Low Cardiac Output

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742 relevant articles (43 outcomes, 43 trials/studies) found for this Disease

Description: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.

Also Known As:

Cardiac Output, Low; Output, Low Cardiac; Low Cardiac Output Syndrome

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 20552

Heart Diseases: 13044

Low Cardiac Output: 742

Signs and Symptoms Pathological Conditions

Signs and Symptoms

Low Cardiac Output: 742

Related Diseases

1.	Heart Failure
2.	Myocardial Ischemia (Ischemic Heart Diseases)
3.	Syndrome
4.	Cardiogenic Shock
5.	Hypotension (Low Blood Pressure)

Experts

1.	Chang, Anthony C: 3 articles (11/2005 - 02/2003)
2.	Alvarez, Julián: 2 articles (05/2008 - 04/2006)
3.	Dickerson, Heather A: 2 articles (11/2005 - 07/2005)
4.	del Mazo, Carlos D: 1 article (05/2008)
5.	Degrange, Marcela A: 1 article (05/2008)
6.	Botbol, Alejandro L: 1 article (05/2008)
7.	Blanco, Norberto: 1 article (05/2008)
8.	Tanus, Eduardo: 1 article (05/2008)
9.	Porcile, Rafael: 1 article (05/2008)
10.	Salvagio, Flavio: 1 article (05/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Low Cardiac Output:

1.	Dobutamine FDA LinkGeneric 08/01/1988 - "Dobutamine seems to be an effective agent for the treatment of low cardiac output in asphyxiated neonates." 09/01/2003 - "Dobutamine stress echocardiography is a useful tool for assessing low cardiac output AS. " 01/01/2001 - "Treatment with dobutamine is indicated in patients in whom low cardiac output rather than elevated pulmonary pressure is the primary hemodynamic aberration. " 11/01/1999 - "We re-analysed data from 22 patients after cardiac surgery who were randomized to receive either dobutamine or placebo, and a separate group of patients who received dobutamine for low cardiac output (n = 6). " 09/15/1996 - "Eight patients with critical AS (valve area < or = 0.7 cm2), low cardiac output (< 4.0 L/min), and low mean transvalvular gradient (< or = 40 mm Hg) underwent hemodynamic assessment at baseline, after transvalvular flow was augmented with dobutamine, and after the valve opening was increased with percutaneous balloon aortic valvuloplasty. " Order ALL the reference details at left...
2.	simendan (Levosimendan)IBA 06/01/2006 - "The efficacy of levosimendan treatment for a low cardiac output status following cardiac surgery has not been established. " 05/01/2006 - "Levosimendan was safely used in a small number of pediatric patients with established low cardiac output state who demonstrated improved hemodynamics and tissue perfusion, with a tendency to reduced conventional inotrope usage, and this warrants its evaluation as an inotrope in the pediatric population." 04/01/2009 - "This study was performed to evaluate the efficacy and safety of levosimendan (LEVO) in pediatric patients with low cardiac output syndrome. " 05/01/2008 - "INTRODUCTION AND OBJECTIVES: The use of levosimendan to treat postoperative low cardiac output syndrome (LCOS) has been studied in only small patient series and in randomized trials focusing on hemodynamic variables. " 05/01/2008 - "[Levosimendan and low cardiac output syndrome. " Order ALL the reference details at left...
3.	Amrinone (Amrinon)FDA LinkGeneric 01/01/1991 - "The efficacy of amrinone was assessed in the treatment of low cardiac output states occurring within 24 h after mitral valve replacement in an open prospective trial. " 01/01/1991 - "[Hemodynamic effects of amrinone in low cardiac output after mitral valve replacement]" 08/01/1990 - "Amrinone in perioperative low cardiac output syndrome." 12/01/1989 - "Amrinone: contemporary management of the low cardiac output syndrome. " 07/01/1988 - "[Clinical and hemodynamic multicenter study of the effect of intravenous amrinone in the treatment of low cardiac output after valvular replacement]" Order ALL the reference details at left...
4.	dopexamineIBA 10/01/1992 - "Titration of dopexamine, 1 to 4 micrograms/kg/min, was efficacious in producing circulatory improvement in patients with a low cardiac output after cardiac surgery." 01/01/1999 - "Dopexamine is a synthetic catecholamine used for the management of low-cardiac-output states. " 05/01/1997 - "CLINICAL RELEVANCE: Dopexamine has a hemodynamic profile suited to treatment of low cardiac output in anesthetized horses; however, at the dosage rate studied (4 micrograms/kg/min), its administration was associated with a number of undesirable adverse effects which could preclude its clinical use." 06/01/1994 - "Dopexamine hydrochloride (Dopacard) is the novel synthetic catecholamine designed for use in the acute management of a low cardiac output status. " 10/01/1993 - "BACKGROUND: Recently, dopexamine (DX), which acts via adrenergic beta 2 and dopaminergic DA1 receptors, has been introduced in the treatment of low cardiac output states. " Order ALL the reference details at left...
5.	EnoximoneIBA 06/01/1997 - "[Enoximone in the treatment of postoperative low cardiac output syndrome in pediatric heart surgery. " 12/01/1995 - "In turn, the PDE III-inhibitor enoximone has been used for several years to treat low cardiac output syndrome. " 03/01/1991 - "We conclude that enoximone, single or in association with other inotropics, should be considered a drug of choice in patients undergoing cardiac surgery who develop a low cardiac output syndrome." 11/01/1990 - "Low cardiac output and enoximone." 05/01/1990 - "Management of low cardiac output syndrome after cardiac surgery using enoximone." Order ALL the reference details at left...
6.	Carbon MonoxideIBA 05/01/2008 - "OBJECTIVE: This study was undertaken to validate the transpulmonary thermodilution cardiac output measurement (CO(TPTD)) in a controlled newborn animal model under various hemodynamic conditions with special emphasis on low cardiac output. " 06/01/2009 - "Three (5.4%) patients had low Cardiac Output (CO) after operation. " 10/01/2007 - "The utility of CVA-CO2 and SVA-CO2 tension gradient appeared to be limited to their negative predictive value to exclude a low cardiac output state when CVA-CO, or SVA-CO, tension gradient was normal (< or =5 mmHg)." 06/01/1981 - "Temporary cardiac pacing (CP) is frequently applied postoperatively in the management of low cardiac output (CO) and rhythm instability. " 06/01/2008 - "This may, in part, result from low cardiac output (CO), reduced mean arterial pressure (MAP), and venous congestion. " Order ALL the reference details at left...
7.	Epinephrine (Adrenaline)FDA LinkGeneric 03/01/1991 - "In this patient, adrenaline perfusion improved the low cardiac output syndrome but resulted in poorly tolerated side effects. " 04/01/1966 - "Experimental study and clinical use of epinephrine for treatment of low cardiac output syndrome." 04/01/1996 - "In patients with direct femoral artery cannulation risk factors appear to be: arteriopathy (p<0.001), prolonged extra corporeal circulation (p<0.001), low cardiac output syndrome (p<0.001), continuous i.v. infusion of epinephrine (p<0.0001). " 01/01/1985 - "[High-dosage adrenaline therapy in low cardiac output syndrome following aortic valve replacement]" 02/01/1974 - "The use of large doses of adrenaline and other vasopressors in the low cardiac output syndrome after cardiac surgery--a report of four cases." Order ALL the reference details at left...
8.	Dopamine (Intropin)FDA LinkGeneric 02/01/1981 - "However, he had persistent mental obtundation and low cardiac output, and adverse chronotropic responses to high doses of dopamine developed. " 04/01/1980 - "The hemodynamic effects of dopamine were measured during the immediate postoperative period in five infants with low cardiac output following repair of congenital cardiac defects. " 05/01/1977 - "Hemodynamic responses to dopamine infusion at controlled normal and low cardiac output states in the anesthetized dog." 01/01/1976 - "[Use of dopamine in the treatment of postoperative low cardiac output after open heart surgery. " 10/01/1976 - "In ten patients dopamine was used for counteracting low cardiac output during and after operations performed with aid of extracorporeal circulation. " Order ALL the reference details at left...
9.	Milrinone (Primacor)FDA LinkGeneric 02/01/2001 - "This is a preliminary study for evaluating the efficacy of a slow induction of milrinone, so patients in low cardiac output state were excluded. " 09/01/2005 - "We assessed the effect of milrinone on myocardial function in pediatric patients with postoperative low cardiac output syndrome by index of myocardial performance in a prospective, open-label, nonrandomized, consecutive study. " 02/01/2004 - "The data used for pharmacokinetic analysis were collected in a prospective, randomized, placebo-controlled multi-center trial of milrinone as prophylaxis for the development of low cardiac output syndrome after surgery for repair of complex congenital cardiac defects. " 01/01/1992 - "Haemodynamic and biological effects of intravenous milrinone in patients with a low cardiac output syndrome following cardiac surgery: multicentre study." 09/01/2005 - "No difference was found in the values of heart rate corrected right or left ventricular ejection time prior to and while on treatment with milrinone (right ventricle: mean, 1.23 (SD-0.42) and 1.14 (SD-0.48), p = 0.29; left ventricles: mean, 1.17 (SD-0.51) and 1.13 (SD-0.48), p = 0.66) Our data support the direct myocardial effect of milrinone as part of the mechanism behind its already proven benefit in children with low cardiac output syndrome following cardiac surgery." Order ALL the reference details at left...
10.	Norepinephrine (Noradrenaline)FDA LinkGeneric 02/01/1984 - "Volume expansion versus norepinephrine in treatment of a low cardiac output complicating an acute increase in right ventricular afterload in dogs." 01/01/1980 - "This study demonstrates that hemodynamic improvement occurs in humans in low cardiac output state with simultaneous infusion of levarterenol and phentolamine. " 01/01/1980 - "A study was made of the hemodynamic effects of levarterenol and phentolamine in patients in whom low cardiac output developed following open-heart operation. " 06/01/1987 - "Treatment of low cardiac output after aortocoronary artery bypass surgery using a combination of norepinephrine and amrinone." 08/01/1984 - "Norepinephrine plus phentolamine improves regional blood flow during experimental low cardiac output syndrome." Order ALL the reference details at left...

Therapies and Procedures

1.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 04/01/2008 - "BACKGROUND AND OBJECTIVES: The use of IABP is helpful for haemodynamic stability of patients with low cardiac output and compromised left ventricular function in patients who undergo coronary artery bypass grafting. " 11/15/2006 - "This study determined whether prolonged QRS duration (QRSd; > or =120 ms) is an independent predictor of low cardiac output syndrome (LCOS) in patients with low left ventricular (LV) ejection fraction (EF) who underwent isolated coronary artery bypass grafting (CABG). " 10/01/1997 - "The purpose of this study, was to ascertain whether delayed sternal closure (DSC) could eliminate the need for an intra-aortic balloon pump (IABP) or ventricular assist device (VAD) in patients with low cardiac output syndrome (LCOS) following coronary artery bypass grafting surgery (CABG). " 07/01/1996 - "The purpose of this study was to identify patients at risk for the development of low cardiac output syndrome after coronary artery bypass. " 11/15/2006 - "Value of prolonged QRS duration as a predictor of low cardiac output syndrome in patients with impaired left ventricular systolic function who undergo isolated coronary artery bypass grafting." Order ALL the reference details at left...
2.	Cardiopulmonary Bypass (Heart-Lung Bypass) 03/01/1999 - "With improved cardiopulmonary bypass, myocardial protection, and surgical techniques the mortality rate from aortic valve replacement decreased substantially, whereas the mortality rate from mitral valve replacement remained high, largely because of low cardiac output syndrome. " 10/01/1995 - "This study examined the use of the Hemopump to treat low cardiac output syndrome after cardiopulmonary bypass. " 07/01/1991 - "These data provide further support for investigational trials of intravenous administration of T3 in the prevention or treatment of low cardiac output syndrome after cardiopulmonary bypass." 06/01/2009 - "ECLS support was required for failure to separate from cardiopulmonary bypass (n=83) or for postoperative low cardiac output state (n=97). " 06/01/2008 - "Low cardiac output syndrome (LCOS) is a common problem following cardiac surgery with cardiopulmonary bypass (CPB) in neonates and infants, and its early recognition remains a challenging task. " Order ALL the reference details at left...
3.	Counterpulsation (External Counterpulsation) 05/01/2007 - "BACKGROUND: Skeletal muscular counterpulsation (MCP) has been used as a new noninvasive technique for treatment of low cardiac output. " 05/01/2007 - "ECG-triggered muscular counterpulsation for treatment of low cardiac output." 01/01/2001 - "Post-operative low cardiac output refractory to inotropic drugs and intraaortic balloon counterpulsation required a circulatory assist device. " 06/01/1999 - "Eight patients (15.7%) had postoperative low cardiac output syndrome, requiring intraaortic balloon counterpulsation. " 11/01/1995 - "We recorded 1 death (1.7%) and 1 case of postoperative low cardiac output syndrome requiring counterpulsation (1.7%). " Order ALL the reference details at left...
4.	Transplants (Transplant) 11/01/2003 - "One patient (3.1%) died due to low cardiac output but had patent grafts at autopsy. " 08/01/2003 - "A 14-year-old Marfan patient with severely depressed preoperative LV function died from low cardiac output following composite-graft, mitral and tricuspid valve repair. " 12/01/1999 - "Ten patients (5%) received supplemental saphenous veins in addition to T-grafts for low cardiac output (n = 3), intraoperative regional ischaemia (n = 2), postoperative myocardial ischaemia (n = 2) and inadequate conduits (n = 3). " 01/01/1999 - "Electrocardiographic (ECG) changes were seen in only one of these five cases, and none of the patients had low cardiac output or other signs of graft failure at the end of the operation. " 10/01/1983 - "In the patients who had a single corrective surgical procedure there was no difference at all, but in those patients who had multiple corrective surgical procedures, hourly infusion reduced low cardiac output from 12.5% to 9.4% in multiple valve patients and from 50% to 19% in bypass graft combined with valve replacement patients. " Order ALL the reference details at left...
5.	Artificial Respiration (Mechanical Ventilation) 07/01/2008 - "A preoperative estimation of the comprehensive Aristotle score, particularly in association with myocardial dysfunction, mechanical ventilation to treat cardiorespiratory failure, atrioventricular valve regurgitation and aortic atresia may help to anticipate a high postoperative morbidity with low cardiac output syndrome." 05/01/2007 - "Complicated postoperative evolution was defined as patients requiring mechanical ventilation or presenting low cardiac output syndrome for more than 72 h. " 12/01/2005 - "A temporary epicardial pacing system was placed in six patients (four CHD, two NL; P = 0.003) following institution of mechanical ventilation and inotropic support for a low cardiac output state, and a permanent epicardial pacemaker was placed in 18 patients. " 02/01/2005 - "As seen with univariate analysis, low levels of ICU-antithrombin activity were significantly associated with higher blood loss, prolonged mechanical ventilation time and ICU stay, a higher incidence of allogeneic blood products use, surgical reexploration, low cardiac output syndrome, adverse neurologic events, thromboembolic events, renal dysfunction, and hospital mortality. " 12/01/2003 - "There were postoperative significant differences in low cardiac output syndrome (LOS) [45.6% in AMI vs 3.6% in UAP] and in prolongation of mechanical ventilation (59.1% in AMI vs 14.3% in UAP). " Order ALL the reference details at left...

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