|1.||Bagrov, Alexei Y: 11 articles (11/2015 - 12/2007)|
|2.||Fedorova, Olga V: 9 articles (11/2013 - 12/2007)|
|3.||Shapiro, Joseph I: 8 articles (06/2012 - 07/2008)|
|4.||Kiss, Robert: 7 articles (03/2013 - 09/2007)|
|5.||Newman, Robert A: 6 articles (04/2014 - 01/2008)|
|6.||Frolova, Elena V: 6 articles (11/2013 - 12/2007)|
|7.||Mijatovic, Tatjana: 6 articles (03/2013 - 09/2007)|
|8.||Yang, Peiying: 5 articles (04/2014 - 02/2008)|
|9.||Kennedy, David J: 4 articles (11/2015 - 09/2011)|
|10.||Cornelius, Flemming: 4 articles (03/2013 - 08/2009)|
11/03/2015 - "This strong voltage dependence of α2 pumps also helps explain how cardiotonic steroids, which block NKA pumps, can be a beneficial treatment for heart failure: by only inhibiting the α2 pumps, they selectively reduce NKA activity during the cardiac action potential, leading to an increase in systolic Ca(2+), due to reduced extrusion through the Na/Ca exchanger, without affecting resting Na(+) and Ca(2+) concentrations. "
10/01/1985 - "Congestive heart failure can be effectively treated without cardiac glycosides. "
08/01/2015 - "Although there may be promise in cardiac glycosides for treating heart failure in people living with HIV, clinical studies are needed to validate in vitro findings. "
09/01/2001 - "In the article, data from the published literature are summarized together with results of the author's investigations relevant to aspects of pharmacotherapeutical efficacy of cardiac glycosides, plants endowed with antihypertensive and diuretic activities in acute and chronic heart failure. "
03/09/1999 - "Cardiac glycosides have played a prominent role in the therapy of congestive heart failure since William Withering codified their use in his late 18th century monograph on the efficacy of the leaves of the common foxglove plant (Digitalis purpurea). "
|2.||Hypertension (High Blood Pressure)
01/01/2011 - "A potential role for these so-called endogenous cardiotonic steroids (CS) has been explored, and it has become apparent that such compounds are elevated and may play an important role in a variety of physiological and pathophysiological conditions such as hypertension and CHF. "
12/01/2010 - "Endogenous cardiotonic steroids and salt-sensitive hypertension."
11/01/2010 - "Plasma cardiotonic steroids are significantly elevated in patients with essential hypertension and in salt-dependent hypertensive animals. "
08/01/2007 - "Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth."
09/01/2006 - "Endogenous cardiac glycosides, which may contribute to salt-dependent hypertension, seem to be necessary for NCX1-mediated hypertension. "
01/01/1999 - "Despite the documented efficacy of cardiac glycosides in improving symptoms in patients with heart failure caused by systolic ventricular dysfunction, considerable debate continues as to whether the use of this class of drugs should continue into the next millennium. "
10/01/1993 - "Although supported by 2 centuries of anecdotal clinical evidence, the safety and efficacy of the cardiac glycosides for the treatment of congestive heart failure due to systolic ventricular dysfunction had never been rigorously examined by prospective clinical trials until the past decade. "
03/09/1999 - "Moreover, despite the fact that the molecular target for the cardiac glycosides, the alpha-subunit of sarcolemmal Na+K+-ATPase (or sodium pump) found on most eukaryotic cell membranes, has been known for several decades, it remains controversial whether the sympatholytic or positive inotropic effects of these agents is the mechanism most relevant to relief of heart failure symptoms in humans with systolic ventricular dysfunction. "
01/01/2014 - "Recent data suggest that cardiac glycosides may also be useful in the treatment of cancer. "
05/01/2015 - "Well-designed randomized clinical trials with reasonable sample sizes are certainly warranted to confirm the efficacy and safety of cardiac glycosides for the treatment of cancer."
10/01/2014 - "A series of cardiac glycosides were isolated and identified from the anti-tumor fraction of the root of Streptocaulon juventas in previous studies. "
09/01/2014 - "Taking into account the narrow safety range of cardiac glycosides used in clinic, this series shows a selectivity index higher than 3 for three of the cancer cell lines assayed, increasing their interest for further study. "
01/01/2014 - "This paper reviews such evidence and discusses experimental approaches that could be used to reveal the cancer therapeutic potential of cardiac glycosides in preclinical studies. "
|5.||Cardiac Arrhythmias (Arrythmia)
01/01/2014 - "Cardiac glycosides have been used for many years in the treatment of cardiac congestion and some types of cardiac arrhythmias. "
01/01/1986 - "Cardiac glycosides also produce abnormal pacemaker activity and cardiac arrhythmias. "
09/01/1977 - "The tactics of treatment with cardiac glycosides is determined by precise diagnosis of the arrhythmia and its connection with digitalis toxicosis."
01/01/1967 - "[Effect of cardiac glycosides on the statistical distribution of R-R ventricular distances in complete arrhythmia]."
09/08/1962 - "[Arrhythmia in therapy with cardiac glycosides]."
|2.||Vasodilator Agents (Vasodilators)
|6.||Ouabain (G Strophanthin)
|8.||Sodium-Potassium-Exchanging ATPase (Sodium, Potassium ATPase)
|9.||Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
|10.||Adenosine Triphosphate (ATP)
|1.||Heterologous Transplantation (Xenotransplantation)
|3.||Renal Dialysis (Hemodialysis)
|5.||Drug Therapy (Chemotherapy)