|2.||Neoplasm Metastasis (Metastasis)
|3.||Carcinoid Tumor (Carcinoid)
|4.||Neuroendocrine Tumors (Neuroendocrine Tumor)
|1.||Chen, Herbert: 35 articles (01/2013 - 12/2002)|
|2.||Kunnimalaiyaan, Muthusamy: 29 articles (01/2013 - 08/2003)|
|3.||Oberg, Kjell: 23 articles (06/2013 - 01/2002)|
|4.||Yao, James C: 20 articles (12/2015 - 01/2003)|
|5.||Oberg, K: 18 articles (08/2015 - 01/2000)|
|6.||Kulke, Matthew H: 18 articles (06/2015 - 01/2004)|
|7.||Modlin, Irvin M: 18 articles (12/2014 - 08/2003)|
|8.||Kidd, Mark: 18 articles (12/2014 - 08/2003)|
|9.||Pelosi, Giuseppe: 13 articles (11/2015 - 11/2003)|
|10.||Eriksson, Barbro: 12 articles (01/2015 - 09/2002)|
|1.||Octreotide (Sandostatin)FDA LinkGeneric
10/01/2008 - "Octreotide has proven to be an effective agent for symptoms of carcinoid syndrome. "
12/01/2000 - "Octreotide was initiated, resulting in marked improvement in carcinoid symptoms. "
01/01/1991 - "Complete remission of the tumour by low-dose (2 x 100 micrograms daily) octreotide was observed in one carcinoid patient. "
06/01/2003 - "Short term and long term therapy with octreotide significantly improves survival and reduces the severity of 'carcinoid crises'. "
04/01/1998 - "The response of ECL cell markers in carcinoid tissue to octreotide suggested that these cells were under neuroendocrine control and, therefore, predicted a beneficial outcome for antrectomy. "
|2.||Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
07/01/1996 - "Somatostatin analogues are effective in the sympatomatic treatment of most (metastatic) pancreatic islet cell tumours and most (metastatic) carcinoids. "
04/01/1997 - "The use of long-acting and potent somatostatin analogues is a major advance in the management of carcinoid tumours. "
02/01/1988 - "Somatostatin 201-995 is very effective in treating the syndrome and in preventing carcinoid crisis and has the advantage of producing virtually no significant side effects."
01/01/2002 - "As far as we known, this is the first case of a pancreatic carcinoid treated successfully with somatostatin analogues and having a satisfactory prognosis."
07/01/1988 - "Recently, somatostatin analogue has been used successfully to treat intraoperative carcinoid crisis. "
|3.||Serotonin (5 Hydroxytryptamine)IBA
09/01/1987 - "Hepatic dearterialization seems to be temporarily effective in relieving carcinoid syndrome symptoms and in reducing hormonally active tumour mass and serotonin formation."
05/02/1987 - "Remission of symptoms in carcinoid syndrome with a new 5-hydroxytryptamine M receptor antagonist."
04/01/1992 - "Improved diagnosis of carcinoid tumors by measurement of platelet serotonin."
05/01/1986 - "Evidently, measurement of urinary serotonin excretion is helpful in the evaluation of patients with suspected carcinoid tumors."
06/01/2012 - "In conclusion, the current study in a unique group of untreated carcinoid patients could not demonstrate a major role for circulating serotonin in the control of bone metabolism."
01/01/1992 - "It is concluded that low dose interferon alpha-2b (3 x 10(6) IU) three times weekly is as effective as higher dosages of interferon alpha-2b at ameliorating symptoms of the carcinoid syndrome."
01/01/1991 - "We conclude that interferon is an effective treatment of malignant metastatic midgut carcinoid and that survival might be prolonged compared with historical controls. "
09/01/1989 - "We conclude that interferon seems to be an effective treatment of malignant metastatic midgut carcinoid tumours and that embolization of the liver arteries seems to increase the response rate, as judged after 1 year."
01/01/1989 - "We conclude that interferon is an effective treatment of malignant metastatic midgut carcinoid and that embolization of the liver arteries seems to increase the response rate."
01/01/1992 - "The efficacy of interferon alpha-2b in doses up to 12 x 10(6) IU three times weekly was studied in 21 patients with a metastatic carcinoid tumour. "
06/01/2012 - "Everolimus is associated with a trend toward improved progression-free survival in patients with progressive carcinoid, but is not approved for this indication. "
09/01/2012 - "While mTOR inhibitors, such as everolimus, are established therapy in pancreatic NEN, results from recent clinical trials indicate that mTOR inhibitors may be also of value in the management of carcinoids. "
09/01/2014 - "The activity of everolimus remains under investigation in patients with carcinoid tumors. "
01/01/2013 - "The activity of everolimus, an mTOR inhibitor, has been shown in pancreatic NET but not reported in type 3 gastric carcinoid tumors. "
01/01/2011 - "Control of carcinoid syndrome with everolimus."
08/01/1992 - "Previous studies using immunohistochemistry have shown variable hormone production by carcinoid tumours of the appendix. "
04/01/1990 - "The aim of this study was to establish an experimental model where carcinoid tumours could be maintained and their hormone secretion studied. "
10/01/1986 - "[A study of malignancy in gastro-intestinal carcinoids with special reference to the association of the prognosis and peptide hormone or oncofetal protein producing pattern]."
08/01/1984 - "Amine and peptide hormone production by lung carcinoid: a clinicopathological and immunocytochemical study."
01/01/2014 - "However, some reports also described a correlation to carcinoid tumors, probably triggered via the excessive release of hormones. "
|7.||Fluorouracil (Carac)FDA LinkGeneric
02/01/1996 - "A pilot study of combination therapy with interferon-alpha-2a and 5-fluorouracil in metastatic carcinoid and malignant endocrine pancreatic tumours."
08/01/1994 - "5-Fluorouracil (5-FU) has shown modest single-agent activity in patients with carcinoid or islet cell tumors. "
08/01/1994 - "Twenty-one patients with advanced neuro-endocrine tumors (14 with carcinoid tumors, 7 with islet cell carcinomas) were treated with alpha-IFN and 5-FU in a Phase II study. "
02/01/1984 - "Isolated hyperthermic liver perfusion at 40 degrees C with an average dosage of 1000 mg 5-FU was performed in 32 patients with liver metastases (29 colorectal carcinomas, 2 carcinoids, 1 primary hepatoma). "
03/01/2013 - "This regimen was based on our studies with carcinoid cell lines that showed synergistic cytotoxicity with sequence-specific dosing of 5-fluorouracil preceding temozolomide (TMZ). "
|8.||lanreotide (Somatuline)FDA Link
01/01/2004 - "Rapid and sustained relief from the symptoms of carcinoid syndrome: results from an open 6-month study of the 28-day prolonged-release formulation of lanreotide."
09/01/1998 - "In conclusion, prolonged release lanreotide induced clinical and biochemical remission in this patient with diffusely metastatic GHRH-producing carcinoid. "
01/01/2004 - "This 6-month, open, non-controlled, multicenter, dose-titration study evaluated the efficacy and safety of 28-day prolonged-release (PR) lanreotide in the treatment of carcinoid syndrome. "
01/01/2014 - "Here, we present a case of poorly differentiated, grade 3 pancreatic NEC associated with carcinoid syndrome, for which adequate symptom control was achieved for 2 years and 4 months using the long-acting SSA lanreotide Autogel(®). "
11/01/2000 - "Lanreotide is safe and well tolerated in patients with carcinoid tumors. "
|9.||Adrenocorticotropic Hormone (ACTH)FDA Link
08/01/2010 - "In this study, seven patients with ACTH producing thymic carcinoids were enrolled. "
12/01/2009 - "This study was designed to gain insights into the molecular networks underlying the tumorigenesis of thymic carcinoids with ACTH secretion. "
01/01/2006 - "This study was aimed at understanding the transcription mechanisms of the ACTH-precursor gene in carcinoid tumours of the lung or thymus. "
02/01/2002 - "Histological, immunohistochemical, and ultrastructural studies revealed an ACTH-producing spindle cell carcinoid tumour harbouring pigmented melanocytes. "
07/01/1998 - "Histopathologic studies were consistent with the diagnosis of thymic carcinoid and did not stain for ACTH. "
|10.||pentetreotide (OctreoScan)FDA Link
01/01/1999 - "We conclude that: 1. the octreoscan scintigraphy in the follow-up of resected carcinoids can give false-positive results and 2. in consequence, the mediastinoscopy is a discriminating investigation in case of mediastinal lymph nodes disease."
02/01/2013 - "The scintigraphic investigation of neuroendocrine tumours such as carcinoids has depended on standard techniques such as I-metaiodobenzylguanidine and In-pentetreotide imaging. "
10/01/2010 - "The bronchial biopsy confirmed that it was a typical bronchial carcinoid and the octreoscan showed a single focus of high uptake coinciding with this lesion. "
09/01/2008 - "This case illustrates that hardware SPECT/CT fusion imaging utilizing indium-111 pentetreotide to evaluate metastatic carcinoid tumors can be useful. "
06/01/2007 - "Follow-up of a carcinoid tumor in the middle ear by in-111 pentetreotide scintigraphy."
|1.||Drug Therapy (Chemotherapy)
01/01/2013 - "We present the case of a patient with metastatic goblet cell carcinoid involving terminal ileum, ascendent colon, ovary, omentum and peritoneal spreading, treated with debulking surgery and chemotherapy (FOLFOX4 regimen) with good response, reduction of disease on CT and PET complete remission. "
06/01/1989 - "The management of carcinoid crisis and the results of recent chemotherapy trials are also discussed."
11/01/2014 - "These results support our previous finding that a subset of pulmonary carcinoid tumors are responsive to chemotherapy."
11/01/2014 - "Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors."
08/01/2013 - "Several chemotherapy combinations and IFN-α have been used for the treatment of unresectable carcinoid tumors over the last decades, but they have shown variable clinical results. "
06/01/2013 - "The objective of the present study was to compare the therapeutic efficacy and safety of endoscopic submucosal resection with a ligation device (ESMR-L) with endoscopic submucosal dissection (ESD) for rectal carcinoid tumors. "
09/14/2015 - "Band ligation was effective in resecting the duodenal carcinoid tumor after CMI, with an uneventful post-procedural course. "
02/01/2008 - "Endoscopic submucosal resection with a ligation device is an effective and safe treatment for carcinoid tumors in the lower rectum."
11/01/2012 - "The aim of our study is to evaluate the efficacy of endoscopic mucosal resection with a ligation device (EMR-L) compared to ESD for rectal carcinoid tumors. "
05/01/2012 - "Efficacy of endoscopic submucosal resection with a ligation device for removing small rectal carcinoid tumor compared with endoscopic mucosal resection: analysis of 100 cases."
05/01/1995 - "However, the symptoms of two thymic carcinoid patients had not been relieved at all until radiotherapy was given. "
03/15/1995 - "The purpose of this study was to analyze the effectiveness of radiotherapy for symptomatic, metastatic, and/or unresectable carcinoid tumors. "
05/01/2015 - "Postoperative radiotherapy did not result in better DSS in atypical carcinoid. "
05/01/2015 - "Patients with an atypical carcinoid treated with surgery had better DSS than those treated with radiotherapy (60% vs 54%; p = .035). "
03/01/2015 - "Stereotactic radiotherapy in the treatment of primary bronchial carcinoid tumor."
01/01/2005 - "Renal carcinoid tumors should be managed by radical or partial nephrectomy, and good outcomes have been obtained for organ-confined disease after radical excision. "
01/01/2013 - "Immunohistochemical staining of the nephrectomy specimen helped in the diagnosis of atypical renal carcinoid. "
09/01/2013 - "We report a primary renal carcinoid in a 26-year-old man treated by radical nephrectomy. "
04/01/2010 - "The patient underwent an uneventful right radical nephrectomy, and histological appearance was typical of carcinoid tumor. "
03/01/2006 - "We describe a patient with a primary renal carcinoid tumor successfully treated with laparoscopic partial nephrectomy. "
|5.||Cryotherapy (Therapy, Cold)
07/01/2014 - "Cryotherapy probe biopsy should be considered a safe and effective approach to diagnose carcinoid tumors."
11/01/2006 - "Cryotherapy is a safe and effective adjunct to endobronchial mechanical resection of typical carcinoids. "
05/01/1998 - "Hepatic cryotherapy can provide symptomatic relief for patients with hepatic metastates producing the carcinoid syndrome."
11/01/2006 - "Bronchoscopic cryotherapy treatment of isolated endoluminal typical carcinoid tumor."
05/01/1998 - "To describe the use of hepatic cryotherapy to treat patients with symptomatic carcinoid metastates. "