Bronchogenic Carcinoma

Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.

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Networked: 2032 relevant articles (49 outcomes, 181 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Cerebellar Diseases (Cerebellar Syndrome)
3.	Neoplasm Metastasis (Metastasis)
4.	Lung Neoplasms (Lung Cancer)
5.	Asthma (Bronchial Asthma)

Experts

1.	de Perrot, Marc: 4 articles (08/2015 - 02/2003)
2.	Willey, James C: 4 articles (06/2007 - 01/2005)
3.	Malik, Abida: 3 articles (05/2014 - 07/2003)
4.	Harr, Michael W: 3 articles (06/2007 - 01/2005)
5.	Crawford, Erin L: 3 articles (01/2006 - 01/2005)
6.	Tietze, L F: 3 articles (10/2001 - 03/2000)
7.	Moro-Sibilot, D: 2 articles (09/2014 - 10/2008)
8.	Toffart, A-C: 2 articles (09/2014 - 10/2008)
9.	Souquet, P-J: 2 articles (09/2014 - 11/2004)
10.	Ding, Min: 2 articles (01/2014 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bronchogenic Carcinoma:

1.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/01/2000 - "We used a recently developed, ex vivo isolated, ventilated and perfused human lung model to study cyclophosphamide uptake into bronchial carcinoma and healthy lung tissue. " 01/01/2000 - "Variability of cyclophosphamide uptake into human bronchial carcinoma: consequences for local bioactivation." 06/01/1985 - "Acute ECG changes during cyclophosphamide infusion in a patient with bronchogenic carcinoma." 01/01/1984 - "Thirty-nine patients with histologically proven widely metastatic bronchogenic carcinoma were treated with cyclophosphamide and Corynebacterium parvum. " 01/01/1983 - "Cyclophosphamide (CP) was administered to eight patients with metastatic bronchial carcinoma in escalating doses of 1.5, 2.5, and 3.5 g/m2 at intervals of 3 weeks. "
2.	Vindesine (Vindesin)IBA 08/01/1983 - "[Phase II study of vindesine in patients with primary bronchogenic carcinoma by Cooperative Study Group]." 02/01/1982 - "Vindesine in bronchogenic carcinoma: a phase II trial." 03/01/1981 - "The antineoplastic activity of vindesine was evaluated in a phase II trial in patients with small cell anaplastic bronchogenic carcinoma. " 11/01/1983 - "Phase II evaluation of vindesine in non-small cell bronchogenic carcinoma." 02/01/1982 - "These results suggest that vindesine is well tolerated and possesses some activity in patients with previously treated bronchogenic carcinoma."
3.	Methotrexate (Mexate)FDA LinkGeneric 09/01/1975 - "Methotrexate will find its greatest potential use in combination with other drugs proven to be effective in treating bronchogenic carcinoma." 06/01/1981 - "Oral VP-16-213 in advanced bronchogenic carcinoma and toxic effects when combined with methotrexate." 09/01/1975 - "One hundred ninety-five patients with disseminated bronchogenic carcinoma were treated with 10 different dosage schedules of methotrexate. " 09/01/1975 - "Evaluation of methotrexate in the treatment of bronchogenic carcinoma." 01/01/1992 - "Etoposide versus methotrexate in small cell bronchial carcinoma. "
4.	IfosfamideFDA LinkGeneric 11/01/1981 - "This study tested the feasibility of using oral ifosfamide to treat bronchogenic carcinoma and compared the pharmacokinetics of intravenous and oral doses of the drug. " 02/01/1989 - "Comparative pharmacokinetics and alkylating activity of fractionated intravenous and oral ifosfamide in patients with bronchogenic carcinoma." 01/01/1989 - "Failure of response to ifosfamide in squamous cell bronchogenic carcinoma." 05/01/1986 - "The bioavailability of oral N,3-bis(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide (ifosfamide) (500-mg gelatine capsules) was investigated in 18 patients with bronchogenic carcinoma. " 01/01/1986 - "The pharmacokinetics of ifosfamide (I) were determined in ten patients with bronchogenic carcinoma. "
5.	Cisplatin (Platino)FDA LinkGeneric 05/01/1980 - "Phase-II study with cis-dichlorodiammineplatinum (II) in small cell anaplastic bronchogenic carcinoma." 04/01/1979 - "cis-Dichlorodiammineplatinum (II) in small cell anaplastic bronchogenic carcinoma: a phase II study." 02/01/2001 - "[Meta-analysis of the value of cisplatin in primary therapy of small-cell bronchial carcinoma]." 02/01/1987 - "[Selective bronchial artery perfusion with cisplatin in the treatment of inoperable bronchogenic carcinoma]." 01/01/1986 - "Therapy of bronchogenic carcinoma with the drug platidiam lachema."
6.	AsbestosIBA 01/01/2004 - "In this study we aimed both to determine the epidemiological findings of the patients diagnosed as bronchial carcinoma and to discuss the features, which were probably related to asbestos exposure, presented by the patients. " 01/01/1985 - "Epidemiologic and experimental studies document a synergistic effect of asbestos and smoking in the induction of bronchogenic carcinoma. " 01/01/2013 - "Bronchogenic carcinoma was seen in 1 patient exposed to asbestos. " 07/01/2010 - "Bronchial carcinoma can also be caused by asbestos exposure. " 03/01/2008 - "Asbestos-related disease and invasive bronchogenic carcinoma make up the majority of cases. "
7.	Doxorubicin (Adriamycin)FDA LinkGeneric 09/01/2001 - "[Pharmacokinetics of adriamycin by bronchial artery infusion for non-small cell bronchogenic carcinoma]." 06/01/1986 - "These results demonstrate two different mechanisms by which bronchogenic carcinomas might become resistant to the chemotherapeutic actions of Adriamycin. " 09/01/1974 - "Adriamycin in advanced bronchogenic carcinoma." 08/01/1979 - "Sequential radiotherapy and adriamycin in the management of bronchogenic carcinoma: the question of additive toxicity." 01/01/2001 - "We examined the cytotoxicity of doxorubicin alone, or in combination with docosahexaenoic acid (22:6 n-3), in glioblastoma cell lines A-172 and U-87 MG and bronchial carcinoma cell lines A-427 and SK-LU-1. "
8.	Vincristine (Oncovin)FDA LinkGeneric 05/01/1978 - "Vincristine (NSC 67574) in non-small cell bronchogenic carcinoma. " 03/01/1981 - "The study demonstrates that vindesine is active against small cell bronchogenic carcinoma, with apparent lack of clinical cross-resistance to vincristine in previously heavily treated patients." 12/01/1983 - "Comparison of vincristine and vindesine in the treatment of inoperable non-small cell bronchial carcinoma." 08/01/1980 - "The addition of procarbazine and vincristine to CA for the treatment of small cell bronchogenic carcinoma resulted in increased toxicity and no survival benefit." 04/01/1985 - "Combined methotrexate and high-dose vincristine chemotherapy with radiation therapy for small cell bronchogenic carcinoma."
9.	Fluorouracil (Carac)FDA LinkGeneric 06/01/1989 - "This article reported 797 bronchial arteriography and bronchial artery infusion using CDDP, MMC or 5-FU, in 200 patients with bronchogenic carcinoma. " 06/01/1971 - "Radiation plus 5-fluorouracil (NSC-19893): clinical demonstration of an additive effect in bronchogenic carcinoma." 10/01/1983 - "Thirty patients with locally advanced nonresectable non-small cell bronchogenic carcinoma were studied for tolerance and response to 120-hour continuously infused 5-FU (IFU) combined with chest x-ray therapy. " 02/01/1972 - "Radiotherapy plus 5-FU compared to radiotherapy alone for inoperable and unresectable bronchogenic carcinoma." 07/01/1976 - "90 out of 191 patients with bronchial carcinomas were treated exclusively with telecobalt (focal dose ofer 4,500 rad), 78 patients were given an additional treatment with Proresid, and 23 patients were additionally treated with 5-fluorouracil under so-called synchronization conditions. "
10.	Altretamine (Hemel)FDA Link 02/15/1972 - "Hexamethylmelamine in inoperable bronchogenic carcinoma." 04/01/1975 - "Hexamethylmelamine is known to be effective in humans in the treatment of certain malignant tumors, especially bronchial carcinoma. " 07/01/1981 - "Phase II study of cyclophosphamide and hexamethylmelamine in non-oat cell bronchogenic carcinoma." 04/01/1975 - "In a reexamination of the effects of hexamethylmelamine, two tumors were found to be very sensitive, namely, a mouse plasma cell tumor (PC6) and a human bronchial carcinoma (P246) growing in immune deprived mice. " 12/01/1986 - "Phase II trial of mitomycin, vindesine, and hexamethylmelamine in metastatic non-small cell bronchogenic carcinoma."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/1987 - "The high rate of locally delimited recurrences of parvicellular bronchial carcinoma, following chemotherapy and complete remission, primarily in cases of limited disease, prompted the authors to apply preoperative neoadjuvant chemotherapy to seven patients. " 03/01/1984 - "The administration of intensive ECHO induction chemotherapy to patients with extensive small cell bronchogenic carcinoma produced a high complete remission rate, although there was no significant long-term survival advantage over a program of less intensity. " 02/01/1984 - "In almost 80% of patients bronchial carcinomas with limited disease, a complete remission and a markedly prolonged median survival time can be achieved by combined cytostatic chemotherapy, e.g. " 01/15/1987 - "Administration of intensive ECHO chemotherapy to patients with small cell bronchogenic carcinoma resulted in high response rates, acceptable toxicities and improved survival. " 03/01/1990 - "Twenty-six patients with a limited-disease presentation of small-cell bronchogenic carcinoma (SCBC) had surgery after achieving a partial remission with three cycles of chemotherapy. "
2.	Radiotherapy 12/01/1979 - "Authors have shown that in some favorable cases radiotherapy of localized bronchial carcinoma could give very good results. " 10/01/2002 - "Our results demonstrate the synergism of topographical (CT) and metabolic (FDG-PET) information, which could be helpful in planning radiotherapy of bronchial carcinoma, especially for patients with disturbed ventilation." 04/01/1997 - "[Improved survival through simultaneous radiochemotherapy versus radiotherapy alone in stage III of non-small-cell bronchial carcinoma]." 01/01/1990 - "In a retrospective investigation the remission rate was determined in roentgen picture for 264 male patients with bronchogenic carcinoma after intensive radiotherapy (target dose 56 Gy). " 11/18/1972 - "[Can preoperative radiotherapy in bronchial carcinoma contribute to improved results?]."
3.	Pneumonectomy (Lung Volume Reduction) 07/01/1988 - "These results indicate that tracheal sleeve pneumonectomy for bronchogenic carcinoma with extension to the carina is now fully justified considering the low operative mortality and the good results observed when lateral tracheal lymph nodes were not involved." 01/01/1968 - "[The efficacy of expanded pneumonectomy in centrally growing bronchial carcinomas]." 09/01/1975 - "Regional pulmonary function studies using 133xenon gas, spirometry, and arterial blood gas levels were performed before and 1 to 47 months after pneumonectomy for bronchogenic carcinoma in 27 patients. " 04/01/1957 - "Involvement of the thoracic wall in bronchogenic carcinoma; study of 16 cases in which pneumonectomy or lobectomy and simultaneous resection of the thoracic wall were done." 10/01/1954 - "[Morphological studies in healing and spontaneously perforated bronchus after pneumonectomy in bronchial carcinoma]."
4.	Combination Drug Therapy (Combination Chemotherapy) 01/01/1978 - "Combination chemotherapy alone is an effective treatment of superior vena caval obstruction in patients with small-cell anaplastic bronchogenic carcinoma." 03/01/1973 - "Remission rates, survival, and prognostic factors in combination chemotherapy for bronchogenic carcinoma." 01/01/1983 - "Metastatic non-small cell bronchogenic carcinoma: a randomized trial of sequential vs combination chemotherapy." 01/01/1976 - "A preliminary evaluation of a randomized, prospective clinical study of combined polychemotherapy in bronchial carcinoma is presented. " 11/01/1998 - "[Mono- versus polychemotherapy in advanced non-small cell bronchial carcinoma]."
5.	Brachytherapy 01/01/1997 - "These results confirm the feasibility and good results related to endobronchial brachytherapy, though controlled studies are needed to better define its place in the therapeutic strategy of bronchial carcinomas." 08/01/2010 - "The results confirm the efficacy of endobronchial brachytherapy in relieving obstructive airway symptoms from endoluminal bronchogenic carcinomas. " 06/01/2010 - "This study's aim was to assess outcome and toxicity of high-dose-rate endoluminal brachytherapy (HDREB) for recurrent bronchial carcinoma. " 07/01/2003 - "In the present study, we describe the results of brachytherapy (mean dose of 18 Gy), used in combination with external beam irradiation (mean dose of 50 Gy) in 30 patients who had primary bronchogenic carcinoma of the lung. " 01/01/1998 - "The present study confirms the usefulness of endobronchial brachytherapy in alleviating symptoms caused by endobronchial recurrence of bronchogenic carcinoma. "