Chagas Cardiomyopathy

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49 relevant articles (3 outcomes, 5 trials/studies) found for this Disease

Description: A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.

Also Known As:

Chagas' Cardiomyopathy; Cardiomyopathy, Chagas'; Cardiovascular Trypanosomiasis; Cardiomyopathy, Chagas; Myocarditis, Chagas; Trypanosomiasis, Cardiovascular

Relationship Network

Disease Context: Research Results

Parasitic Diseases: 526

Protozoan Infections: 112

Sarcomastigophora Infections

Mastigophora Infections

Trypanosomiasis: 513

Chagas Disease: 1783

Chagas Cardiomyopathy: 49

Cardiovascular Diseases: 18449

Heart Diseases: 12331

Cardiomyopathies: 6552

Chagas Cardiomyopathy: 49

Related Diseases

1.	Ventricular Premature Complexes (Premature Ventricular Contraction)
2.	Heart Failure
3.	Tachycardia (Tachyarrhythmias)
4.	Trypanosomiasis
5.	Ventricular Tachycardia
18 Diseases and 18 more articles analyzed in the Research Interface, order at left...

Experts

1.	Morillo, Carlos A: 2 articles (07/2008 - 01/2006)
2.	Connolly, Stuart J: 1 article (07/2008)
3.	Sosa-Estani, Sergio: 1 article (07/2008)
4.	Rassi, Anis: 1 article (07/2008)
5.	Avezum, Alvaro: 1 article (07/2008)
6.	Marin-Neto, Jose Antonio: 1 article (07/2008)
7.	Rosas, Fernando: 1 article (07/2008)
8.	Yusuf, Salim: 1 article (07/2008)
9.	BENEFIT Investigators: 1 article (07/2008)
10.	Barojas, Marcos M: 1 article (05/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chagas Cardiomyopathy:

1.	HLA Antigens (Human Leukocyte Antigens)IBA 03/01/1988 - "HLA antigens in patients with Chagas cardiomyopathy: evidence favoring genetic protection against this disease]" 06/01/1991 - "HLA antigens in Chagas cardiomyopathy: new evidence based on a case-control study]" Get all the results and reference details, order at left...
2.	Digoxin (Digitek)FDA LinkGeneric 01/01/1978 - "After the application of oral digoxin, no significant increase of ventricular extrasystoles following exercise has been observed and the working capacity has improved in the majority of the studied cases with Chagas' cardiomyopathy." 08/01/2008 - "CONCLUSION: Lack of B-blocking agent use, serum sodium levels, left ventricular ejection fraction, digoxin treatment and New York Heart Association Class IV are independent predictors of all-cause mortality for patients with chronic heart failure secondary to Chagas' cardiomyopathy in the current era of heart failure therapy." Get all the results and reference details, order at left...
3.	AutoantibodiesIBA 01/01/1996 - "Organ-specific circulating heart autoantibodies in Chagas' cardiomyopathy: exploratory study." 01/01/2001 - "Autoantibodies in Chagas' cardiomyopathy and arrhythmias." 06/01/2005 - "Autoantibodies in vitro modulating the M2 acetylcholine receptor (M2ACh-R) were observed in patients with idiopathic dilated cardiomyopathy (IDC) or Chagas' cardiomyopathy (ChC)" Get all the results and reference details, order at left...
4.	Adrenergic Receptors (Adrenergic Receptor)IBA 01/01/2006 - "The aim of this study is to evaluate the effects of the selective beta-adrenergic receptor blocker Bisoprolol on cardiovascular mortality, hospital readmission due to progressive heart failure and functional status in patients with heart failure secondary to Chagas' cardiomyopathy" 11/01/1993 - "In an effort to correlate biochemical characteristics of the beta-adrenergic receptor complex with myocardial function, mouse myocardial GTP-binding proteins, specifically substrates for pertussis toxin (PT), were analysed with regard to the influence of infection with Trypanosoma cruzi, the causative agent of Chagas' cardiomyopathy" Get all the results and reference details, order at left...
5.	Bisoprolol (Concor)FDA LinkGeneric 01/01/2006 - "CHARITY: Chagas cardiomyopathy bisoprolol intervention study: a randomized double-blind placebo force-titration controlled study with Bisoprolol in patients with chronic heart failure secondary to Chagas cardiomyopathy [NCT00323973]." 01/01/2006 - "The aim of this study is to evaluate the effects of the selective beta-adrenergic receptor blocker Bisoprolol on cardiovascular mortality, hospital readmission due to progressive heart failure and functional status in patients with heart failure secondary to Chagas' cardiomyopathy" Get all the results and reference details, order at left...
6.	carvedilol (Coreg)FDA LinkGeneric 04/01/2007 - "A randomized trial of carvedilol after renin-angiotensin system inhibition in chronic Chagas cardiomyopathy." 04/01/2007 - "CONCLUSIONS: In patients with chronic Chagas cardiomyopathy, optimization of treatment with enalapril and spironolactone and subsequent addition of carvedilol were safe and associated with benefits in cardiac function and clinical status" Get all the results and reference details, order at left...
7.	benzonidazole (benznidazole)IBA 07/01/2008 - "Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT)." Get all the results and reference details, order at left...
8.	Spironolactone (Aldactone)FDA LinkGeneric 09/01/2006 - "CONCLUSION: Spironolactone attenuated the myocardial remodelling in Chagas cardiomyopathy, reduced mortality during the chronic phase and reduced inflammatory infiltration." 09/01/2006 - "OBJECTIVE: To evaluate the role of spironolactone in myocardial remodelling in a Chagas cardiomyopathy model" 04/01/2007 - "CONCLUSIONS: In patients with chronic Chagas cardiomyopathy, optimization of treatment with enalapril and spironolactone and subsequent addition of carvedilol were safe and associated with benefits in cardiac function and clinical status" Get all the results and reference details, order at left...
9.	AntibodiesIBA 04/01/1998 - "Our results support the notion that antibodies against sulfatide may play a role in the pathogenesis of Chagas' cardiomyopathy and other forms of heart disease and should be further studied in an effort to determine their potential role in these processes." 05/01/1996 - "Antiadrenergic and muscarinic receptor antibodies in Chagas' cardiomyopathy." Get all the results and reference details, order at left...
10.	Amiodarone (Amiodarona)FDA LinkGeneric 07/01/1983 - "Effects of amiodarone on the elastic properties of the left ventricle in chronic Chagas' cardiomyopathy]" 06/01/1990 - "Empiric therapy with amiodarone in patients with chronic Chagas cardiomyopathy and sustained ventricular tachycardia]" Get all the results and reference details, order at left...
45 Drugs and Important Bio-Agents and 40 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Heart Transplantation (Grafting, Heart) 09/01/1987 - "4) Although additional care is necessary and specific complications are expected, heart transplantation can be done with good results in patients with Chagas' cardiomyopathy." 06/01/2008 - "Heart transplantation is a therapeutic option for patients with end-stage Chagas' cardiomyopathy" 09/01/2006 - "We discuss the clinical features of Chagas' cardiomyopathy and available treatments including cardiac transplantation." 09/01/2006 - "We report a case of Chagas' cardiomyopathy confirmed in a patient after heart transplantation" 09/01/2006 - "Confirmation of Chagas' cardiomyopathy following heart transplantation." Get all the results and reference details, order at left...
2.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 07/01/2008 - "AIM: The purpose of this study was to investigate the modes of initiation of malignant ventricular tachyarrhythmias in patients with Chagas' cardiomyopathy (ChC) with an implantable cardioverter-defibrillator (ICD) through the analysis of stored intracardiac electrograms" 05/01/2008 - "CONCLUSIONS: In implantable cardioverter defibrillator recipients with Chagas cardiomyopathy, spontaneous monomorphic ventricular tachycardia episodes are typically initiated by late-coupled premature ventricular complexes, which often show a short-long-short sequence." 01/01/1999 - "Time to first shock in implantable cardioverter defibrillator (ICD) patients with Chagas cardiomyopathy." Get all the results and reference details, order at left...
3.	Defibrillators (Defibrillator) 05/01/2008 - "METHODS: We studied 222 stored electrograms in 14 patients with Chagas cardiomyopathy and spontaneous monomorphic ventricular tachycardia treated with a cardioverter defibrillator" Get all the results and reference details, order at left...
4.	Sympathectomy (Sympathectomies) 11/01/2000 - "Relation of regional sympathetic denervation and myocardial perfusion disturbance to wall motion impairment in Chagas' cardiomyopathy." Get all the results and reference details, order at left...
4 Therapies and Procedures and 10 more articles analyzed in the Research Interface, order at left...

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