|1.||Liaudet-Coopman, Emmanuelle: 11 articles (09/2015 - 08/2002)|
|2.||Saftig, Paul: 11 articles (03/2013 - 02/2003)|
|3.||Isidoro, Ciro: 11 articles (02/2013 - 02/2002)|
|4.||Tyynelä, Jaana: 9 articles (02/2013 - 01/2003)|
|5.||Castino, Roberta: 8 articles (01/2010 - 02/2002)|
|6.||Laurent-Matha, Valérie: 7 articles (09/2015 - 01/2005)|
|7.||Derocq, Danielle: 7 articles (09/2015 - 08/2002)|
|8.||Follo, Carlo: 7 articles (02/2013 - 01/2006)|
|9.||Uchiyama, Yasuo: 6 articles (03/2013 - 02/2003)|
|10.||Prébois, Christine: 6 articles (12/2012 - 01/2005)|
01/01/2010 - "While representative histologic sections from various disease-specific cohorts confirm previous findings that increased Cathepsin D production and secretion correlate with tumor progression, we report no difference in serum Cathepsin D activity between patients who are disease free, patients with pre-invasive or limited invasive disease, and patients with metastatic disease. "
05/01/2002 - "The cathepsin D levels, neither in the stroma nor in the tumor, showed no influence neither on the disease free intervals nor in the survival rates (p = 0.785; p = 0.355 and p = 0.614; p = 0.601 respectively). "
01/01/2012 - "The present study aims to assess the expression of Cathepsin D in malignant salivary gland tumors and to compare its expression in these tumors. "
07/01/2011 - "Mechanistic studies revealed that OLFM4 may exhibit its anticancer effects through regulating cell autophagy by targeting cathepsin D, as OLFM4 reduced cathepsin D protein levels and enzymatic activity and attenuated cathepsin D-induced cancer cell proliferation. "
01/07/2010 - "Earlier studies indicated that density-arrested cancer cells released an unidentified growth inhibitor whose secretion was prevented by overexpression of the lysosomal protease cathepsin D (cath D). "
|2.||Breast Neoplasms (Breast Cancer)
03/01/2000 - "Invasive breast cancer patients were followed for up to 75 months to determine if the relative percentage amount of the 31 kDa form of cathepsin D was predictive of disease-free and overall survival. "
10/01/1992 - "Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival."
01/01/1991 - "Therefore, measurement of cathepsin D appears to provide additional prognostic information for the prediction of disease-free and overall survival in patients with node negative breast cancer."
10/01/2013 - "The aim of this study was to evaluate clinical usefulness of cathepsin D status in early breast cancer during the first 3 years of follow-up. "
04/01/2005 - "This study suggests that elevated intratumoral cathepsin D levels may identify a subset of node-positive breast cancer patients showing a high probability of earlier death."
01/01/2005 - "Cathepsin D-related disease-free interval in pT1 primary breast carcinomas: a pilot study."
06/01/2012 - "To study the function of lymphangiogenesis and the expression of Cathepsin D (Cath-D) in laryngeal carcinoma metabasis and clinical pathology character. "
01/01/2008 - "The aim of the study was to determine the activity of cathepsin D (CTSD) and alpha-1-antitrypsin (AAT) in the blood serum of women with cervical carcinoma treated with different modes of therapy. "
09/01/2005 - "THE AIM of this study was to determine the activity of cathepsin D and alpha(1)-antitrypsin in the blood serum of patients with mammary carcinoma. "
05/01/2004 - "We have conducted a statistically powerful study of the prognostic value of conventional factors and of the investigational factors p53, Her2-neu and Cathepsin-D in patients with invasive breast carcinoma, in order to compare their significance. "
|4.||Neoplasm Metastasis (Metastasis)
02/15/2000 - "We then summarize results of studies, mostly performed in our laboratory, aimed at understanding the effect of cathepsin D overexpression on metastasis and the molecular mechanisms involved. "
12/01/1999 - "Cathepsin-D is a potential independent predictor of cervical lymph node metastasis in HNSCC and merits additional study."
09/03/1994 - "Results obtain in our laboratory over the last 15 years allowed us to define cathepsin D, an oestrogen-regulated protein now under study as a prognostic marker for metastasis. "
01/01/2009 - "In a group of patients who survived one year post surgery, the percentage of cases with negative epithelial cathepsin D staining and without features of distant metastasis were higher. "
01/01/2009 - "The only factors significantly influencing one-year survival were epithelial cathepsin D staining and distant metastasis. "
06/01/1995 - "Cathepsin D immunoreactivity was detected in marginal areas of amyloid deposits in spleens from patients with reactive amyloidosis. "
11/18/1996 - "A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D."
10/01/1975 - "The reduced incidence of amyloidosis following BAPN adminsitration cannot be due to lysosomal enzyme degradation of the amyloid as the activity of cathepsin D and acid phosphatase is decreased during this process."
06/01/1985 - "Levels of serum amyloid A (SAA) and the activities of cathepsin D, beta-N-glucosaminidase, serine esterase, lactate dehydrogenase (LDH) and gamma glutamyl transpeptidase (GGT) were measured in the blood plasma during induction of amyloidosis. "
04/01/2007 - "Proteins that were up-regulated in GBS included haptoglobin, serine/threonine kinase 10, alpha-1-antitrypsin, SNC73, alpha II spectrin, IgG kappa chain and cathepsin D preprotein, while transferrin, caldesmon, GALT, human heat shock protein 70, amyloidosis patient HL-heart-peptide 127aa and transthyretin were down-regulated. "
|2.||Amyloid (Amyloid Fibrils)
|3.||DNA (Deoxyribonucleic Acid)
|7.||RNA (Ribonucleic Acid)
|8.||Transferrin Receptors (Transferrin Receptor)
|9.||Lysosome-Associated Membrane Glycoproteins
|1.||Drug Therapy (Chemotherapy)
|3.||Surgical Instruments (Clip)
|4.||Renal Dialysis (Hemodialysis)