Chenodeoxycholic Acid (Chenix)

A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.

Also Known As:

Chenix; Chenodiol; Chenique Acid; Chenofalk; Chenophalk; Henohol; Quenobilan; Quenocol; Sodium Chenodeoxycholate; Acid, Chenic; Acid, Chenique; Acid, Chenodeoxycholic; Acid, Gallodesoxycholic; Chenodeoxycholate, Sodium; Chenic Acid; Chenodeoxycholate; Gallodesoxycholic Acid; Cholan-24-oic acid, 3,7-dihydroxy-, (3alpha,5beta,7alpha)-

Networked: 877 relevant articles (48 outcomes, 106 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Bile Acids and Salts: 11432
      - Cholic Acids: 14
        Deoxycholic Acid: 963
        Chenodeoxycholic Acid: 877
        chenodeoxycholate sulfate conjugate: 528
        obeticholic acid: 319
        Glycochenodeoxycholic Acid: 76
        Taurochenodeoxycholic Acid: 76
        HS 1200: 13
        3,7-dihydroxycholane-24-sulfonate: 8
        HS-1199: 7
        23-norchenodeoxycholic acid: 1
        3,7-dihydroxy-25,26-bishomocholane-26-sulfonate: 1
        3-oxo-7-hydroxychol-4-enoic acid: 1
        homochenodeoxycholic acid: 1
        sodium 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate: 1
        1-hydroxychenodeoxycholic acid
        16-hydroxychenodeoxycholic acid
        23-hydroxychenodeoxycholic acid
        24-norchenodeoxycholic acid
        3,7-dihydroxy-12-oxocholanoic acid
        3,7-dihydroxy-24-norcholane-23-sulfonate
        3,7-dihydroxy-25-homocholane-25-sulfonate
        3,7-dihydroxychol-5-enoic acid
        3-glucosido-chenodeoxycholic acid
        3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate
        7alpha,12alpha-dihydroxy-5alpha-cholan-3-one 24-oic acid
        avicholic acid
        chenodeoxycholyl-2-(4-N-nitrobenzoxadiazolyl)aminobutyl-glycine
        chenodeoxycholyl-nitrobenzoxadiazolyl-lysine
        chenodeoxycholyllysylrhodamine
        chenodeoxycholyltyrosine
        deoxycholyl-L-lysyl-methylester
        methyl 3,7-dihydroxychol-4-en-24-oate
        methyl 3,7-dihydroxycholanate
        methyl-3beta-hydroxy-5alpha,6alpha-epoxycholanate
        N-(2-aminoethyl)-3,7-dihydroxycholan-24-amide
        N-chenodeoxycholyl-2-fluoro-beta-alanine
        sarcochenodeoxycholic acid
    - Cholanes
      - Cholic Acids: 14
        Deoxycholic Acid: 963
        Chenodeoxycholic Acid: 877
        chenodeoxycholate sulfate conjugate: 528
        obeticholic acid: 319
        Glycochenodeoxycholic Acid: 76
        Taurochenodeoxycholic Acid: 76
        HS 1200: 13
        3,7-dihydroxycholane-24-sulfonate: 8
        HS-1199: 7
        23-norchenodeoxycholic acid: 1
        3,7-dihydroxy-25,26-bishomocholane-26-sulfonate: 1
        3-oxo-7-hydroxychol-4-enoic acid: 1
        homochenodeoxycholic acid: 1
        sodium 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate: 1
        1-hydroxychenodeoxycholic acid
        16-hydroxychenodeoxycholic acid
        23-hydroxychenodeoxycholic acid
        24-norchenodeoxycholic acid
        3,7-dihydroxy-12-oxocholanoic acid
        3,7-dihydroxy-24-norcholane-23-sulfonate
        3,7-dihydroxy-25-homocholane-25-sulfonate
        3,7-dihydroxychol-5-enoic acid
        3-glucosido-chenodeoxycholic acid
        3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate
        7alpha,12alpha-dihydroxy-5alpha-cholan-3-one 24-oic acid
        avicholic acid
        chenodeoxycholyl-2-(4-N-nitrobenzoxadiazolyl)aminobutyl-glycine
        chenodeoxycholyl-nitrobenzoxadiazolyl-lysine
        chenodeoxycholyllysylrhodamine
        chenodeoxycholyltyrosine
        deoxycholyl-L-lysyl-methylester
        methyl 3,7-dihydroxychol-4-en-24-oate
        methyl 3,7-dihydroxycholanate
        methyl-3beta-hydroxy-5alpha,6alpha-epoxycholanate
        N-(2-aminoethyl)-3,7-dihydroxycholan-24-amide
        N-chenodeoxycholyl-2-fluoro-beta-alanine
        sarcochenodeoxycholic acid

Experts

1.	Suh, Hongsuk: 9 articles (05/2009 - 03/2003)
2.	Yoo, Young Hyun: 9 articles (05/2009 - 03/2003)
3.	Kim, Nam Deuk: 9 articles (10/2008 - 03/2003)
4.	Dotti, Maria Teresa: 6 articles (04/2020 - 03/2013)
5.	Mignarri, Andrea: 6 articles (04/2020 - 03/2013)
6.	Verrips, Aad: 5 articles (11/2020 - 01/2016)
7.	Choi, Yung Hyun: 5 articles (10/2008 - 09/2003)
8.	Federico, Antonio: 4 articles (04/2020 - 03/2013)
9.	Staels, Bart: 4 articles (03/2008 - 02/2003)
10.	Al-Salami, Hani: 3 articles (01/2021 - 09/2016)

Related Diseases

1.	Gallstones (Gallstone) 03/01/1982 - "Of 125 patients with radiolucent gallstones in functioning gallbladders treated with chenodeoxycholic acid (CDCA) between 1971 and 1977, 47 showed complete gallstone dissolution--an overall efficacy of 38%. " 01/01/1980 - "Chenodeoxycholic acid (CDCA) is an effective treatment for dissolving gallstones but experimental studies have suggested that it might be hepatotoxic. " 06/01/1990 - "One hundred and twelve patients with radiolucent gallstones entered the study; 54 received chenodeoxycholic acid (CDCA) and 58 ursodeoxycholic (UDCA) at dosage of 15 mg/kg/daily. " 01/01/1985 - "The Sunnybrook Gallstone Study was a randomized, double-blind, controlled trial of chenodeoxycholic acid treatment over 2 years in 160 patients with radiolucent gallstones. " 01/01/1985 - "The Sunnybrook Gallstone Study: a double-blind controlled trial of chenodeoxycholic acid for gallstone dissolution."
2.	Body Weight (Weight, Body) 12/01/2013 - "During the first 6 d after weaning, piglets were intragastrically infused once daily with either deionized water (control), chenodeoxycholic acid (CDC; 60 mg/kg body weight), or β-sitoesterol (BSE; 100 mg/kg body weight). " 08/01/1986 - "It was shown that feeding chenodeoxycholic acid (CDCA) for 24 days in dosages of 15, 30, and 60 mg/kg of body weight, all depressed PD equally but significantly (P less than 0.05) in three groups of dogs compared with a control group. " 06/01/1983 - "Chenodeoxycholic acid was given to 97 patients in a dosage of 15 mg/kg of body weight per day for a period of two years. " 03/17/1980 - "This study demonstrates that medical dissolution of gallstones with chenodeoxycholic acid should be performed in patients with radiolucent stones of less than 2 cm in diameter and with a dose above 13 mg CDC/kg body weight/day. " 03/01/2009 - "We found that wild-type but not Fxr knockout mice on diets enriched with chenodeoxycholic acid (CDCA) increase their liver/body weight ratios by 50% due to hepatocellular hypertrophy. "
3.	Diarrhea 11/01/2020 - "Chenodeoxycholic acid is an effective treatment for symptomatic relief of diarrhea in patients with CTX." 03/01/2021 - "Chenodeoxycholic acid (CDCA) treatment was introduced with remission of diarrhea. " 08/01/1979 - "Orally administered chenodeoxycholic acid (300 mg/kg) produced diarrhea and accumulation of gastro-intestinal fluid in rats. " 09/01/1976 - "Chenodeoxycholic acid also was increased from 3.2 +/- 0.7 to 8.7 +/- 3.2% in diarrhea but the difference was not significant statistically. " 11/01/2020 - "In the current study, we evaluated the characteristics of the diarrhea and its response to chenodeoxycholic acid (CDCA) therapy in a cohort of Dutch CTX patients. "
4.	Liver Diseases (Liver Disease) 03/01/1990 - "An ultrastructural study of patients with and without overt liver disease and the effect of chenodeoxycholic acid treatment." 05/01/2002 - "Ursodeoxycholate (the beta- epimer of chenodeoxycholate) is approved for the treatment of chronic cholestatic liver disease. " 05/01/2000 - "Hence, less severe liver disease, associated with lower histological grades and biochemistries, as well as increased levels of chenodeoxycholic acid, induces an expanded apoptotic response. " 01/01/1991 - "The liver disease improves dramatically on treatment with chenodeoxycholic acid. " 03/01/1990 - "Group 2 consisted of four patients with a history of liver disease and liver histopathology; three patients were observed before and after 1 yr of chenodeoxycholic acid treatment. "
5.	Shock 01/01/1990 - "Extracorporeal shock-wave lithotripsy combined with adjuvant litholytic therapy (ursodeoxycholic acid and chenodeoxycholic acid) is a relatively safe and effective noninvasive therapy for selected patients with symptomatic radiolucent gallbladder stones. " 12/30/1991 - "The new nonsurgical methods of treating gallstone disease in gallbladder rely on fragmentation with extracorporeal shock wave lithotripsy (ESWL) and on dissolution of stones with ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA). " 12/01/1991 - "A prospective, double-blind, randomized, single-center study was conducted to compare ursodeoxycholic acid alone with the combination of ursodeoxycholic acid and chenodeoxycholic acid for dissolution therapy of gallstone fragments after shock wave lithotripsy. " 03/01/1995 - "To determine the effect of chenodiol and ursodiol pre-treatment prior to shock wave lithotripsy of gallstones, two groups of 50 gallbladder stones (n = 100), obtained at cholecystectomy, were matched according to their size, shape and weight. " 03/01/1989 - "Twenty-one patients with symptomatic gallstones were studied before and after shock-wave lithotripsy, 12 with and 9 without concomitant litholytic therapy (combination of ursodeoxycholic acid and chenodeoxycholic acid). "

Related Drugs and Biologics

1.	Ursodeoxycholic Acid (Urso)
2.	Cholesterol
3.	Bile Acids and Salts (Bile Acids)
4.	Cholic Acid
5.	hyodeoxycholic acid
6.	Insulin (Novolin)
7.	Acids
8.	Capsules (Microcapsules)
9.	Magnesium
10.	Phenobarbital (Luminal)

Related Therapies and Procedures

1.	Therapeutics
2.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
3.	Oral Administration
4.	Liver Transplantation
5.	Withholding Treatment