Cerebral Palsy (Spastic Diplegia)

A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
Also Known As:
Spastic Diplegia; Cerebral Palsy, Congenital; Cerebral Palsy, Spastic; Athetoid Cerebral Palsy; Dyskinetic Cerebral Palsy; CP (Cerebral Palsy); Cerebral Palsy, Athetoid; Cerebral Palsy, Atonic; Cerebral Palsy, Diplegic, Infantile; Cerebral Palsy, Dyskinetic; Cerebral Palsy, Dystonic-Rigid; Cerebral Palsy, Hypotonic; Cerebral Palsy, Mixed; Cerebral Palsy, Monoplegic, Infantile; Cerebral Palsy, Quadriplegic, Infantile; Cerebral Palsy, Rolandic Type; Congenital Cerebral Palsy; Diplegia, Spastic; Infantile Cerebral Palsy, Diplegic; Infantile Cerebral Palsy, Monoplegic; Infantile Cerebral Palsy, Quadriplegic; Little's Disease; Monoplegic Infantile Cerebral Palsy; Rolandic Type Cerebral Palsy; Atonic Cerebral Palsy; Cerebral Palsies, Athetoid; Cerebral Palsies, Dyskinetic; Cerebral Palsies, Dystonic-Rigid; Cerebral Palsies, Monoplegic; Cerebral Palsy, Dystonic Rigid; Cerebral Palsy, Monoplegic; Diplegias, Spastic; Dystonic-Rigid Cerebral Palsies; Dystonic-Rigid Cerebral Palsy; Hypotonic Cerebral Palsies; Hypotonic Cerebral Palsy; Mixed Cerebral Palsies; Mixed Cerebral Palsy; Monoplegic Cerebral Palsies; Spastic Cerebral Palsies; Spastic Cerebral Palsy; Spastic Diplegias; Diplegic Infantile Cerebral Palsy; Little Disease; Monoplegic Cerebral Palsy; Quadriplegic Infantile Cerebral Palsy
Networked: 3299 relevant articles (226 outcomes, 590 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Muscle Spasticity (Spastic)
2. Sialorrhea
3. Congenital Abnormalities (Deformity)
4. Dystonia (Limb Dystonia)
5. Pain (Aches)


1. Miller, Freeman: 32 articles (04/2012 - 02/2002)
2. Becher, Jules G: 23 articles (07/2015 - 05/2005)
3. Graham, H Kerr: 22 articles (04/2015 - 12/2002)
4. Park, Eun Sook: 16 articles (01/2015 - 04/2004)
5. Doyle, Lex W: 16 articles (12/2014 - 11/2003)
6. Dabney, Kirk W: 16 articles (04/2012 - 02/2002)
7. Boyd, Roslyn N: 14 articles (11/2015 - 01/2003)
8. Rouse, Dwight J: 14 articles (11/2015 - 09/2007)
9. Molenaers, Guy: 14 articles (06/2015 - 01/2006)
10. Desloovere, Kaat: 13 articles (06/2015 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cerebral Palsy:
1. Botulinum Toxins (Botulinum Toxin)IBA
2. Type A Botulinum Toxins (Botulinum A Toxin)FDA Link
3. BaclofenFDA LinkGeneric
4. Magnesium Sulfate (Sulfate, Magnesium)FDA LinkGeneric
5. pamidronate (APD)FDA LinkGeneric
6. Trihexyphenidyl (Artane)FDA LinkGeneric
7. Glycopyrrolate (Glycopyrronium Bromide)FDA LinkGeneric
8. OxygenIBA
9. abobotulinumtoxinAFDA Link
10. Growth Hormone (Somatotropin)IBA

Therapies and Procedures

1. Injections
2. Rhizotomy
3. Orthotic Devices (Orthosis)
4. Osteotomy
5. Resistance Training