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Galactosylgalactosylglucosylceramidase

An enzyme that catalyzes the hydrolysis of a ceramidetrihexoside to a ceramidedihexoside plus galactose.

Also Known As:

Trihexosidase, Ceramide; Ceramide Trihexosidase; D-Galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Glycoside Hydrolases: 871
      - Galactosidases: 1473
        Galactosylgalactosylglucosylceramidase: 3

Experts

1.	Kelash, Fnu: 1 article (01/2014)
2.	Kujtan, Lara: 1 article (01/2014)
3.	Mallidi, Padmaja V: 1 article (01/2014)

Related Diseases

1.

Fabry Disease (Fabry's Disease)

09/04/1970 - "Thus, periodic replacement of ceramide trihexosidase activity in the plasma of patients with Fabry's disease might lead to consistently lower amounts of substrate in the plasma and a decrease in its rate of accumulation in tissues."
01/01/1969 - "[Absent renal ceramide-trihexosidase activity in Fabry's disease]."
09/04/1970 - "Two patients with Fabry's disease were infused with normal plasma to provide active enzyme (ceramide trihexosidase) for hydrolysis of the plasma substrate, galactosylgalactosylglucosylceramide. "
01/01/2014 - "Fabry disease is an X-linked lysosomal storage disorder caused by deficient activity of a-galactosidase A (also known as ceramide trihexosidase) and resultant accumulation of globotriaosylceramide (Gb3) and related glycophospholipids. "

Related Drugs and Biologics

1.	Galactosidases
2.	Enzymes
3.	globotriaosylceramide (globotriosylceramide)