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Cardiopulmonary Bypass (Heart-Lung Bypass)

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Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.

Also Known As:

Heart-Lung Bypass; Bypass, Cardiopulmonary; Bypass, Heart-Lung; Bypasses, Cardiopulmonary; Bypasses, Heart-Lung; Cardiopulmonary Bypasses; Heart Lung Bypass; Heart-Lung Bypasses

Networked: 6552 relevant articles (211 outcomes, 440 trials/studies) for this Therapy, Comments

Relationship Network

Therapy Context: Research Results

Operative Surgical Procedures: 5
- Extracorporeal Circulation: 1725
  - Cardiopulmonary Bypass: 6552

Experts

1.	Grocott, Hilary P: 19 articles (03/2008 - 02/2002)
2.	Hetzer, Roland: 18 articles (04/2009 - 08/2002)
3.	Newman, Mark F: 15 articles (10/2007 - 02/2002)
4.	Koster, Andreas: 13 articles (01/2009 - 02/2004)
5.	Koster, A: 13 articles (01/2007 - 01/2000)
6.	Ciancio, Gaetano: 12 articles (02/2010 - 10/2002)
7.	Hetzer, R: 12 articles (06/2004 - 01/2000)
8.	Kuppe, H: 12 articles (01/2002 - 01/2000)
9.	Shernan, Stanton K: 10 articles (02/2010 - 03/2004)
10.	Mackensen, G Burkhard: 10 articles (10/2009 - 02/2002)

Related Diseases

1.	Hypothermia 04/01/2000 - "Six weeks after this, a right-sided vertebral-to-carotid artery anastomosis was performed during cardiopulmonary bypass (CPB)-induced deep hypothermia for optimal neuronal protection, with good results. " 01/01/1997 - "The application of a cardiopulmonary bypass and hypothermia in high level vena cava thrombi is an important advance that has improved the safety and technical efficacy of a difficult surgical undertaking." 03/01/2008 - "BACKGROUND: Clinical studies have failed to demonstrate significant benefits of hypothermia for the prevention of postoperative cognitive dysfunction (POCD) after cardiopulmonary bypass (CPB). " 01/01/2008 - "CONCLUSION: This successful resuscitation of an 82-year-old patient demonstrates that a prompt intervention by a medical team that trains together, using a mobile cardiopulmonary bypass device via a percutaneous approach, can potentially provide good outcomes for all victims of deep accidental hypothermia, both in the operating suites and the emergency department." 12/01/2001 - "He was treated successfully with cardiopulmonary bypass and hypothermia. " Order ALL the reference details at left...
2.	Hemorrhage 12/01/2001 - "Although extracorporeal circulation can modify platelet numbers and function, our ongoing data could show significant reduction in the loss of platelets induced by cardiopulmonary bypass, minor postoperative bleeding, and a minor transfusion requirement in general." 03/01/2009 - "Antifibrinolytic therapy is effective in reducing postoperative bleeding and allogeneic transfusion in patients undergoing cardiac surgery with cardiopulmonary bypass. " 01/01/2008 - "It is effective in reducing bleeding and the need for blood transfusions after cardiac surgery with cardiopulmonary bypass. " 04/01/1996 - "The SB tube is effective for controlling the hemorrhage until cardiopulmonary bypass can be performed to allow repair." 08/01/1999 - "The purpose of this study was to examine the efficacy of epsilon-ACA administered after heparinization but before cardiopulmonary bypass in reducing bleeding and transfusion requirements after primary coronary artery bypass surgery. " Order ALL the reference details at left...
3.	Ischemia 09/01/1992 - "A high index of suspicion for mesenteric ischemia after cardiopulmonary bypass in patients with identified risk factors may decrease the diagnostic delay and lead to an improvement in the 67% mortality rate seen in this series." 03/01/2009 - "Small human trials of hyperbaric oxygen therapy in focal ischemia have not shown benefit, although one trial of hyperbaric oxygen therapy before cardiopulmonary bypass demonstrated improved neuropsychological and inflammatory outcomes with hyperbaric oxygen therapy. " 06/01/2004 - "We examined the pre- and intraoperative characteristics of 2417 patients from 24 diverse United States medical centers enrolled in the Multicenter Study of Perioperative Ischemia Study who were undergoing cardiac surgery using cardiopulmonary bypass as predictors for adverse GI outcome. " 05/01/2003 - "The present study was designed to evaluate the effect of different cardioplegic methods on myocardial apoptosis and coronary endothelial injury after global ischemia, cardiopulmonary bypass (CPB), and reperfusion in anesthetized open-chest dogs. " 12/01/1999 - "METHODS: To study the effect of preservation solutions on recovery of myocardial metabolism and function after warm ischemia, 10 dogs underwent 30 minutes of warm global ischemia under cardiopulmonary bypass. " Order ALL the reference details at left...
4.	Heart Arrest (Cardiac Arrest) 08/01/1990 - "Previous studies in dogs have shown resuscitation from prolonged cardiac arrest to conscious survival to be more effective with the use of cardiopulmonary bypass (CPB) than with standard advanced cardiac life support. " 06/01/1997 - "Endovascular cardiopulmonary bypass using the endoaortic clamp was effective in achieving cardiac arrest and myocardial protection to allow internal mammary artery to coronary artery anastomosis in a still and bloodless field. " 12/01/2008 - "In our study, we evaluated the efficacy of portable percutaneous cardiopulmonary bypass (PPCPB) for rewarming and providing cardiovascular support in the hemodynamically unstable ADH patients without cardiopulmonary arrest. " 07/01/1978 - "This study describes ultrastructural, enzymatic, and functional assessments of the efficacy of three infusates (Bretschneider, Kirsch, and St. Thomas' Hospital) in a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest. " 12/01/2008 - "The efficacy of cardiopulmonary bypass (CPB) rewarming has been proved in ADH patients with cardiopulmonary arrest; however, its efficacy in the ADH patients without cardiopulmonary arrest remains controversial. " Order ALL the reference details at left...
5.	Reperfusion Injury 08/01/1993 - "These results suggest that, in the clinical setting, leucocyte depletion during cardiopulmonary bypass provides effective protection against reperfusion injury." 02/01/2005 - "CONCLUSION: The study demonstrated that hANP improves ischemic reperfusion injury and suggested that hANP exerts direct myocardial protection against myocardial injury associated with cardiac surgery (cardioplegic arrest while cardiopulmonary bypass)." 01/01/2006 - "Controlled cardiac reoxygenation, as an adjunct to substrate-enhanced cardioplegia, has been shown to improve myocardial function and limit reperfusion injury when utilizing standardized hyperoxic cardiopulmonary bypass (CPB). " 01/01/2001 - "Improved myocardial protection and cardiopulmonary bypass (CPB) have limited, but not abolished, intraoperative myocardial damage due to surgical reperfusion injury after release of the aortic crossclamp. " 08/01/2005 - "By using microarray technology, this study examines myocardial gene expression responses to cardiopulmonary bypass in the absence of cardioplegic arrest and ischemia-reperfusion injury. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Aprotinin (Trasylol)
2.	Heparin (Liquaemin)
3.	crystalloid solutions
4.	Oxygen
5.	Cardioplegic Solutions
6.	Amrinone (Amrinon)
7.	Nitric Oxide (Nitrogen Monoxide)
8.	Triiodothyronine (Liothyronine)
9.	Vasopressins (Vasopressin)
10.	esmolol (Brevibloc)

Related Therapies and Procedures

1.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
2.	Deep Hypothermia Induced Circulatory Arrest
3.	Induced Heart Arrest (Cardioplegia)
4.	Resuscitation
5.	Transplants (Transplant)

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