Cartilage Diseases (Cartilage Disease)

1.	Garon, Martin: 1 article (12/2004)
2.	Quenneville, Eric: 1 article (12/2004)
3.	Meunier, Michel: 1 article (12/2004)
4.	Binette, Jean-Sébastien: 1 article (12/2004)
5.	Légaré, Anne: 1 article (12/2004)
6.	Buschmann, Michael D: 1 article (12/2004)
7.	Kaitila, I: 1 article (01/2001)
8.	Pruijn, G: 1 article (01/2001)
9.	Chadwick, R: 1 article (01/2001)
10.	Pelin, K: 1 article (01/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cartilage Diseases:

1.	Transforming Growth Factor beta (TGF-beta)IBA 07/01/2004 - "A more complete understanding of the role of TGF-beta and its down-stream signals will lead to improved understanding and treatment of cartilage diseases." 08/01/2000 - "Since TGFbeta is a key factor in age-related cartilage diseases, the purpose of the present study was to determine whether TGase from aging articular chondrocytes participates in LTGFbeta activation" 06/01/2008 - "Dysregulation of TGF-beta action has been implicated in cartilage diseases such as osteoarthritis" 01/01/2006 - "CONCLUSIONS: These findings show a key role for BMP signaling during the chondrocyte maturation, occurring with loss of TGF-beta signaling with important implications for osteoarthritis and cartilage diseases." 07/01/1997 - "These differences in TGFbeta response are likely to contribute to the development of age-associated cartilage diseases such as osteoarthritis." Order ALL the reference details at left...
2.	CollagenIBA 05/01/1999 - "Increasingly severe cartilage disease was associated with progressive and selective degeneration of the collagen framework of the beak ligament at its insertion onto the thumb metacarpal" 08/01/1993 - "Our findings demonstrate a highly distinct immune response to minor matrix collagens in a destructive cartilage disease and thus strongly argue against nonspecific anticollagen immune reactions simply representing epiphenomena resulting from cartilage damage." 05/01/2007 - "Studies in chondrocytes and cartilage biopsies suggest that the cartilage disease is caused by retention of mutant COMP in the endoplasmic reticulum of chondrocytes and by disruption of the collagen network of the extracellular matrix" 03/01/1993 - "Thus, these methods will allow the identification of mutations in cartilage-specific collagen genes in patients with inherited OA and other heritable cartilage diseases from small amounts of cartilage or chondrocyte RNA or from non-cartilaginous sources." 03/01/1993 - "The identification of mutations in cartilage-specific collagen genes in inherited forms of osteoarthritis (OA) and other heritable cartilage diseases has been hampered by the difficulty in obtaining sufficient tissue to isolate RNA and by the loss of the cartilage phenotype during in vitro chondrocyte culture" Order ALL the reference details at left...
3.	OligonucleotidesIBA 01/01/1991 - "Furthermore, the use of synthetic oligonucleotides without cloning the gene of interest could increase the usefulness of the technique in studies on human cartilage diseases and possibly on other diseases." Order ALL the reference details at left...
4.	cobalt mesoporphyrin (CoMP)IBA 05/01/2007 - "Studies in chondrocytes and cartilage biopsies suggest that the cartilage disease is caused by retention of mutant COMP in the endoplasmic reticulum of chondrocytes and by disruption of the collagen network of the extracellular matrix" Order ALL the reference details at left...
5.	Collagen Type II (Type II Collagen)IBA 04/01/1994 - "Type II collagen mutations in rare and common cartilage diseases." 04/01/1992 - "The control of expression of type II collagen: relevance to cartilage disease." 04/01/1993 - "Since folding of the type II collagen polypeptides to the triple helix is initiated from the carboxyl-terminal end, it has been suggested that mutations in this region typically result in severe cartilage diseases" 07/01/1995 - "To use a recently developed procedure for analysis of blood leukocyte DNA to detect mutations in the gene for type II procollagen (COL2A1) in patients with cartilage diseases ranging from early-onset familial osteoarthritis (OA) to lethal chondrodysplasias" Order ALL the reference details at left...
6.	RNA (Ribonucleic Acid)IBA 01/26/2001 - "Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia." 03/01/1993 - "Thus, these methods will allow the identification of mutations in cartilage-specific collagen genes in patients with inherited OA and other heritable cartilage diseases from small amounts of cartilage or chondrocyte RNA or from non-cartilaginous sources." 03/01/1993 - "The identification of mutations in cartilage-specific collagen genes in inherited forms of osteoarthritis (OA) and other heritable cartilage diseases has been hampered by the difficulty in obtaining sufficient tissue to isolate RNA and by the loss of the cartilage phenotype during in vitro chondrocyte culture" Order ALL the reference details at left...
7.	Proteoglycans (Proteoglycan)IBA 07/01/1998 - "Our findings point to a pathological role for serine proteinase(s) in the development of cartilage diseases such as arthritis, possibly in a cascade which results in the activation of the enzyme(s) directly responsible for proteoglycan breakdown" 09/01/2007 - "We determined whether dynamic mechanical properties of cartilage (effective shear modulus and phase lag) measured with a handheld indenter correlated with histopathology scores, proteoglycan, and collagen content or expression of chondrocyte-specific (aggrecan, collagen II) or dedifferentiation (collagen I and III) genes in human osteoarthritic cartilage with International Cartilage Repair Society scores of 0 to 1. We observed an association between the histopathologic stage of cartilage disease and dynamic shear modulus and phase lag" Order ALL the reference details at left...
8.	Aggrecans (Aggrecan)IBA 09/01/2007 - "We determined whether dynamic mechanical properties of cartilage (effective shear modulus and phase lag) measured with a handheld indenter correlated with histopathology scores, proteoglycan, and collagen content or expression of chondrocyte-specific (aggrecan, collagen II) or dedifferentiation (collagen I and III) genes in human osteoarthritic cartilage with International Cartilage Repair Society scores of 0 to 1. We observed an association between the histopathologic stage of cartilage disease and dynamic shear modulus and phase lag" Order ALL the reference details at left...
9.	Matrix Metalloproteinase 16IBA 01/01/2008 - "The results suggest that MT3-MMP may not have a role in matrix destruction in equine cartilage diseases" Order ALL the reference details at left...
10.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/01/1992 - "Basic FGF may prove useful in articular cartilage repair, while basic FGF, IGFs and TGF-beta are among a number of growth factors and cytokines that have been implicated in cartilage disease." Order ALL the reference details at left...

Therapies and Procedures

1.	Parathyroidectomy 02/01/2001 - "This bone/cartilage disease failed to respond to phosphate supplementation, parathyroidectomy and calcitriol" Order ALL the reference details at left...
2.	Microelectrodes 12/01/2004 - "Fabrication and characterization of nonplanar microelectrode array circuits for use in arthroscopic diagnosis of cartilage diseases." Order ALL the reference details at left...
3.	Debridement 11/01/2007 - "Cartilage diseases such as Panner disease or focal radial chondropathy can be treated by arthroscopic debridement and microfracturing" Order ALL the reference details at left...

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