Brain Hypoxia (Cerebral Hypoxia)

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592 relevant articles (27 outcomes, 52 trials/studies) found for this Disease

Description: A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.

Also Known As:

Cerebral Hypoxia; Anoxic Brain Damage; Hypoxia, Brain; Anoxia, Cerebral; Brain Anoxia; Hypoxia, Cerebral; Hypoxic Brain Damage; Anoxic Encephalopathies; Brain Damage, Anoxic; Brain Damage, Hypoxic; Damage, Anoxic Brain; Damage, Hypoxic Brain; Encephalopathies, Anoxic; Encephalopathies, Hypoxic; Encephalopathy, Anoxic; Hypoxic Encephalopathies; Anoxia, Brain; Anoxic Encephalopathy; Cerebral Anoxia; Encephalopathy, Hypoxic; Hypoxic Encephalopathy

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3420

Central Nervous System Diseases: 931

Brain Diseases: 1120

Brain Hypoxia: 592

Brain Hypoxia-Ischemia: 367

Related Diseases

1.	Anoxia (Hypoxia)
2.	Ischemia
3.	Hypothermia
4.	Brain Injuries (Brain Injury)
5.	Heart Arrest (Cardiac Arrest)

Experts

1.	Roca-Tey, L: 1 article (07/2008)
2.	Ramos-Brunet, A: 1 article (07/2008)
3.	Salazar-Tortolero, G: 1 article (07/2008)
4.	Talamantes-Escriba, F: 1 article (07/2008)
5.	Weiser-Blanch, R: 1 article (07/2008)
6.	Talamantes-Escribá, F: 1 article (07/2008)
7.	Marín-Caballos, A J: 1 article (03/2008)
8.	Leal-Noval, S R: 1 article (03/2008)
9.	Murillo-Cabezas, F: 1 article (03/2008)
10.	Muñoz-Sánchez, M A: 1 article (03/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Brain Hypoxia:

1.	CalciumIBA 09/01/2004 - "Glial perspectives of metabolic states during cerebral hypoxia--calcium regulation and metabolic energy." 02/01/1996 - "Calcium entry blockers appear promising as a treatment for postischemic-anoxic encephalopathy" 12/01/1992 - "To investigate mechanisms of cerebral anoxia tolerance, cerebrocortical intracellular calcium ([Ca2+]i) and pH (pHi) regulation were compared in turtles (Trachemys scripta) and laboratory rats" 12/01/1992 - "Cerebral anoxia tolerance in turtles: regulation of intracellular calcium and pH." 02/21/1992 - "We tested the hypothesis that suppression of inward calcium current in presynaptic terminals is the cause of failure of synaptic transmission early during cerebral hypoxia" Order ALL the reference details at left...
2.	FlunarizineIBA 05/01/1985 - "Flunarizine has been tested both against brain hypoxia and SD" 04/01/1982 - "The protective effect of flunarizine against cerebral hypoxia-anoxia was investigated with various experimental models in mice and rats" 04/01/1982 - "Protective effect of flunarizine against cerebral hypoxia-anoxia in mice and rats." 04/01/1982 - "The oral treatment of animals with flunarizine resulted in a consistent and long-lasting-protection against cerebral hypoxia-anoxia in all the models examined: Cytotoxic anoxia by KCN injection, hypercapnic anoxia induced by stopping artificial respiration, hypobaric hypoxia and normobaric hypoxia" 11/01/1993 - "The depolarization-induced increase in intrasynaptosomal free cytosolic calcium concentration is also inhibited by flunarizine, a calcium antagonist that has protective effects in animal models of cerebral anoxia and ischemia" Order ALL the reference details at left...
3.	Nicardipine (Dagan)FDA LinkGeneric 10/01/1989 - "To study the protective effects of nicardipine on brain hypoxia, the same techniques were also used after the inhalation" 01/01/1986 - "Nicardipine: protection against brain hypoxia." Order ALL the reference details at left...
4.	Thiopental (Pentothal)FDA Link 01/01/1978 - "The results shows that the prevention, by thiopental, of the clinical and histological lesion secondary to cerebral anoxia is effective when this drug is administered before the 15th minute" 06/01/1982 - "This favourable outcome is thought to be due to the administration of thiopentone for the amelioration of hypoxic brain damage in dosages commonly employed in anaesthesia." 03/01/1979 - "To corroborate thiopental protection from cerebral anoxia after cardiopulmonary arrest, 23 sedated, curarized, adult dogs were asphyxiated by plugging the endotracheal tube" 01/01/1987 - "High-dose thiopental was administered in 8 children with uncontrollable seizures or hypoxic encephalopathy (group A) and 7 full-term neonates with neonatal asphyxia (group B)" 10/01/1980 - "We believe that etomidate like thiopentone has brain protective properties in patients with cerebral hypoxia and must therefore be considered as an important therapeutic agent in such patients." Order ALL the reference details at left...
5.	OxygenIBA 01/01/1996 - "Although the key to protection against cerebral hypoxia cannot be established, it is possible that an increase in the usually short period of acclimatization could minimize brain damage in those low-landers who attempt the highest summits without supplementary oxygen." 10/01/2008 - "OBJECTIVE: This study aimed to prepare a hypoxic brain damage model in the neonatal rat using a new approach, 0% oxygen exposure, and to explore the reliability and advantages of the new model" 01/01/2002 - "The aim of our study was to perform and in-depth analysis of several episodes of regional brain hypoxia detected by monitoring brain partial pressure of oxygen (PtiO2) in which simultaneous measurements of cerebral oxygen extraction fraction (O2EF) suggested a normally perfused or even a hyperemic brain" 11/01/1971 - "Oxygen respiration under increased pressure as a method for the control of cerebral hypoxia (experimental study)]" 10/01/2008 - "CONCLUSIONS: A hypoxic brain damage model of neonatal rat was successfully prepared using 7 minutes 0% oxygen exposure" Order ALL the reference details at left...
6.	Adenosine Triphosphate (ATP)IBA 08/01/2004 - "These studies demonstrate that K(ATP) channels are an ubiquituous feature of mammalian neurons and may, indeed, play a protective role in brain hypoxia." 10/01/2004 - "ATP/PCr levels were the same in groups 3 and 4 denoting the same degree of cerebral hypoxia in all hypoxic animals" 12/01/2001 - "During recovery from hypoxia, brain PCr and ATP concentrations returned to baseline in wild-types but were 20% higher than baseline in the mutants" 12/01/2001 - "During graded hypoxia, cerebral tissue ATP decreased from 4.80 +/- 0.58 (normoxic) to 1.03 +/- 0.38 (ranging from 0.61-1.63) micromol/g brain (p < 0.05) and PCr decreased from 3.94 +/- 0.75 (normoxic) to 0.99 +/- 0.27 (ranging from 0.50 to 1.31) micromol/g brain (p < 0.05)" 10/01/2001 - "The few species that survive brain anoxia for days or months, such as the freshwater turtle Trachemys scripta, avoid anoxic depolarization and maintain brain ATP levels through a coordinated downregulation of brain energy demand processes" Order ALL the reference details at left...
7.	Diazepam (Valium)FDA LinkGeneric 12/01/1975 - "Polygraphic recordings of EEG, EMG, EKG and respiration were made on three patients with histologically verified subacute spongiform encephalopathy and one patient with anoxic encephalopathy both before and after intravenous diazepam" 08/01/1987 - "Diazemuls infusion was effective in one patient with complex partial status epilepticus; in another patient with convulsion secondary to a brain stem infarct, the convulsions were abolished; while only reduced jerking was achieved in the third patient suffering from myoclonic jerks caused by anoxic brain damage" 12/01/2004 - "This study describes the case of a 24-year old male who developed delayed post-hypoxic encephalopathy following an unintentional methadone and diazepam overdose and who demonstrated cognitive and neurobehavioural improvements during treatment with amantadine HCl hydrochloride in a single-case, open-label design" Order ALL the reference details at left...
8.	Alprostadil (Muse)FDA LinkGeneric 01/01/2000 - "Unexplained death occurred between two and five days after the birth: one infant with a large patent foramen ovale did not receive prostaglandin E1, four patients died a few hours after an angiographic study or a balloon atrioseptostomy was performed in a catheterization laboratory, and one child suffered from a cerebral anoxia due to a tightened cord" 11/01/1986 - "Among the PGs tested, treatment with PGD2, PGE1 and PGI2 Na showed a consistent and dose-dependent protection against cerebral anoxia induced by all models studied: histotoxic anoxia by KCN, hypobaric hypoxia, normobaric hypoxia and decapitation-induced gasping" Order ALL the reference details at left...
9.	Tsumura-ZokumeitoIBA 06/01/1987 - "Pharmacological study of TJ-8007 (Tsumura-Zokumeito) (I): Protective effects of TJ-8007 against anoxic brain damage]" 06/01/1987 - "The protective effects of TJ-8007 (Tsumura-Zokumeito, Traditional chinese medicine) against cerebral anoxia were investigated with various experimental models in mice and rats" 04/01/1989 - "It has been demonstrated that TJ-8007 (Tsumura-Zokumeito, A traditional Chinese medicine) has a protective effect against cerebral anoxia" Order ALL the reference details at left...
10.	Local AnestheticsIBA 05/01/1989 - "Protection against cerebral hypoxia by local anesthetics: a study using brain slices." Order ALL the reference details at left...

Therapies and Procedures

1.	Resuscitation 01/01/2008 - "She regained spontaneous circulation following resuscitation, but hypoxic encephalopathy was identified" 03/01/2007 - "After initial successful resuscitation, the patient died 1 week later due to severe hypoxic brain damage" 07/01/2003 - "Six patients ultimately died, 2 from anoxic encephalopathy due to failed resuscitation and 4 from comorbid illness" 04/01/2002 - "Research since around 1970 into cardiopulmonary-cerebral resuscitation has attempted to mitigate the postischemic-anoxic encephalopathy" 11/01/1996 - "Despite immediate resuscitation efforts the patient developed severe hypoxic brain damage and died a few days later" Order ALL the reference details at left...
2.	Artificial Respiration (Mechanical Ventilation) 07/01/1996 - "MATERIALS AND METHODS: MR imaging (MRI) and H-1 MR spectroscopy (H-1 MRS) were performed on three patients with hypoxic encephalopathy, who had need temporary mechanical ventilation, and five healthy age-matched volunteers" 01/01/1983 - "The sequelae of slight hypoxic encephalopathy could account for some nervous long-term effects in men acutely poisoned by OP and surviving owing to mechanical ventilation." 04/01/1982 - "The oral treatment of animals with flunarizine resulted in a consistent and long-lasting-protection against cerebral hypoxia-anoxia in all the models examined: Cytotoxic anoxia by KCN injection, hypercapnic anoxia induced by stopping artificial respiration, hypobaric hypoxia and normobaric hypoxia" Order ALL the reference details at left...
3.	Chinese Traditional Medicine (Traditional Chinese Medicine) 06/01/1987 - "The protective effects of TJ-8007 (Tsumura-Zokumeito, Traditional chinese medicine) against cerebral anoxia were investigated with various experimental models in mice and rats" 04/01/1989 - "It has been demonstrated that TJ-8007 (Tsumura-Zokumeito, A traditional Chinese medicine) has a protective effect against cerebral anoxia" Order ALL the reference details at left...
4.	Drug Therapy (Chemotherapy) 04/01/1998 - "2) Mean hemispheric CBF measured by the Xe-CT method exceeded 25 ml/100 g per min. 3) The mean increase in hemispheric CBF 20 min after acetazolamide administration exceeded 5 ml/100 g per min. 4) An N20 peak was evident on the median nerve SEP, SCS appears to be an effective supplementary for unresponsive patients with hypoxic encephalopathy at the subacute stage, in addition to rehabilitation and drug therapy." Order ALL the reference details at left...
5.	Cardiopulmonary Bypass (Heart-Lung Bypass) 09/01/1997 - "Cerebral hypoxia during cardiopulmonary bypass: a magnetic resonance imaging study." 01/01/2003 - "Myocardial and cerebral hypoxia can be complications to cardiopulmonary bypass (CPB) surgery" 02/01/1996 - "We consider that NCPB is a useful technique for preventing cerebral hypoxia, if the decrease of SjVO2 during the early period of cardiopulmonary bypass is avoidable" 08/01/1997 - "INTRODUCTION: Cardiopulmonary bypass (CEC) in the surgical treatment of cardiac diseases may cause the appearance of neurological damage of an intensity which varies between minor neuropsychological disorders and global cerebral anoxia" 05/01/1997 - "During the past decade a new syndrome has been recognized: cerebral hypoxia secondary to cardiopulmonary bypass, resulting in impairment of cognitive memory" Order ALL the reference details at left...

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