Neoplastic Cell Transformation

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54 relevant articles (0 outcomes, 7 trials/studies) found for this Disease

Description: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Also Known As:

Cell Transformation, Neoplastic; Transformation, Neoplastic Cell; Cell Neoplastic Transformation; Cell Neoplastic Transformations; Cell Transformations, Neoplastic; Neoplastic Cell Transformations; Neoplastic Transformations, Cell; Transformation, Cell Neoplastic; Transformations, Cell Neoplastic; Transformations, Neoplastic Cell; Neoplastic Transformation, Cell

Disease Context: Research Results

Neoplasms: 386513

Neoplastic Processes: 162

Neoplastic Cell Transformation: 54

Blast Crisis: 941

Viral Cell Transformation: 2

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2205

Neoplastic Processes: 162

Neoplastic Cell Transformation: 54

Blast Crisis: 941

Viral Cell Transformation: 2

Related Diseases

1.	Neoplasms (Cancer)
2.	DNA Damage
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
4.	Neoplasm Metastasis (Metastasis)
5.	Aneuploidy (Aneuploid)
8 Diseases and 16 more articles analyzed in the Research Interface, order at left...

Experts

1.	Bode, Ann M: 4 articles (11/2007 - 06/2004)
2.	Dong, Zigang: 4 articles (11/2007 - 06/2004)
3.	Cho, Yong-Yeon: 3 articles (11/2007 - 06/2004)
4.	Lee, Ki Won: 2 articles (11/2007 - 09/2007)
5.	Kang, Nam Joo: 2 articles (11/2007 - 09/2007)
6.	Rogozin, Evgeny A: 2 articles (11/2007 - 09/2007)
7.	Lee, Hyong Joo: 2 articles (11/2007 - 09/2007)
8.	Choi, Hong Seok: 2 articles (07/2005 - 06/2004)
9.	Choi, Bu Young: 2 articles (07/2005 - 06/2004)
10.	Mizuno, Hideya: 2 articles (07/2005 - 06/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neoplastic Cell Transformation:

1.	DNA (Deoxyribonucleic Acid)IBA 04/01/1989 - "SCE formation is a sensitive indicator of carcinogen-DNA interaction that correlates with the induction of mutation and neoplastic cell transformation" 01/01/1989 - "The high RBE of high-LET radiation for cell killing and neoplastic cell transformation is most likely related to its effectiveness in producing DNA double strand breaks in mammalian cells" 11/01/1985 - "The induction of neoplastic cell transformation is closely associated with DNA alterations which occur shortly after carcinogen exposure" 05/01/1973 - "Change in cytoplasmic DNA during neoplastic cell transformation]" 08/01/2007 - "Despite the undoubtable role of genetic mechanisms in triggering neoplastic cell transformation, epigenetic modifications (i.e., heritable changes of gene expression that do not derive from alterations of the nucleotide sequence of DNA) are rapidly emerging as frequent alterations that often occur in the early phases of tumorigenesis and that play an important role in tumor development and progression" Get all the results and reference details, order at left...
2.	Epidermal Growth Factor (EGF)IBA 09/01/1999 - "We have used JB6 cells to study the role of PI-3 K in 12-O-tetradecanoylphorbol-13-acetate (TPA)- or EGF-induced AP-1 activation and neoplastic cell transformation" 08/01/2008 - "Here we report that fucoidan from Laminaria cichorioides inhibited the epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic cell transformation, but had less cytotoxic effects on JB6 mouse epidermal cells" 07/01/2005 - "These results indicate that the phosphorylation of histone H3 at Ser10 is an essential regulatory mechanism for EGF-induced neoplastic cell transformation." 05/28/1998 - "AP-1 transactivation appears to be required for mouse JB6 cell neoplastic transformation induced by the tumor promoter TPA or epidermal growth factor (EGF)" Get all the results and reference details, order at left...
3.	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 09/01/1999 - "We have used JB6 cells to study the role of PI-3 K in 12-O-tetradecanoylphorbol-13-acetate (TPA)- or EGF-induced AP-1 activation and neoplastic cell transformation" 05/28/1998 - "AP-1 transactivation appears to be required for mouse JB6 cell neoplastic transformation induced by the tumor promoter TPA or epidermal growth factor (EGF)" 11/09/2007 - "Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway." Get all the results and reference details, order at left...
4.	CarcinogensIBA 11/01/1985 - "Although a correlation between the persistence of SCE and the induction of transformation was not observed for all carcinogens, this study illustrates that DNA damage generating SCE can persist over several replicative cycles, thus raising the possibility that lasting DNA alterations are important for the induction of neoplastic cell transformation." 08/01/1990 - "Neoplastic cell transformation induced by estrogens and some other carcinogens such as benzene appears to involve the induction of mitotic aneuploidy rather than DNA damage and point mutations" 01/01/1991 - "The observation that carotenoids can inhibit neoplastic cell transformation when administered not only together with but also after the application of chemical or physical carcinogens might indicate a role of singlet oxygen in tumor promotion that could be independent of the direct or indirect DNA damaging properties." Get all the results and reference details, order at left...
5.	Proteins (Proteins, Gene)IBA 03/01/2001 - "In this study, we report that thyroid cell neoplastic transformation is associated with a dramatic increase in ETS transcriptional activity, which is dependent on the accumulation of Ets-1, Ets-2, and other Ets-related proteins" 01/01/1997 - "Some members of the HMG protein family (i) constitute a class of important architectural proteins involved in transcriptional regulation of genes, (ii) are frequently expressed in transformed cells at levels that correlate with the degree of neoplastic cell transformation, (iii) participate in gene rearrangements, which are linked to the emergence of benign solid tumors, (iv) confer the ability to recognize DNA-cisplatin adducts selectively, and (v) provide a new delivery system for efficient gene transfer" Get all the results and reference details, order at left...
6.	fucoidanIBA 05/01/2008 - "In this study, we tested the hypothesis that fucoidan may suppress neoplastic cell transformation by inhibiting the phosphorylation of epidermal growth factor receptor (EGFR) in mouse epidermal JB6 Cl41 cells" 08/01/2008 - "Here we report that fucoidan from Laminaria cichorioides inhibited the epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic cell transformation, but had less cytotoxic effects on JB6 mouse epidermal cells" Get all the results and reference details, order at left...
7.	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 09/01/2008 - "In particular, recent studies have indicated the association between elevated NO production and neoplastic cell transformation, suggesting procarcinogenic effects of NO. To investigate the mechanism by which NO facilitates oral carcinogenesis, we tested the effects of exogenous NO on the expression of hnRNP G, a novel protein demonstrating tumor suppressive effects against oral squamous cell carcinomas" Get all the results and reference details, order at left...
8.	Estrogen ReceptorsIBA 01/01/1985 - "For example, studies using in vitro cell culture systems which contain no estrogen receptors have shown that DES can induce neoplastic cell transformation, mutagenesis, irreversible binding to DNA and protein and unscheduled DNA synthesis" Get all the results and reference details, order at left...
9.	Epidermal Growth Factor Receptor (EGF Receptor)IBA 05/01/2008 - "In this study, we tested the hypothesis that fucoidan may suppress neoplastic cell transformation by inhibiting the phosphorylation of epidermal growth factor receptor (EGFR) in mouse epidermal JB6 Cl41 cells" Get all the results and reference details, order at left...
10.	IonsIBA 01/01/1984 - "Our recent studies with super-heavy high-energy particles, e.g., 960 MeV/U U235 ions (LET = 1900 keV/micrometer), indicate that these ions with a high inactivation cross-section can cause neoplastic cell transformation" Get all the results and reference details, order at left...
74 Drugs and Important Bio-Agents and 53 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Immunotherapy 04/01/2003 - "A deeper understanding of the molecular biology of cell growth and proliferation, as well as of neoplastic cell transformation, has led to advances in several areas, including the use of hormones and antihormones as adjuvant therapy; inhibition of tumour growth and metastasis by inhibitors of matrix metalloproteases and angiogenesis, and by small molecules, such as retinoids, which interfere with progression through the cell cycle; immunotherapy with monoclonal antibodies; disruption of intracellular signal transduction with farnesyltransferase inhibitors; and, finally, gene therapy with specifically designed vaccines." 05/01/2000 - "A more profound understanding of the molecular biology of cell growth and proliferation, as well as of neoplastic cell transformation, has led to advances in several areas, including the use of somatostatin analogues and antiandrogens as adjuvant therapy; inhibition of tumour growth and metastasis by inhibitors of matrix metalloproteinases and angiogenesis, and by small molecules such as retinoids, which interfere with progression through the cell cycle; immunotherapy with monoclonal antibodies; disruption of intracellular signal transduction with farnesyltransferase inhibitors; and finally gene therapy with specifically designed vaccines." Get all the results and reference details, order at left...
2.	Heterologous Transplantation (Xenotransplantation) 12/01/1994 - "This method can be applied to archival material either as a means of confirming that the tissue taken from nude mice xenografts is predominantly human or as a vehicle for studying the mechanisms of host cell neoplastic transformation and their relevance to human malignant spread" Get all the results and reference details, order at left...
3.	Drug Therapy (Chemotherapy) 06/01/2006 - "Significant findings such as the observation that histone H3 phosphorylation (Ser10) is critical for neoplastic cell transformation suggests that histone H3 may be a crucial target for cancer chemotherapy or genetic therapy in the future." Get all the results and reference details, order at left...
3 Therapies and Procedures and 4 more articles analyzed in the Research Interface, order at left...

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