Alcoholic Cardiomyopathy

Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).

Also Known As:

Networked: 188 relevant articles (6 outcomes, 21 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sudden Death
2.	Myocarditis (Carditis)
3.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
4.	Heart Failure
5.	Poisoning

Experts

1.	Ren, Jun: 14 articles (01/2021 - 01/2003)
2.	Jing, Ling: 13 articles (12/2019 - 07/2008)
3.	Zhou, Li-jun: 8 articles (01/2012 - 07/2008)
4.	Fernández-Solà, Joaquim: 7 articles (02/2020 - 01/2002)
5.	Li, Wei-min: 7 articles (01/2012 - 07/2008)
6.	Sang, Ying: 5 articles (01/2012 - 01/2011)
7.	Song, Jian: 5 articles (01/2011 - 07/2008)
8.	Li, Shuang: 4 articles (01/2012 - 09/2008)
9.	Yuan, Lin: 4 articles (01/2012 - 01/2011)
10.	Sacanella, Emilio: 4 articles (09/2011 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Alcoholic Cardiomyopathy:

1.	Ethanol (Ethyl Alcohol)IBA 02/05/2002 - "In patients with alcoholic cardiomyopathy, both abstinence and controlled drinking of up to 60 g of ethanol per day (four standard drinks) were comparably effective in promoting improvement in cardiac function." 01/01/2021 - "The occurrence of metabolic damages in myocardial tissue in cases of alcoholic cardiomyopathy is a vivid reflection of the toxic effects on the cardiac muscle of ethanol and its metabolites. " 02/22/2020 - "The Effects of Ethanol on the Heart: Alcoholic Cardiomyopathy." 01/01/2018 - "Chronic ethanol (EtOH) consumption causes early detrimental consequences in many tissues including the myocardium, though the molecular mechanisms leading to the alcoholic cardiomyopathy (ACM) still remain to be elucidated. " 09/01/2016 - "More than this amount can lead to alcoholic cardiomyopathy, which is defined as alcohol toxicity to the heart muscle itself by ethanol and its metabolites. "
2.	p38 Mitogen-Activated Protein KinasesIBA 01/01/2018 - "ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin-angiotensin system inhibition in cardiomyocytes." 01/01/2022 - "Knockdown of lectin-like oxidized low-density lipoprotein-1 ameliorates alcoholic cardiomyopathy via inactivating the p38 mitogen-activated protein kinase pathway."
3.	LectinsIBA 01/01/2022 - "Knockdown of lectin-like oxidized low-density lipoprotein-1 ameliorates alcoholic cardiomyopathy via inactivating the p38 mitogen-activated protein kinase pathway."
4.	PractololIBA 05/01/1984 - "This paper reports a case of severe low output cardiac failure due to congestive (alcoholic) cardiomyopathy which was unresponsive to dopamine infusion, but which improved rapidly on intravenous practolol therapy. "
5.	Metformin (Glucophage)FDA LinkGeneric 04/01/2023 - "Thus, metformin may be a potential novel treatment approach for alcoholic cardiomyopathy."
6.	Dopamine (Intropin)FDA LinkGeneric 05/01/1984 - "This paper reports a case of severe low output cardiac failure due to congestive (alcoholic) cardiomyopathy which was unresponsive to dopamine infusion, but which improved rapidly on intravenous practolol therapy. "
7.	Endoplasmic Reticulum Chaperone BiPIBA 01/01/2019 - "Atorvastatin inhibited the expression of the ERS-related factor GRP78 in response to alcohol exposure, improved cell morphology, and enhanced lipid metabolism in a cellular model of alcoholic cardiomyopathy."
8.	Atorvastatin (Lipitor)FDA Link 01/01/2019 - "Atorvastatin inhibited the expression of the ERS-related factor GRP78 in response to alcohol exposure, improved cell morphology, and enhanced lipid metabolism in a cellular model of alcoholic cardiomyopathy."
9.	2- amino- 3- cyano- 6- methyl- 5- (4- pyridyl)pyridineIBA 03/01/2015 - "The results of immunohistochemical studies of the sinoatrial node---???---(SAN) and the working myocardium in the patients presenting with alcoholic cardiomyopathy (ACMP) are presented. " 11/01/2004 - "Significance, of the weight and dimensions of heart as well as of fat dystrophy of cardiomyocytes and of the related detection methods is demonstrated for the diagnosis of alcoholic cardiomyopathy (ACMP). " 08/01/1989 - "The model experiment with rats was undertaken to assess a reversibility of alcoholic cardiomyopathy (ACMP). " 01/01/1981 - "A composite morpho-histo-biochemical and ultrastructural investigation of the myocardium of 50 subjects dying suddenly in the presence of alcoholic cardiomyopathy (ACMP) was carried out. " 09/01/2015 - "Immunohistochemical (IHC) methods and polymerase chain reaction (PCR) were employed to study the cases of death from alcoholic cardiomyopathy (ACMP) among the patients presenting with interstitial myocarditis who did not have this condition in their medical histories. "
10.	EnzymesIBA 07/01/1986 - "Histochemical study showed that the alterations of enzyme (both energetic and alcohol metabolism) in rats were similar to those found in the biopsy specimens from patients with alcoholic cardiomyopathy. " 09/01/2016 - "Enzymes and signal pathways in the pathogenesis of alcoholic cardiomyopathy." 01/01/1987 - "[Role of peroxisomal enzymes and lipid peroxidation in the pathogenesis of alcoholic cardiomyopathy]." 11/01/1986 - "[Characteristics of an experimental model of alcoholic cardiomyopathy by diagnostic enzyme tests]." 09/01/2011 - "Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression."

Therapies and Procedures

1.	Therapeutics 01/01/2006 - "Cardiac sympathetic nerve function, impaired due to alcoholic cardiomyopathy, was improved with beta-blocker therapy. " 07/01/1986 - "[Therapeutic physical exercise in the combined therapy of alcoholic cardiomyopathy]." 11/15/1971 - "[Alcoholic cardiomyopathy and its therapy]." 03/01/2002 - "We tried to verify utility and tolerance to peritoneal ultrafiltration in a group of subjects affected by heart failure secondary to alcoholic cardiomyopathy, refractory to conventional therapy. " 08/01/2001 - "Except abstinence, treatment of alcoholic cardiomyopathy is based on the regimen of therapy for heart failure to reduce the size of the dilated heart and to mitigate the symptoms of heart failure."
2.	Heart Transplantation (Grafting, Heart) 01/01/1998 - "[Alcoholic cardiomyopathy and heart transplantation]." 01/01/2002 - "Forty three patients including 18 with dilated cardiomyopathy (DCM), 14 with ischemic heart disease (IHD), 3 with myocarditides, 1 with alcoholic cardiomyopathy and 7 after cardiac transplantation. "
3.	Transplantation 02/01/1996 - "The unfavorable early outcome of patients receiving hearts from alcoholic donors suggests the presence of a subclinical alcoholic cardiomyopathy before transplantation and poor tolerance of rejection episodes after transplantation. " 11/01/2006 - "Before transplantation, 45.0%, 17.5%, 17.5% and 7.5% of patients were classified as IDC, CHD, alcoholic cardiomyopathy and hypertrophic cardiomyopathy. "
4.	Bed Rest (Bedrest) 11/01/1977 - "Over an 18-month period, 26 patients with alcoholic cardiomyopathy were followed in a modified bedrest program in the patients' homes. " 05/01/1971 - "Alcoholic cardiomyopathy managed with prolonged bed rest."
5.	Percutaneous Coronary Intervention 09/01/2022 - "Percutaneous Coronary Intervention Outcomes Among Patients With Alcoholic Cardiomyopathy: An Analysis of the National Inpatient Sample."