|1.||Potter, Philip M: 4 articles (12/2013 - 06/2006)|
|2.||Wheelock, Craig E: 3 articles (01/2009 - 07/2005)|
|3.||Wu, Lili: 2 articles (01/2015 - 09/2014)|
|4.||Yang, Jian: 2 articles (01/2015 - 09/2014)|
|5.||Chen, Ruini: 2 articles (01/2015 - 09/2014)|
|6.||Liu, Wei: 2 articles (01/2015 - 09/2014)|
|7.||Hu, Gang: 2 articles (01/2015 - 09/2014)|
|8.||Ning, Rui: 2 articles (01/2015 - 09/2014)|
|9.||Xiong, Jing: 2 articles (01/2015 - 09/2014)|
|10.||Hammock, Bruce D: 2 articles (02/2008 - 07/2005)|
12/21/2012 - "Subsequently, targeted isolation and analysis of single tumor cells were demonstrated by using artificial complex cell samples at simulated conditions, and various cellular carboxylesterases were studied by time-course measurements of cellular fluorescence kinetics at individual-cell level. "
06/01/2002 - "These tumors were believed to arise from the intracellular metabolism of VA by carboxylesterases to cytotoxic and genotoxic compounds. "
01/01/2013 - "Carboxylesterases are important enzymes for xenobiotic metabolism and are receiving increasing attention in the context of cancer therapies. "
03/16/2007 - "Several mammalian carboxylesterases were shown to activate the prodrug irinotecan (CPT-11) to produce 7-ethyl-10-hydroxycamptothecin (SN-38), a topoisomerase inhibitor used in cancer therapy. "
09/01/2006 - "As a consequence, overexpression of carboxylesterases within tumor cells sensitizes these cells to CPT-11. "
|3.||Vitamin A Deficiency
11/01/2012 - "Inhibitory tests recognized EST-1, EST-2 and EST-3 as Acetylcholinesterases (AchEs), EST-4 and EST-5 as Carboxylesterases (CaEs). "
10/01/2012 - "Olive pollen esterases belong to four different functional groups: carboxylesterases, acetylesterases, AChEs and lipases. "
09/01/2009 - "O-aryl carbamate FAAH inhibitors such as URB597 are being evaluated clinically for the treatment of pain and anxiety, but interactions with carboxylesterases in liver might limit their usefulness. "
12/06/1999 - "Organophosphate (OP) compounds such as the nerve agents sarin, soman and VX are powerful inhibitors of acetylcholinesterases (AChEs), butyrylcholinesterases (BChEs), and carboxylesterases (CaEs) The acute toxicity of OPs is the result of their irreversible binding with AChEs in the nervous system, which elevates the acetylcholine (ACh) levels. "
|5.||Colorectal Neoplasms (Colorectal Cancer)
04/01/2002 - "Irinotecan is considered as a prodrug which needs to be activated to SN-38 by carboxylesterases to become able to interact with its target, topoisomerase I. The work reported here intended to identify the determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines, LoVo and HT-29, at the level of the target of the drug and at the level of the availability of the active metabolite to the target. "
05/01/1999 - "CPT-11 is a prodrug activated by carboxylesterases to the active metabolite SN-38 which is a potent inhibitor of topoisomerase I. CPT-11 is of clinical interest in the treatment of colorectal cancer. "
|3.||Carboxylesterase (Hydrolase S)
|4.||Type I DNA Topoisomerases (Topoisomerase I)
|7.||O-(glucuronic acid 2-sulfate)-(1--3)-O-(2,5)-andydrotalitol 6-sulfate
|10.||Lipase (Acid Lipase)
|1.||Drug Therapy (Chemotherapy)