|1.||Weinberger, Daniel R: 18 articles (05/2011 - 08/2003)|
|2.||Diatchenko, Luda: 10 articles (11/2014 - 12/2006)|
|3.||Smeraldi, Enrico: 9 articles (02/2015 - 05/2002)|
|4.||Müller, Thomas: 8 articles (02/2015 - 03/2006)|
|5.||Lorenzi, Cristina: 8 articles (02/2015 - 05/2002)|
|6.||Goldman, David: 8 articles (12/2006 - 01/2002)|
|7.||Nackley, Andrea G: 7 articles (11/2015 - 12/2006)|
|8.||Pirovano, Adele: 7 articles (02/2015 - 05/2002)|
|9.||Soares-da-Silva, Patrício: 7 articles (03/2014 - 11/2003)|
|10.||Gogos, Joseph A: 7 articles (10/2012 - 12/2003)|
|1.||Parkinson Disease (Parkinson's Disease)
01/01/2002 - "Inhibition of the catechol-O-methyltransferase (COMT) is an effective treatment for end-of-dose fluctuations in advanced Parkinson's disease. "
01/01/2014 - "The development of new catechol-O-methyltransferase inhibitors has led to an improvement in the treatment of Parkinson's disease. "
04/01/2015 - "In previous study, we have found the catechol-O-methyltransferase (COMT) Val158Met polymorphism may be associated with the risk of Parkinson's disease (PD) in Asians, especially Japanese population. "
01/01/2015 - "In previous study, we have found the catechol-O-methyltransferase (COMT) Val158Met polymorphism as an associated risk factor for Parkinson's disease (PD) in Asian rather than Caucasian populations. "
01/01/2006 - "A preliminary study by our group suggested an association between daytime sleepiness and the catechol-O-methyltransferase (COMT) val158met polymorphism (rs4680) in patients with Parkinson disease (PD). "
|2.||Schizophrenia (Dementia Praecox)
12/01/2012 - "Association study between the rs165599 catechol-O-methyltransferase genetic polymorphism and schizophrenia in a Brazilian sample."
11/01/2012 - "In this study, we investigated whether the siblings of patients with schizophrenia have deficits in cognition and psychosocial functioning and whether the psychosocial functioning and cognitive deficits correlate with the methylation status of the membrane-bound catechol-O-methyltransferase (MB-COMT) gene in peripheral leukocytes. "
01/01/2012 - "Recent studies evaluating the role of catechol-O-methyltransferase enzyme (COMT) polymorphisms in the pathogenesis of schizophrenia have resulted in ambiguous findings. "
04/01/2011 - "Association study of catechol-O-methyltransferase gene polymorphisms with schizophrenia and psychopathological symptoms in Han Chinese."
12/30/2010 - "Association study of catechol-O-methyltransferase (COMT) gene Val158Met polymorphism with auditory P300 in Chinese Han patients with schizophrenia."
01/01/2015 - "Results of previous studies suggest that β-adrenoreceptor activation may augment pain, and that β-adrenoreceptor antagonists may be effective in reducing pain, particularly in individuals not homozygous for the catechol-O-methyltransferase (COMT) high-activity haplotype. "
02/01/2012 - "Several studies have suggested an association between FS, especially pain sensitivity, and polymorphism of the catechol-O-methyltransferase (COMT) gene. "
01/01/2011 - "Perhaps the prime example of this inconsistency is represented by catechol-O-methyltransferase (COMT), as its substantial association to pain sensitivity has been reported in various studies, but rejected in several others. "
11/01/2010 - "The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts. "
07/01/2015 - "Furthermore, as dopaminergic mechanisms modulate pain responses, we assessed the influence of the functional DRD2 gene polymorphism (957C>T) and the catechol-O-methyltransferase (COMT) Val158Met polymorphism on the analgesic effect of rTMS. "
05/01/2015 - "Catechol-O-methyltransferase (COMT) is an important molecule in different types of cancers. "
01/01/2015 - "Catechol-O-methyltransferase (COMT) has been reported as an important molecule in various types of cancers. "
11/01/2009 - "Influence of catechol-O-methyltransferase (COMT) genotypes on the prognosis of canine mammary tumors."
03/13/2000 - "Progression of human breast cancers to the metastatic state is linked to genotypes of catechol-O-methyltransferase."
11/01/1979 - "Catechol O-methyltransferase activity was present in all samples examined and was significantly higher in malignant tumors [549 +/- 31 (S.E.) pmol/20 min/mg protein] than in benign neoplasms (226 +/- 41 pmol/20 min/mg protein) or in normal breast tissue (133 +/- 28 pmol/20 min/mg protein). "
|5.||Mood Disorders (Mood Disorder)
03/01/2008 - "In several previous biochemical, pharmacological, and genetic studies, the catechol-O-methyltransferase (COMT) has been suggested to be involved in the pathogenesis as well as the pharmacological treatment of affective disorders. "
06/01/2013 - "Several polymorphic variants within the catechol-O-methyltransferase (COMT) gene locus have been associated with a number of diverse psychiatric phenotypes including affective disorders. "
07/01/2010 - "Catechol-O-methyltransferase (COMT) has been suggested to be involved in the pathogenesis and pharmacological treatment of affective disorders. "
10/01/2006 - "Catechol-O-methyltransferase gene variants in mood disorders in the Italian population."
10/01/1997 - "We hypothesize that either the low activity allele of catechol-O-methyltransferase is a risk factor for bipolar affective disorder in Chinese populations or is in linkage disequilibrium with a nearby susceptibility gene or polymorphism."
|1.||Levodopa (L Dopa)
|5.||Monoamine Oxidase (MAO)
|6.||Dopamine Receptors (Dopamine Receptor)
|8.||Antipsychotic Agents (Antipsychotics)
|1.||Activities of Daily Living (ADL)
|3.||Drug Therapy (Chemotherapy)