|5.||Lung Neoplasms (Lung Cancer)
|1.||Cadranel, Jacques: 8 articles (03/2014 - 06/2007)|
|2.||Franklin, Wilbur A: 6 articles (07/2013 - 06/2004)|
|3.||Gandara, David R: 6 articles (07/2013 - 06/2004)|
|4.||Jablons, David M: 5 articles (01/2013 - 03/2006)|
|5.||Raz, Dan J: 5 articles (09/2012 - 03/2006)|
|6.||Kris, Mark G: 5 articles (05/2011 - 01/2005)|
|7.||Kakinuma, Ryutaro: 5 articles (10/2010 - 05/2002)|
|8.||Wislez, Marie: 4 articles (03/2014 - 06/2007)|
|9.||Davies, Angela M: 4 articles (07/2013 - 06/2004)|
|10.||Noguchi, Masayuki: 4 articles (05/2013 - 05/2005)|
|1.||gefitinib (Iressa)FDA Link
04/20/2006 - "Gefitinib therapy in advanced bronchioloalveolar carcinoma: Southwest Oncology Group Study S0126."
01/01/2007 - "Here we present a case of 76-year-old Japanese female, who had never smoked, with poor performance status from bronchioloalveolar carcinoma (BAC), in whom a brief initial 5-week administration of gefitinib resulted in dramatic antitumor effects that lasted approximately 8.5 months after cessation of the treatment. "
01/01/2007 - "Short-term gefitinib treatment brought about a long-term regression of bronchioloalveolar carcinoma without EGFR gene alterations: a case report."
11/01/2005 - "Response to gefitinib in bronchioloalveolar carcinoma in the absence of EGFR mutation."
07/11/2005 - "Pathology review by a histopathologist was conducted, in particular to confirm a recently published result of bronchioloalveolar carcinoma histology or its components as predictive of response to gefitinib. "
|2.||Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
04/01/2008 - "Long-lasting complete remission with tyrosine kinase inhibitor in bronchioloalveolar carcinoma with a so far unknown EGFR mutation."
01/01/2010 - "[EGFR tyrosine kinase inhibitors as a targeted therapy for bronchioloalveolar carcinoma of the lung: a case report of a clinically prompt and intensive response and literature review]."
05/01/2007 - "Some of the traditional cytomorphological features of bronchioloalveolar carcinoma, i.e., flat monolayers, intranuclear inclusions, and the absence of macronucleoli, statistically correlated with the presence of mutations within the tyrosine kinase region of EGFR. "
10/01/2005 - "Clinical characteristics, such as never smoking status and adenocarcinoma, and especially bronchioloalveolar carcinoma histological features, can also identify individuals likely to respond to EGFR tyrosine kinase inhibitors. "
10/01/2006 - "Epidermal growth factor receptor tyrosine kinase inhibitors have shown impressive activity against bronchioloalveolar carcinoma in trials. "
|3.||Epidermal Growth Factor Receptor (EGF Receptor)IBA
01/01/2013 - "Associations between bronchioloalveolar carcinoma (BAC), mucinous differentiation, and epidermal growth factor receptor (EGFR) and KRAS mutations have been previously reported in studies of surgical specimens. "
07/01/2008 - "The percentage of non-bronchioloalveolar carcinoma (non-BAC) components quantified objectively, and epidermal growth factor receptor gene (EGFR) mutation determined by polymerase chain reaction-based assay were retrospectively linked with clinical data. "
06/01/2007 - "Most small peripheral lung lesions including bronchioloalveolar carcinoma putatively originate from the peripheral airway epithelium, in which the epidermal growth factor receptor gene is frequently mutated. "
06/15/2004 - "Bronchioloalveolar carcinoma: a model for investigating the biology of epidermal growth factor receptor inhibition."
02/01/2012 - "Epidermal growth factor receptor (EGFR) mutation has been known to be associated with adenocarcinoma with bronchioloalveolar carcinoma (BAC; lepidic) feature. "
|4.||erlotinib (CP 358,774)FDA Link
11/01/2003 - "In an ongoing phase II trial in bronchioloalveolar carcinoma, erlotinib treatment has produced objective response in 26% of 50 evaluable patients, with median duration of response not yet having been reached. "
03/01/2012 - "[A case of bronchioloalveolar carcinoma successfully treated with low-dose, alternate-day administration of erlotinib]."
03/20/2008 - "We conducted this phase II trial to determine the efficacy of erlotinib in patients with bronchioloalveolar carcinoma (BAC) and adenocarcinoma, BAC subtype, and to determine molecular characteristics associated with response. "
03/20/2008 - "Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib."
06/01/2014 - "Erlotinib or gefitinib as first-choice therapy for bronchorrhea in bronchioloalveolar carcinoma."
|5.||Messenger RNA (mRNA)IBA
01/01/2013 - "Moreover, SIX3 mRNA expression was associated with significantly improved overall survival (OS) and progression-free survival (PFS) in adenocarcinoma patients and patients with bronchioloalveolar carcinoma (BAC) features. "
02/20/2004 - "ΔNp63 mRNA overexpression was observed in 18 squamous cell carcinoma (18/23), 1 bronchioloalveolar carcinoma (1/6) and 2 paracancerous tissues of squamous cell carcinoma (2/23). "
10/01/1998 - "Forty surgically resected cases of NSCLC (24 squamous cell carcinomas, 12 ordinary type adenocarcinomas, 3 bronchiolo-alveolar carcinomas, and 1 anaplastic large cell carcinoma), in which fresh frozen material was available for mRNA analysis, were collected. "
05/01/2000 - "To investigate the molecular mechanisms underlying GM-CSF regulation, we studied GM-CSF production, messenger RNA (mRNA) expression levels, and GM-CSF promoter activity in A549 human alveolar carcinoma cells stimulated with IL-1beta. "
11/01/2000 - "Real-time quantitative reverse transcription polymerase chain reaction confirmed that radixin mRNA was decreased, both in 10 early-stage bronchioloalveolar carcinomas and in 16 invasive lung adenocarcinomas, by 69% (p = 0.0002) and 82% (p < 0.0001), respectively, compared with 9 nontumor lung tissues. "
|6.||Indomethacin (Indometacin)FDA LinkGeneric
05/01/1999 - "To our knowledge, this is the first report of successfully treated refractory bronchorrhea associated with bronchioloalveolar carcinoma by inhaled indomethacin, resulting in markedly reduced sputum volume, improved quality of life, and prolonged survival."
05/01/1999 - "Recently, we have confirmed the efficacy of inhaled indomethacin in severe refractory bronchorrhea in comparison to that of other medications in two patients with bronchioloalveolar carcinoma. "
05/01/1999 - "Successful treatment of refractory bronchorrhea by inhaled indomethacin in two patients with bronchioloalveolar carcinoma."
04/01/2000 - "Inhaled indomethacin in bronchorrhea in bronchioloalveolar carcinoma: role of cyclooxygenase."
|8.||Adenocarcinoma of lungIBA
07/01/2011 - "This study assessed the significance of EMX2 as a prognostic biomarker in lung adenocarcinoma including bronchioloalveolar carcinoma (BAC). "
06/01/2006 - "The aim of this study was to address the prognostic value of bronchioloalveolar carcinoma (BAC) component in lung adenocarcinoma. "
10/13/2015 - "Induced expression of HER2H878Y in lung epithelial compartments resulted in formation of poorly differentiated lung adenocarcinoma with bronchioloalveolar carcinoma (BAC) features. "
01/01/2014 - "We analyzed 138 consecutive patients with pathological stage IA or IB lung adenocarcinoma except pure bronchioloalveolar carcinoma (BAC) who underwent preoperative FDG-PET imaging and curative resection from January 2005 to October 2010. "
04/01/2013 - "Pure bronchioloalveolar carcinoma (BAC) is considered the early stage of lung adenocarcinoma, and is even regarded as lung adenocarcinoma in situ. "
04/01/2004 - "[A case of a slow-growing, non-mucin-producing bronchioloalveolar carcinoma with a 9-year clinical history before thoracoscopic surgery]."
10/01/2001 - "Mucinous bronchioloalveolar carcinoma (BAC) has a particular pattern of mucin gene expression indicating that it has sustained a well-differentiated phenotype similar to the goblet cell, correlated with distinctive features i.e. "
04/01/1998 - "There are three cell types described in bronchioloalveolar carcinoma: Clara cells, mucin-producing cells, and alveolar type II epithelial cells. "
05/01/2015 - "Primary pulmonary mucin-rich lesions with abundant goblet cells growing within alveolar spaces are either classified as mucinous adenocarcinoma (previously called mucinous bronchioloalveolar carcinoma) or colloid carcinoma. "
06/01/2014 - "At autopsy, lepidic predominant adenocarcinoma with aerogenous spread of mucin without evidence of invasion, a rare diagnosis that previously would have fallen under the umbrella of "bronchioloalveolar carcinoma," was found. "
|10.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/01/2004 - "In this study, we investigated the prognostic value of HER2/neu, p53, and vascular endothelial growth factor in early stage conventional adenocarcinoma and bronchioloalveolar carcinoma of the lung. "
10/01/2004 - "In the bronchioloalveolar carcinoma, HER2/neu, p53, and vascular endothelial growth factor were expressed in 9/50 (18%), 3/50 (6%) and 12/50 (24%), respectively which was significantly less than in conventional adenocarcinoma (P < 0.05). "
10/01/2004 - "Prognostic significance of HER2/neu, p53, and vascular endothelial growth factor expression in early stage conventional adenocarcinoma and bronchioloalveolar carcinoma of the lung."
02/01/2002 - "Stimulation of vascular endothelial growth factor gene transcription by all trans retinoic acid through Sp1 and Sp3 sites in human bronchioloalveolar carcinoma cells."
02/01/2002 - "In this study, we examined the effects of all trans-retinoic acid (at-RA) on the vascular endothelial growth factor (VEGF) expression in human bronchioloalveolar carcinoma NCI-H322 cells to evaluate the potential of at-RA to affect tumor progression. "
|1.||Drug Therapy (Chemotherapy)
04/01/2007 - "To analyze the clinical feature and the value of chemotherapy for advanced stage bronchioloalveolar carcinoma (BAC) of the lung. "
04/01/2007 - "[Clinical characteristics and chemotherapy of advanced-stage bronchioloalveolar carcinoma of the lung: report of 53 patients]."
10/01/2006 - "Chemotherapy has shown activity in advanced bronchioloalveolar carcinoma but response rates remain low. "
02/01/2000 - "Clinical characteristics and the impact of surgery and chemotherapy on survival of patients with advanced and metastatic bronchioloalveolar carcinoma: a retrospective study."
10/01/1997 - "He has been treated 10 months before the present complication for a diffuse bronchiolo-alveolar carcinoma with a good response to chemotherapy. "
04/01/1992 - "In this study, chemical axotomy prior to the intravenous (i.v.) injection of the alveolar carcinoma line 1 significantly increased the number of pulmonary metastases. "
04/01/1992 - "In summary, chemical axotomy of mice prior to injection of alveolar carcinoma cells resulted in an increased number of pulmonary metastases that was not correlated with alterations in either NK cell cytotoxicity or the putative immunological consequences of in vivo priming."
01/01/2012 - "Diffuse bronchiolo-alveolar carcinoma is a possible indication of lung transplantation. "
01/01/2012 - "Bronchiolo-alveolar carcinoma is a controversial indication for lung transplantation because of the risk of recurrence. "
01/01/2012 - "[Bronchiolo-alveolar carcinoma and lung transplantation]."
09/01/2005 - "Presented herein is a case of a bilateral lung transplantation for a bilateral and pneumonic form of non-mucinous bronchioloalveolar carcinoma in a 43-year-old woman. "
09/01/2005 - "Recurrence of bronchioloalveolar carcinoma in donor lung after lung transplantation: microsatellite analysis demonstrates a recipient origin."
10/01/2012 - "In this report, we examine the case of a bilateral lung transplant in a young man with bilateral bronchioloalveolar carcinoma. "
10/01/2012 - "Bilateral lung transplant for bronchioloalveolar carcinoma: first case in China."
04/08/1999 - "Seven patients with biopsy-proved bronchioloalveolar carcinoma and no evidence of extrapulmonary disease received transplants of either one or two cadaveric lungs. "
01/01/2003 - "Hence, we currently do not support lung transplantation for patients with pre-transplant diagnosis of bronchogenic carcinoma, with the exception of bronchioloalveolar carcinoma (BAC) confined to the lung. "