Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)

An enzyme that catalyzes reversibly the conversion of palmitoyl-CoA to palmitoylcarnitine in the inner mitochondrial membrane. EC 2.3.1.21.

Also Known As:

Carnitine Palmitoyltransferase II; Carnitine Palmitoyltransferase I; Carnitine Palmitoyltransferase; CPT II; Carnitine Acyltransferase I; Palmitoylcarnitine Transferase; Palmitylcarnitine Acyltransferase; Acyltransferase I, Carnitine; Acyltransferase, Palmitylcarnitine; Carnitine O Palmitoyltransferase; II, Carnitine Palmitoyltransferase; O-Palmitoyltransferase, Carnitine; Palmitoyltransferase I, Carnitine; Palmitoyltransferase II, Carnitine; Palmitoyltransferase, Carnitine; Transferase, Palmitoylcarnitine; Palmitoyl-CoA:L-carnitine O-palmitoyltransferase

Networked: 560 relevant articles (13 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - Carnitine Acyltransferases: 23
        Carnitine O-Palmitoyltransferase: 560
        Carnitine palmitoyl transferase 2 deficiency: 118
        Carnitine palmitoyl transferase 1A deficiency: 19
        human CPT1A protein
        human CPT1B protein
        human ZDHHC22 protein
        Infantile Carnitine Palmitoyltransferase II Deficiency
        Late-Onset Carnitine Palmitoyltransferase II Deficiency
        Lethal Neonatal Carnitine Palmitoyltransferase II Deficiency
        mouse CPT1B protein
        rat carnitine palmitoyltransferase-1a
        rat CPT1b protein

Experts

1.	Serra, Dolors: 9 articles (01/2022 - 03/2007)
2.	Herrero, Laura: 8 articles (01/2022 - 03/2007)
3.	Kido, Hiroshi: 8 articles (01/2019 - 10/2006)
4.	Chida, Junji: 6 articles (01/2019 - 10/2006)
5.	Miyagawa, Taku: 5 articles (10/2022 - 03/2011)
6.	López, Miguel: 5 articles (01/2022 - 03/2007)
7.	Bi, Huichang: 5 articles (06/2021 - 01/2017)
8.	Chen, Yixin: 5 articles (06/2021 - 01/2017)
9.	Gonzalez, Frank J: 5 articles (06/2021 - 02/2014)
10.	Guan, Lihuan: 5 articles (06/2021 - 01/2017)

Related Diseases

1.	Cachexia 09/01/2005 - "These changes in metabolic zonation, together with decreased CPT II activity, may contribute to the aggravation of cachexia." 09/01/2005 - "The distribution of CPT II and L-FABP (by immunohistochemistry) within the acinus was modified by cachexia: whereas CPT II positivity was restricted to the PV zone, L-FABP labelling shifted from periportal (control) to perivenous (TB) zone. " 07/15/2011 - "Impaired fatty acid oxidation mainly resulting from the decrease of carnitine palmitoyltransferase I and II activities in the liver is an important factor that contributes to cancer cachexia . " 02/01/2016 - "Previous studies have shown that L-carnitine, as the key regulator of lipid metabolism, exerts an anti-inflammatory effect in several diseases, and ameliorates the symptoms of cachexia by regulating the expression and activity of carnitine palmitoyltransferase (CPT) in the liver. " 01/01/2015 - "L-Carnitine Ameliorates Cancer Cachexia in Mice Partly via the Carnitine Palmitoyltransferase-Associated PPAR-γ Signaling Pathway."
2.	Hypoxia (Hypoxemia) 08/16/1989 - "Inhibition of carnitine acyltransferase I abolished not only the accumulation of long-chain acylcarnitines during hypoxia but also the increase in alpha 1-adrenergic receptors. " 11/01/1987 - "Furthermore, inhibition of carnitine acyltransferase I prevents not only the sarcolemmal accumulation of long-chain acylcarnitines but also the exposure of the alpha 1-adrenergic receptor, indicating that accumulation of endogenous long-chain acylcarnitines is critical to the hypoxia-induced increase in alpha 1-adrenergic receptors on adult myocytes." 01/01/1987 - "Inhibition of carnitine acyltransferase I (CAT-I) during hypoxia prevents not only the SL accumulation of LCA but also the associated electrophysiological alterations. " 12/15/2021 - "Carnitine Palmitoyltransferase 1 Regulates Prostate Cancer Growth under Hypoxia." 03/01/2017 - "In contrast, the maximal oxidative respiratory rate for PCoA, the transport of which depends on carnitine palmitoyltransferase 1 (CPT-1), decreased in the rapid-glycolytic EDL and increased in the slow-oxidative SOL, although hypoxia improved affinity for this substrate in both muscle types. "
3.	Neoplasms (Cancer) 01/01/2023 - "Recently, we found that carnitine palmitoyltransferase 1C (CPT1C) controls tumor cell proliferation and senescence via regulating lipid metabolism and mitochondrial function. " 01/20/2022 - "Carnitine palmitoyltransferase 1C (CPT1C) is a member of CPT1 family and plays a key role in cancer development and progression. " 12/01/2021 - "Carnitine palmitoyltransferase 2 (CPT2) has been demonstrated to act as a tumor promotor or suppressor in different types of cancers. " 06/01/2021 - "Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence." 01/01/2021 - "Pathway analysis comparing tumor-nonneoplastic pairs revealed significant upregulation of the hedgehog pathway based on GLI1 overexpression and significant downregulation of carnitine palmitoyltransferase 2 transcript. "
4.	Brain Diseases (Brain Disorder) 11/01/2019 - "Previous study reported the association of the thermolabile polymorphism in Carnitine Palmitoyltransferase 2 (CPT2) gene and severe syndromes of acute encephalopathy. " 11/01/2019 - "Thermolabile polymorphism of carnitine palmitoyltransferase 2: A genetic risk factor of overall acute encephalopathy." 03/01/2019 - "Acute necrotizing encephalopathy and a carnitine palmitoyltransferase 2 variant in an adult." 08/01/2013 - "This report presents the first case of recurrent encephalopathy with CPT II variations that may partially associate with pathogenesis of recurrent AEFCSE. " 01/01/2012 - "Our data suggest that the thermolabile F352C CPT II variant, found only in Japanese, might be one of the predisposing factors to trigger the pathomechanism of acute encephalopathy in the Japanese population, and that it is causally related to the severity of disease. "
5.	Fatty Liver 12/01/1999 - "Preliminary studies on hepatic carnitine palmitoyltransferase in dairy cattle with or without fatty liver." 01/01/2021 - "Here, we aimed to investigate the role of carnitine palmitoyltransferase 1A (CPT1A) in fatty liver graft injury and to explore the underlying mechanism and therapeutic potential on attenuating hepatic IRI. " 01/01/2021 - "Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition." 02/09/1996 - "Altered expression of carnitine palmitoyltransferase II in liver, muscle, and heart of mouse strain with juvenile visceral steatosis." 03/28/2023 - "This review focuses on some of the progress of CPT-II inactivity on IMM with liver fatty accumulation as a possible novel pathogenesis for NAFLD in hepatocarcinogenesis."

Related Drugs and Biologics

1.	Fatty Acids (Saturated Fatty Acids)
2.	Carnitine (L-Carnitine)
3.	2- cyclohexylidenhydrazo- 4- phenyl- thiazole
4.	Proteins (Proteins, Gene)
5.	Peroxisome Proliferator-Activated Receptors (PPAR)
6.	Glucose (Dextrose)
7.	Bezafibrate
8.	PPAR alpha
9.	Insulin (Novolin)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Drug Administration Schedule
4.	Cardiopulmonary Resuscitation (CPR)
5.	Thyroidectomy