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Cerebroside-Sulfatase (Arylsulfatase A)

An enzyme that catalyzes the hydrolysis of cerebroside 3-sulfate (sulfatide) to yield a cerebroside and inorganic sulfate. A marked deficiency of arylsulfatase A, which is considered the heat-labile component of cerebroside sulfatase, has been demonstrated in all forms of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.8.
Also Known As:
Arylsulfatase A; Cerebroside Sulfatase; Sulfatase, Sulfatidate; Sulfatidate Sulfatase; Cerebroside-3-sulfate 3-sulfohydrolase
Networked: 435 relevant articles (9 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Gieselmann, Volkmar: 33 articles (07/2022 - 01/2003)
2. Matzner, Ulrich: 16 articles (01/2021 - 01/2005)
3. Gieselmann, V: 15 articles (02/2010 - 03/2000)
4. Krägeloh-Mann, Ingeborg: 8 articles (03/2022 - 11/2017)
5. Martino, Sabata: 8 articles (01/2021 - 05/2005)
6. Eckhardt, Matthias: 8 articles (09/2015 - 06/2006)
7. Fogh, Jens: 7 articles (06/2012 - 05/2005)
8. Lüllmann-Rauch, R: 7 articles (08/2006 - 05/2001)
9. Böhringer, Judith: 6 articles (03/2022 - 11/2017)
10. Biffi, Alessandra: 6 articles (01/2021 - 09/2006)

Related Diseases

1. Metachromatic Leukodystrophy (Sulfatide Lipidosis)
2. Neoplasms (Cancer)
3. Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy)
01/01/1981 - "An improved method has been developed for the detection of heterozygotes for feline and human mucopolysaccharidosis VI. Arylsulfatase-A and -B activities were assayed in leukocyte extracts following separation of the enzymes by batch chromatography on DEAE cellulose. "
10/31/1991 - "Study of the molecular forms of arylsulfatases confirmed the complete deficiency of arylsulfatase A and arylsulfatase B activities in metachromatic leukodystrophy and mucopolysaccharidosis type VI lymphoid cells, respectively. "
10/31/1991 - "The enzyme activity of arylsulfatase A and arylsulfatase B was studied in Epstein-Barr virus-transformed lymphoid cell lines established from control individuals and patients affected with metachromatic leukodystrophy, mucopolysaccharidosis type VI (or Maroteaux-Lamy syndrome) and multiple sulfatase deficiency. "
03/01/2016 - "Mutation of arylsulfatase A, arylsulfatase B, ceroid-lipofuscinosis neuronal 3, mucolipin, or Niemann-Pick disease type C1 respectively underlie several diseases of apparently insufficient autophagic flux that affect the eye, including: metachromatic leukodystrophy, mucopolysaccharidosis type VI, juvenile-onset Batten disease, mucolipidosis IV, and Niemann-Pick type C associated with myelin sheath destruction of corneal sensory and ciliary nerves and of the optic nerve; corneal clouding, ocular hypertension, glaucoma and optic nerve atrophy; accumulation of 'ceroid-lipofuscin' in surface conjunctival cells, and in ganglion and neuronal cells; decreased visual acuity and retinal dystrophy; and neurodegeneration. "
4. Nervous System Diseases (Neurological Disorders)
5. Memory Disorders (Memory Loss)

Related Drugs and Biologics

1. Enzymes
2. Sulfoglycosphingolipids (Sulfatides)
3. Lysergic Acid Diethylamide (LSD)
4. DEAE-Cellulose
5. Complementary DNA (cDNA)
6. N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)
7. Arylsulfatases
8. beta-Galactosidase (Lactaid)
9. Hydrolases
10. Interleukin-8 (Interleukin 8)

Related Therapies and Procedures

1. Enzyme Replacement Therapy
2. Therapeutics
3. Cell- and Tissue-Based Therapy (Cell Therapy)
4. Hematopoietic Stem Cell Transplantation
5. Intravenous Injections