Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy)

A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)
Also Known As:
Peroneal Muscular Atrophy; Roussy Levy Syndrome; Syndrome, Roussy-Levy; Charcot-Marie Disease; Charcot-Marie-Tooth Disease, Type I; Charcot-Marie-Tooth Disease, Type II; Charcot-Marie-Tooth Disease, Type Ia; Charcot-Marie-Tooth Disease, Type Ib; HMN Distal Type I; HMSN I; HMSN II; Hereditary Areflexic Dystasia; Hereditary Type I Motor and Sensory Neuropathy; Neuropathy, Type I Hereditary Motor and Sensory; Neuropathy, Type II Hereditary Motor and Sensory; Roussy Levy Hereditary Areflexic Dystasia; Roussy-Levy Disease; Areflexic Dystasia, Hereditary; Areflexic Dystasias, Hereditary; Atrophies, Peroneal Muscular; Atrophy, Peroneal Muscular; Charcot Marie Disease; Charcot Marie Tooth Disease; Charcot Marie Tooth Disease, Type I; Charcot Marie Tooth Disease, Type II; Charcot Marie Tooth Disease, Type Ia; Charcot Marie Tooth Disease, Type Ib; Dystasia, Hereditary Areflexic; Dystasias, Hereditary Areflexic; HMSN IIs; HMSN Is; HMSN Type IIs; HMSN Type Is; Hereditary Areflexic Dystasias; Hereditary Motor and Sensory Neuropathy Type II; Is, HMSN; Muscular Atrophies, Peroneal; Peroneal Muscular Atrophies; Roussy Levy Disease; Type IIs, HMSN; Atrophy, Muscular, Peroneal; HMSN Type I; HMSN Type II; Hereditary Motor and Sensory-Neuropathy Type II; Hereditary Motor, and Sensory Neuropathy Type I; Muscular Atrophy, Peroneal; Roussy-Levy Syndrome
Networked: 546 relevant articles (7 outcomes, 38 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Myotonic Dystrophy (Dystrophia Myotonica)
2. Spinal Muscular Atrophy (Progressive Muscular Atrophy)
3. Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
4. Friedreich Ataxia (Friedreich's Ataxia)
5. Neuromuscular Diseases (Neuromuscular Disease)


1. Scherer, Steven S: 10 articles (08/2015 - 10/2002)
2. Timmerman, Vincent: 10 articles (08/2012 - 03/2002)
3. De Jonghe, Peter: 9 articles (05/2015 - 03/2002)
4. Reilly, Mary M: 9 articles (12/2014 - 11/2004)
5. Xia, Kun: 8 articles (02/2014 - 10/2002)
6. Lupski, James R: 8 articles (05/2012 - 02/2002)
7. Suter, Ueli: 7 articles (03/2014 - 12/2003)
8. Hayasaka, Kiyoshi: 7 articles (05/2011 - 01/2003)
9. Shy, Michael E: 6 articles (10/2015 - 10/2002)
10. Takashima, Hiroshi: 6 articles (04/2013 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Charcot-Marie-Tooth Disease:
1. tebufenozide (Mimic)IBA
2. TeaIBA
3. Prednisolone (Predate)FDA LinkGeneric
4. CurcuminIBA
5. pioglitazone (Actos)FDA Link
6. resveratrolIBA
7. gallocatechol (epigallocatechin)IBA
8. modafinil (armodafinil)FDA Link
9. connexin 32IBA
10. Dynamin IIIBA

Therapies and Procedures

1. Resistance Training
2. Orthotic Devices (Orthosis)
3. Osteotomy
4. Arthrodesis
5. Denervation