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Scirrhous Adenocarcinoma (Scirrhous Carcinoma)

An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (From Dorland, 27th ed)
Also Known As:
Scirrhous Carcinoma; Adenocarcinoma, Scirrhous; Adenocarcinomas, Scirrhous; Carcinomas, Scirrhous; Scirrhous Adenocarcinomas; Scirrhous Carcinomas; Carcinoma, Scirrhous
Networked: 113 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Adenocarcinoma
2. Neoplasms (Cancer)
3. Carcinoma (Carcinomatosis)
4. Stomach Neoplasms (Stomach Cancer)
5. Fibrosis (Cirrhosis)

Experts

1. Yanagihara, Kazuyoshi: 4 articles (01/2012 - 07/2007)
2. Takigahira, Misato: 3 articles (01/2012 - 07/2007)
3. Sakai, Ryuichi: 3 articles (01/2009 - 07/2007)
4. Tanaka, Masamitsu: 3 articles (01/2009 - 07/2007)
5. Adachi, Keita: 2 articles (12/2021 - 12/2020)
6. Hirano, Tomohiro: 2 articles (12/2021 - 12/2020)
7. Sakurai, Kenichi: 2 articles (12/2021 - 12/2020)
8. Suzuki, Shuhei: 2 articles (12/2021 - 12/2020)
9. Ishiyama, Tomoharu: 2 articles (03/2015 - 11/2014)
10. Jinguu, Akira: 2 articles (03/2015 - 11/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Scirrhous Adenocarcinoma:
1. Fluorouracil (Carac)FDA LinkGeneric
2. PicibanilIBA
3. EnzymesIBA
4. CollagenIBA
5. Monoclonal AntibodiesIBA
6. Transforming Growth Factor beta (TGF-beta)IBA
07/01/1991 - "These results suggest that the activated form of TGF-beta released from gastric scirrhous carcinoma cells stimulates fibroblasts to contract the collagenous stroma of the stomach wall, which leads to the so-called "linitis plastica" stomach condition."
12/01/2000 - "Hence, the majority of studies examining the role of TGF-beta in gastric carcinoma have focused on scirrhous carcinoma.METHODS: We undertook a retrospective immunohistochemical study of gastric carcinoma in order to characterize TGF-beta expression in malignant gastric lesions and to determine whether TGF-beta expression was related to disease progression.RESULTS: TGF-beta expression in scirrhous gastric carcinomas was significantly higher than that in nonscirrhous gastric carcinomas. "
04/01/1994 - "To explore the mechanism of increased collagen deposition in scirrhous carcinoma of the stomach, an attempt was made to define the role of transforming growth factor beta 1 (TGF-beta 1), secreted from tumour cells, as a possible humoral factor which functions in a paracrine manner to stimulate the production of collagen in regional fibroblasts. "
04/01/1988 - "Recent in vivo and in vitro evidence suggests that EGF-related growth factors and TGF beta derived from tumor cells mutually act not only on tumor cells themselves but also on fibroblasts surrounding the tumor, resulting in extensive progression and fibrosis of gastric scirrhous carcinoma. "
04/01/1988 - "However, the expressions of the EGF-related growth factors, TGF beta and procollagen, in tumor cells are not specific for gastric scirrhous carcinoma. "
7. GlycosaminoglycansIBA
8. Dacarbazine (DIC)FDA LinkGeneric
9. Culture MediaIBA
10. Telomerase (Telomerase Reverse Transcriptase)IBA

Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Neoadjuvant Therapy
4. Gastrectomy
5. Mastectomy (Mammectomy)