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Cardiac Glycosides

Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Also Known As:
Glycosides, Cardiac; Steroids, Cardiotonic; Cardiotonic Steroids
Networked: 460 relevant articles (23 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bagrov, Alexei Y: 11 articles (11/2015 - 12/2007)
2. Fedorova, Olga V: 9 articles (11/2013 - 12/2007)
3. Shapiro, Joseph I: 8 articles (06/2012 - 07/2008)
4. Kiss, Robert: 7 articles (03/2013 - 09/2007)
5. Newman, Robert A: 6 articles (04/2014 - 01/2008)
6. Frolova, Elena V: 6 articles (11/2013 - 12/2007)
7. Mijatovic, Tatjana: 6 articles (03/2013 - 09/2007)
8. Yang, Peiying: 5 articles (04/2014 - 02/2008)
9. Kennedy, David J: 4 articles (11/2015 - 09/2011)
10. Cornelius, Flemming: 4 articles (03/2013 - 08/2009)

Related Diseases

1. Heart Failure
2. Hypertension (High Blood Pressure)
3. Ventricular Dysfunction
4. Neoplasms (Cancer)
5. Cardiac Arrhythmias (Arrythmia)

Related Drugs and Biologics

1. Digoxin (Digitek)
2. Vasodilator Agents (Vasodilators)
3. Calcium
4. Diuretics
5. Oxygen
6. Ouabain (G Strophanthin)
7. Digitoxin
8. Sodium-Potassium-Exchanging ATPase (Sodium, Potassium ATPase)
9. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
10. Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Premedication
3. Renal Dialysis (Hemodialysis)
4. Therapeutics
5. Drug Therapy (Chemotherapy)