|1.||Bogyo, Matthew: 24 articles (09/2015 - 05/2004)|
|2.||Kos, Janko: 24 articles (04/2015 - 01/2002)|
|3.||Turk, Boris: 21 articles (08/2015 - 01/2002)|
|4.||Shi, Guo-Ping: 17 articles (02/2014 - 01/2004)|
|5.||Joyce, Johanna A: 16 articles (12/2015 - 05/2004)|
|6.||Reinheckel, Thomas: 12 articles (01/2015 - 03/2006)|
|7.||Platt, Manu O: 11 articles (09/2015 - 08/2006)|
|8.||Lalmanach, Gilles: 11 articles (05/2015 - 01/2006)|
|9.||Brömme, Dieter: 11 articles (05/2015 - 01/2002)|
|10.||Roessner, Albert: 10 articles (01/2015 - 05/2004)|
03/01/2015 - "Activity levels of cathepsins B and L in tumor cells are a biomarker for efficacy of reovirus-mediated tumor cell killing."
01/01/2011 - "Cleared bands of cathepsin activity were identified and validated in tumor extracts and detected organ- and stage-specific differences in activity. "
04/01/2002 - "Positive results indicative of the presence of cathepsin were investigated to determine any correlation between a particular cathepsin and histologic malignancy grades, tumor cell growth, serum cathepsin activities, and clinical factors. "
01/01/2015 - "In the present study, we review the rapidly advancing field of cathepsin S in cancer therapy, highlighting the specific roles of cathepsin S in cancer. "
01/01/2015 - "Multiple studies indicate that cathepsin S acts not only as a crucial role in antigen presentation but also as an important protagonist of cancers. "
10/18/2004 - "While it is likely that there are multiple targets of Au(I) in vivo, inhibition of the cathepsins would provide protection against the joint destruction that is a hallmark of rheumatoid arthritis and is one possible mechanism for Au(I) antiarthritic activity."
05/01/2011 - "The findings in this study support further investigation in the regulation of the activity of cathepsins and their inhibitors in erosive rheumatoid arthritis."
05/25/2005 - "Since rheumatoid arthritis is at the same time an inflammatory and joint destructive disorder, the combined inhibition of both cathepsins S and K should be beneficial. "
08/01/2004 - "In addition, these data suggest that the impact of cathepsins B and X on tissue degradation is more pronounced in aseptic prosthetic loosening than in rheumatoid arthritis."
01/01/1987 - "Cathepsin activity of blood serum and synovial fluid in patients with seropositive and seronegative rheumatoid arthritis."
03/01/2009 - "This study shows that disruption of BmNPV fp25K attenuates the expression of viral cathepsin gene (v-cath) at a late stage of infection, and thus reduces the secretion of its product V-CATH. "
12/01/2015 - "Interestingly, cathepsins and trypsin2 were downregulated at 7 days post-infection (dpi) in coho salmon. "
05/01/2015 - "Expression of Hesp018 also reduced caspase activity induced by baculovirus infection, but caused increased cathepsin activity. "
07/01/2013 - "Diagnosis of Fasciola gigantica infection using a monoclonal antibody-based sandwich ELISA for detection of circulating cathepsin B3 protease."
02/01/2012 - "Details of the molecular events following cathepsin-dependent trimming of GP(1) are currently incomplete; however, the processed GP(1) specifically interacts with endosomal/lysosomal membranes that contain the Niemann Pick C1 (NPC1) protein and expression of NPC1 is required for productive infection, suggesting that GP/NPC1 interactions may be an important late step in the entry process. "
01/01/2001 - "In the present study we examined the concentration of cathepsins B, L and H in three drug-resistant clones isolated from human laryngeal carcinoma (HEp2). "
04/01/2014 - "Cathepsin has already been used along with other genes as a prognostic parameter for carcinoma patients in gene arrays. "
09/01/2013 - "Here we identify enhanced proteasomal degradation and cathepsin-mediated proteolysis as important mechanisms for hypoxic MYC inhibition in human colon carcinoma cells. "
08/01/2013 - "The potential of the developed (18) F-labelled probe to image tumour-associated cathepsin activity was investigated by dynamic small-animal PET imaging in nude mice bearing tumours derived from the human NCI-H292 lung carcinoma cell line. "
01/01/2013 - "The latter shows no changes in the activity of cathepsins in lysosomes of tissue carcinomas category N1. "
12/01/2013 - "Recent studies have reported that lysosomal cathepsins could induce vascular remodeling and AAA formation by regulating vascular inflammation, medial smooth muscle cell apoptosis, neovascularization, and protease expression. "
01/01/2015 - "Based on our data, cathepsin activity monitored by ABPs correlated well with OA severity and joint inflammation, directing towards a novel etiological target for OA, which possesses significant translational potential in developing means for non-invasive detection of early signs of OA."
04/01/2014 - "Furthermore, in inflammation-induced neurodegeneration the cathepsins expressed in activated microglia play a pivotal role in neuronal death. "
02/01/2014 - "Both cathepsin or metalloproteinase-activated NIRF probes can detect and quantify colonic inflammation ex vivo. "
02/01/2013 - "Heritable insufficient or excess functions of CysHis cathepsins are associated with dysfunctional inflammation and immunity/auto-immunity, including diabetic pathogenesis."
|2.||Peptide Hydrolases (Proteases)
|3.||Cysteine Proteases (Cysteine Protease)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)