5 years, range 1.5 to 14) and recent cardiac catheterization because of chest pain were studied. "
03/25/2003 - "This proof-of-concept study suggests that noninvasive MRI detection of stenotic grafts in patients who present with recurrent chest pain after CABG may be useful in selecting those in need of an invasive procedure."
08/01/1983 - "The study was limited in only three patients because of incisional chest pain (one patient) or multiple metal clips attached to the graft (two patients). "
03/01/2015 - "After treatment, 75% (27/36) of CSF patients were free of chest pain. "
10/01/2014 - "Before and after treatment, we assessed the severity (intensity and frequency) of chest pain, quality of life, and anxiety and depression by means of specific questionnaires. "
06/01/2012 - "After treatment for 1-4 years, patients with functional chest pain showed significant improvements in symptoms compared with those who were not treated. "
02/01/2011 - "After treatment, there was a significant decrease in chest pain and somatization. "
09/01/2009 - "Chest pain relief was detected in 38 patients after treatment (90%). "
|4.||Drug Therapy (Chemotherapy)
07/01/1987 - "This study suggests that identification of the esophagus as the cause of chest pain coupled with supportive intervention may be more effective than drug therapy in improving these patients' chest pain."
12/01/2014 - "Refractory angina is characterized by repeated attacks of chest pain in patients on maximal anti-anginal pharmacotherapy, with a professional conscensus that further surgical or radiological revascularization would be futile. "
09/01/2012 - "Updating an institutional chest pain algorithm: incorporating new evidence on emerging pharmacotherapy."
05/01/2012 - "Two days after initiation of the first course of chemotherapy, the patient reported typical chest pain. "
03/01/2011 - "We present our updated chest pain algorithm with a brief review of the rapidly evolving changes in adjunctive pharmacotherapy for PCI, and provide rationale for the changes that we have made to our institutional protocol. "
01/01/1986 - "Chest pain was relieved or decreased more frequently in the patients receiving thrombolytic therapy vs. those untreated; 21 of 55 vs. 21 of 95 respectively (p = 0.04). "
11/01/1993 - "These findings suggest that the assessment of chest pain before and after thrombolytic therapy is a readily available, useful indicator of the efficacy of the therapy."
05/01/1991 - "Patients who have chest pain without electrocardiographic ST elevation are not candidates for thrombolytic therapy in most clinical trials. "
05/01/1989 - "In our study, paramedics evaluated patients who had chest pain with a 12-lead ECG transmitted by cellular telephone and a checklist for inclusion and exclusion criteria for thrombolytic therapy. "
12/01/2014 - "We retrospectively evaluated 232 consecutive patients with a diagnosis of first STEMI who were administered thrombolytic therapy within 12 hours of onset of chest pain. "