Celiac Disease (Celiac Sprue)

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2559 relevant articles (98 outcomes, 278 trials/studies) found for this Disease

Description: A malabsorption syndrome that is precipitated by the ingestion of GLUTEN-containing foods, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.

Also Known As:

Celiac Sprue; Nontropical Sprue; Gluten-Sensitive Enteropathy; Disease, Celiac; Enteropathies, Gluten; Enteropathies, Gluten-Sensitive; Enteropathy, Gluten; Enteropathy, Gluten-Sensitive; Gluten Enteropathies; Gluten Sensitive Enteropathy; Gluten-Sensitive Enteropathies; Gluten Enteropathy; Sprue, Celiac; Sprue, Nontropical

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 29

Gastrointestinal Diseases: 1159

Intestinal Diseases: 580

Malabsorption Syndromes: 406

Celiac Disease: 2559

Nutritional and Metabolic Diseases

Metabolic Diseases: 1268

Malabsorption Syndromes: 406

Celiac Disease: 2559

Related Diseases

1.	Celiac Disease (Celiac Sprue)
2.	Atrophy
3.	Dermatitis Herpetiformis (Disease, Duhring's)
4.	Diarrhea
5.	Liver Diseases (Liver Disease)

Experts

1.	Khosla, Chaitan: 13 articles (02/2008 - 01/2002)
2.	Sollid, Ludvig M: 12 articles (10/2007 - 09/2002)
3.	Koning, Frits: 11 articles (10/2008 - 06/2002)
4.	Murray, Joseph A: 10 articles (04/2008 - 10/2003)
5.	Cerf-Bensussan, Nadine: 10 articles (01/2008 - 03/2003)
6.	Cellier, Christophe: 8 articles (07/2008 - 09/2003)
7.	Green, Peter H R: 8 articles (02/2008 - 02/2003)
8.	Mäki, Markku: 8 articles (01/2008 - 03/2002)
9.	Mulder, Chris J J: 8 articles (09/2007 - 09/2002)
10.	Kaukinen, Katri: 7 articles (01/2008 - 03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Celiac Disease:

1.	Gluten (Glutens)IBA 06/28/2004 - "The treatment of celiac disease remains a lifelong gluten-free diet, which results in remission for most individuals" 11/20/2003 - "Most patients have subclinical celiac disease; a gluten-free diet is effective in most cases" 04/01/2005 - "Complete removal of gluten from the diet in a patient with celiac disease should result in symptomatic, serologic, and histologic remission" 02/28/2005 - "Treatment of the patients with celiac disease with a gluten-free diet resulted in marked improvement in T scores" 02/28/2005 - "Individuals with biopsy-proven celiac disease were treated with a gluten-free diet and followed up for improvement in bone mineral density" Order ALL the reference details at left...
2.	AntibodiesIBA 01/01/1999 - "BACKGROUND: Anti-endomysial antibodies (EmA) have been shown to have a high specificity and sensitivity in celiac disease (CD) diagnosis, and their use is considered effective in improving the diagnostic accuracy of CD screening" 05/01/2008 - "Marsh I patients showed a slight antitissue transglutaminase antibodies sensitivity improvement in cultured duodenal biopsy compared to serum in definite (22% vs. 19%) and likely gluten-sensitive enteropathy (20% vs. 14%) patients" 02/01/2000 - "OBJECTIVES: To evaluate the clinical usefulness of an enzyme-linked immunoassay for anti-transglutaminase antibodies, and to compare the results with those of AEA, the current gold standard serological test for celiac disease" 08/01/1989 - "Our results point out that antigliadin antibodies are helpful in the diagnosis and management of celiac disease" 01/01/2008 - "The objective of the study was to examine AEA and JAB antibodies and the histological picture of the duodenal mucosa in 20 children and adolescents with celiac disease aged from 2 to 18 years" Order ALL the reference details at left...
3.	Immunoglobulin A (IgA)IBA 09/01/2002 - "CONCLUSIONS: screening for celiac disease using IgA EmA assay is effective in anemic patients, including premenopausal women and patients older than 65 years, and it can be recommended in clinical practice." 01/01/1994 - "Childhood celiac disease in Estonia: efficacy of the IgA-class antigliadin antibody test in the search for new cases." 11/01/1998 - "Improved method for serological testing in celiac disease--IgA anti-endomysium antibody test: a comparison between monkey oesophagus and human umbilical cord as substrate in indirect immunofluorescence test." 10/01/2007 - "BACKGROUND: The aim of this study was to retrospectively examine how positive IgA-endomysial antibody (EMA) test results for celiac disease were being interpreted and acted on by physicians in the Calgary Health Region" 01/01/2007 - "OBJECTIVE: To study the prevalence of celiac disease among blood donor volunteers based on screening by IgA antitissue transglutaminase antibody, followed by a confirmatory small intestine biopsy" Order ALL the reference details at left...
4.	GliadinIBA 04/01/2008 - "CONCLUSIONS: Deamidated gliadin antibody is a better diagnostic test for celiac disease than the conventional gliadin antibody testing; although histopathology remains the gold standard test for diagnosis of celiac patients." 11/11/1990 - "According to these results the authors conclude that the efficacy of this test is less sensitive in the newly diagnosed celiac patients, which means that it is not suitable for screening purpose, but useful for detecting gliadin sensitivity during the diagnostic period of celiac disease (e" 07/01/2007 - "Adsorption studies with gliadin and tissue transglutaminase (tTG) were performed in celiac disease sera" 01/01/2003 - "The aim of this study was to develop a three-dimensional in vitro model to investigate the effects of gliadin on epithelial cells and broaden our understanding of the early tissue damage occurring in celiac disease" 07/01/2001 - "CONCLUSIONS: In this study gliadin was not detected in pharmaceutical products in harmful amount for celiac disease patients." Order ALL the reference details at left...
5.	Immunoglobulin G (IgG)IBA 09/01/2005 - "IgG antitissue transglutaminase was detected with both ELISA and radioligand binding assays in 40 of 73 untreated celiac disease children and in 2 of 50 controls" 01/01/2005 - "Only one patient (who was subsequently found to have celiac disease) had elevated concentrations of lavage albumin, alpha1-AT and IgG levels" 03/01/2003 - "High antigliadin IgG titers in laboratory rabbits fed a wheat-containing diet: a model for celiac disease?" 10/01/1996 - "IgG-antigliadin antibody levels, elevated in 16 patients including all five celiacs, were the best parameter for predicting celiac disease and gave no false negatives" 07/01/1996 - "In these two cases, positive only for IgG AGA, celiac sprue was associated with IgA deficiency" Order ALL the reference details at left...
6.	PeptidesIBA 03/01/2003 - "DON-modified peptides could be useful for the study and therapy of celiac sprue." 10/01/2000 - "However, further studies with optimized methodology, including various concentrations of the peptide, adjuvants, other peptides, etc., are warranted, especially because the oral mucosa provides the easiest access to an in vivo peptide challenge in celiac disease." 03/01/1959 - "Studies on appearance of serum peptides in celiac disease.]" 03/01/2007 - "Celiac disease is an inflammatory disorder in which certain peptides from wheat and related grains trigger and maintain an immune reaction in the small intestine" 09/01/2005 - "This concentration of PEP decreased the amount of intact peptides 31-49 and 56-88 crossing the intestinal biopsy specimens of celiac disease patients, but could not prevent the intestinal passage of toxic or immunostimulatory metabolites" Order ALL the reference details at left...
7.	AutoantibodiesIBA 09/01/2008 - "OBJECTIVES: To investigate if the detection of celiac disease (CD) in children was improved by using alternative conjugates for assessment of tissue transglutaminase (tTG) autoantibodies" 04/01/2007 - "The aim of this study was to determine whether these autoantibodies are involved in the pathogenesis of the mucosal lesion typical of celiac disease" 01/01/2007 - "The aim of this study was to compare the sensitivity of the serological markers in patients with non-treated celiac disease by determination of antiendomysium and anti-tissue-transglutaminase autoantibodies separately and together" 12/01/2006 - "THE AIM: of this study is to investigate the prevalence of diabetes-related autoantibodies in a group of children with celiac disease and to compare it with a control group" 09/01/2005 - "OBJECTIVE: The purpose of this study was to explore whether the presence of thyroid and endomysial autoantibodies at diagnosis of type 1 diabetes in children predicts development of thyroid and celiac disease, respectively, and whether diabetes-associated autoantibodies at diagnosis predict development of microvascular complications up to 13 years later" Order ALL the reference details at left...
8.	AntigensIBA 12/01/2000 - "Over the past few years, the availability, sensitivity and specificity of serological markers for celiac disease have improved - the most recent advancement being the description of tissue transglutaminase as the major antigen for endomysium antibody" 01/01/2008 - "Results of both tests were compatible with celiac disease.A study of human leukocyte antigen indicated a high risk phenotype (HLA, DR6/DR7; DQA 0501, 0201; DQB 0301, 0201)" 04/01/1999 - "With the aim to determine the frequency of human leukocyte antigen phenotypes of celiac disease in Turkey, thirty celiac patients fulfilling the European Society of Pediatric Gastroenterology and Nutrition criteria were included in the study" 01/01/1981 - "Use of an immunologic test in diagnosis and follow-up of celiac disease, in family screening and in the study of gastrointestinal metabolism of food antigens]" 01/01/2008 - "Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms." Order ALL the reference details at left...
9.	Immunoglobulins (Immunoglobulin)IBA 01/01/2008 - "The serum levels of immunoglobulin (Ig)A anti-tissue transglutaminase (or TG2) are the first choice in screening for celiac disease, displaying the highest levels of sensitivity (up to 98%) and specificity (around 96%)" 03/01/1999 - "BACKGROUND & AIMS: Celiac disease is characterized by disturbed jejunal crypt-villus axis biology with immunoglobulin (Ig) A deposits underlining the epithelium" 07/01/1997 - "The celiac disease patient in Group B had severe secondary immunoglobulin deficiency at entry, which explained the initial negativity" 02/13/1994 - "Distribution of immunoglobulin-containing cell subclasses in the mucosa of the small intestine in children with celiac disease]" 08/01/1990 - "Two-color immunofluorescence staining in situ demonstrated increased proportions of immunoglobulin A2 subclass-producing cells in jejunal mucosa from adult patients with untreated (47%, P less than 0.01) or treated (37%, P less than 0.05) celiac disease compared with controls (28%)" Order ALL the reference details at left...
10.	Xylose (D-Xylose)FDA Link 03/01/2007 - "This study indicates that performance of 5-g D-xylose H2BT is a better test than 5-g urinary D-xylose test in screening for intestinal malabsorption in patients with celiac disease." 03/01/2007 - "This study sought to compare D-xylose H2BT with urinary D-xylose tests in screening for intestinal malabsorption in patients with celiac disease" 03/01/2007 - "D-xylose H2BT was able to pick up 19.9% more cases of malabsorption in Indian children with celiac disease" 10/01/2001 - "The xylose-BT is as valuable a tool for the screening of celiac disease in the elderly as it is in younger patients." 10/01/2001 - "We reviewed the results of the xylose-BT in 50 patients with clinical celiac disease in whom the diagnosis was confirmed by histology" Order ALL the reference details at left...

Therapies and Procedures

1.	Aftercare (After-Treatment) 04/01/2008 - "CONCLUSIONS: Notwithstanding correlation between AAA and celiac disease, AAA assay, also after treatments, has little to offer in screening for CD compared to the well-established anti-transglutaminase assay." 12/01/2004 - "We studied gut transit and BMI in patients with celiac disease before and after treatment" 07/01/2000 - "Celiac disease patients were studied twice, at diagnosis and 1 y after treatment with a GFD" 12/01/1996 - "PURPOSE: To correlate the radiologic, histopathologic, and clinical findings in patients with celiac disease after treatment with a glutenfree diet" 10/01/1990 - "Growth acceleration and final height after treatment for delayed diagnosis of celiac disease." Order ALL the reference details at left...
2.	Jejunoileal Bypass 10/17/1997 - "The underlying causes of malabsorption were celiac disease, short bowel syndrome secondary to surgical resection, and jejuno-ileal bypass, respectively" 08/01/2003 - "Joint involvement also occurs with other gastrointestinal diseases such as Whipple's disease, celiac disease, and following intestinal bypass surgery for morbid obesity" 10/01/1977 - "Hyperoxaluria was documented in patients with pancreatic insufficiency, adult celiac disease, regional enteritis after ileectomy and partial colectomy, and jejunoileal bypass" 01/01/1992 - "2. Whipple's disease, enteric infections, intestinal bypass operations, gluten-sensitive enteropathy, pseudomembranous colitis and collagenous colitis." 09/01/1981 - "IP has been associated with various disorders: in our series two patients had scleroderma, one multiple small bowel diverticula, one systemic amyloidosis, one celiac disease, and one spinal cord injury; in only two patients was the disorder considered "idiopathic." Three patients had previously undergone a jejuno--ileal bypass for morbid obesity" Order ALL the reference details at left...
3.	Gastrectomy 01/01/1966 - "Gluten enteropathy following partial gastrectomy" 02/01/1984 - "Alcoholic cirrhosis, obstruction of the biliary tract, gastrectomy, celiac sprue and prolonged fasting may predispose to lithiasis secondary to the precipitation of sludge in a large, atonic or distended gallbladder" 10/01/1999 - "Diseases of the alimentary tract such as celiac disease, inflammatory bowel diseases, gastrectomy, cholestatic liver diseases, liver transplantation, and hepatitis C can affect bone mineralization, remodeling, or bone mass" 03/01/1975 - "The patient had gluten sensitive enteropathy, and showed increased circulating IgA levels prior to gastrectomy" 09/01/2005 - "METHODS: Ten patients were studied with chronic fat malabsorption, calcium oxalate stones, and hyperoxaluria thought to be caused by jejunoileal bypass (1) and Roux-en-Y gastric bypass surgery for obesity (4), dumping syndrome secondary to gastrectomy (2), celiac sprue (1), chronic pancreatitis (1), and ulcerative colitis in remission (1)" Order ALL the reference details at left...
4.	Gastric Bypass (Roux-en-Y Gastric Bypass) 05/01/1972 - "Endoscopic appearance of the jejunum in a patient with gluten-sensitive enteropathy and a gastrojejunostomy." 09/01/2005 - "METHODS: Ten patients were studied with chronic fat malabsorption, calcium oxalate stones, and hyperoxaluria thought to be caused by jejunoileal bypass (1) and Roux-en-Y gastric bypass surgery for obesity (4), dumping syndrome secondary to gastrectomy (2), celiac sprue (1), chronic pancreatitis (1), and ulcerative colitis in remission (1)" Order ALL the reference details at left...
5.	Surgical Instruments (Clip) 05/01/1989 - "This study was designed to determine (1) whether the site of biopsy within the proximal small bowel affects the ability to assess mucosal architecture in general, or to confirm a diagnosis of celiac sprue specifically; and (2) whether endoscopic small bowel biopsy using standard forceps can obtain adequate biopsy specimens to detect or exclude mucosal abnormalities" 09/01/2008 - "Dominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 molecule." 02/01/2003 - "Therefore we suggest that, in diagnosis and follow-up of celiac disease, mucosal specimens may be taken from the duodenum using forceps to obtain adequate material for histological interpretation." Order ALL the reference details at left...

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