Carbocysteine (S-Carboxymethylcysteine)

A compound formed when iodoacetic acid reacts with sulfhydryl groups in proteins. It has been used as an anti-infective nasal spray with mucolytic and expectorant action.

Also Known As:

S-Carboxymethylcysteine; 3-(Carboxymethylthio)alanine; Carbocysteine, L-Isomer; Mucodine; Mucodyne; Mukodin; Rhinathiol; S-(Carboxymethyl)-L-cysteine; Thiodril; Carbocysteine, L Isomer; L-Isomer Carbocysteine; S Carboxymethylcysteine; Cysteine, S-(carboxymethyl)-

Networked: 101 relevant articles (19 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Steventon, Glyn B: 8 articles (04/2019 - 12/2004)
2.	Mitchell, Stephen C: 7 articles (04/2019 - 11/2006)
3.	Lanata, Luigi: 5 articles (06/2022 - 11/2013)
4.	Pace, Elisabetta: 5 articles (06/2022 - 11/2013)
5.	Di Vincenzo, Serena: 4 articles (02/2022 - 11/2013)
6.	Ferraro, Maria: 4 articles (02/2022 - 11/2013)
7.	Gerbino, Stefania: 3 articles (03/2014 - 11/2013)
8.	Gjomarkaj, Mark: 3 articles (03/2014 - 11/2013)
9.	Chalumeau, Martin: 3 articles (05/2013 - 01/2009)
10.	Allegretti, Marcello: 2 articles (06/2022 - 10/2021)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 10/01/2010 - "These results suggest that carbocysteine may be beneficial in patients with COPD by increasing the clearance of bacteria and decreasing bacterial load." 06/14/2022 - "This analysis demonstrates that the use of carbocysteine in COPD patients represents a well-tolerated treatment with a favorable safety profile, and might contribute to a better quality of life for patients suffering from this serious illness." 03/01/2009 - "Carbocysteine has been recently recognized as an effective and safe treatment for the long-term management of COPD, able to reduce the incidence of exacerbations and improve patient quality of life. " 10/01/2010 - "Several clinical trials have indicated that carbocysteine reduces exacerbation rates in COPD. " 02/19/2010 - "The aim of this study was to investigate the feasibility of employing S-carboxymethyl-L-cysteine as a treatment of chronic obstructive pulmonary disease in dogs. "
2.	Otitis Media with Effusion 05/01/2006 - "Efficacy of S-carboxymethyl-L-cysteine for otitis media with effusion." 07/01/1994 - "Effect of S-carboxymethylcysteine on the clearance of middle ear effusion. " 01/01/2001 - "Studies were randomised, double-blind comparisons of S-carboxymethylcysteine (any dose and duration) with placebo in otitis media with effusion. " 08/01/2000 - "A recent meta-analysis suggested a possible beneficial effect of carboxymethylcysteine (Mucodyne) in resolving otitis media with effusion (OME), but the methodology in several of the included trials was flawed. " 08/01/2000 - "The role of Mucodyne in reducing the need for surgery in patients with persistent otitis media with effusion."
3.	Inflammation (Inflammations) 02/11/2022 - "The present study provides compelling evidence that carbocysteine may help to manage mild AECOPD by downregulating some parameters of systemic inflammation." 10/01/2005 - "In conclusion, the data indicate that S-carboxymethylcysteine is effective in reducing airway hyperresponsiveness and airway inflammation at two distinct phases of the response to the secondary allergen challenge in sensitised mice." 07/01/2010 - "The combination of two agents, montelukast and S-carbocysteine, demonstrated additive effects on AHR and airway inflammation in a secondary allergen model most likely through independent mechanisms of action." 08/01/2004 - "Reduced airway inflammation and remodeling in parallel with mucin 5AC protein expression decreased by s-carboxymethylcysteine, a mucoregulant, in the airways of rats exposed to sulfur dioxide." 07/01/2010 - "Effects of combination therapy with montelukast and carbocysteine in allergen-induced airway hyperresponsiveness and airway inflammation."
4.	Obstructive Lung Diseases (Obstructive Lung Disease) 01/01/2008 - "The role for S-carboxymethylcysteine (carbocisteine) in the management of chronic obstructive pulmonary disease." 02/19/2010 - "All these results indicate that the oral administration of S-carboxymethyl-L-cysteine may be useful during the therapeutic management of chronic obstructive pulmonary disease in dogs."
5.	Bronchitis 09/01/1992 - "The results of the examination revealed the more favourable effect of carbocysteine, as compared with a mixture of Ipeca syrup in the treatment of acute relapsing bronchitis in infants." 09/01/1992 - "[Carbocysteine in the treatment of recurrent bronchitis in infants]." 01/01/1992 - "Study on the effect of oral administration of carbocysteine on ventilatory parameters in the SO2 inhalation model of bronchitis in the rat." 03/15/1979 - "[Changes in sputum in catarrhal bronchitis in children after treatment with S-carboxymethylcysteine (viscosimetric studies)]." 12/01/1975 - "The mucolytic efficacy of S-carboxymethylcysteine has been assessed in a double-blind crossover trial in 16 patients with chronic obstructive bronchitis. "

Related Drugs and Biologics

1.	Expectorants (Mucolytics)
2.	Antioxidants
3.	erdosteine
4.	sobrerol
5.	Ambroxol (Mucosolvan)
6.	Clarithromycin (Biaxin)
7.	Allergens
8.	Oxygen (Dioxygen)
9.	Acetylcysteine (Siran)
10.	Carbocysteine (S-Carboxymethylcysteine)

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	Aftercare (After-Treatment)