Chronic Mucocutaneous Candidiasis

A clinical syndrome characterized by development, usually in infancy or childhood, of a chronic, often widespread candidiasis of skin, nails, and mucous membranes. It may be secondary to one of the immunodeficiency syndromes, inherited as an autosomal recessive trait, or associated with defects in cell-mediated immunity, endocrine disorders, dental stomatitis, or malignancy.
Also Known As:
Candidiasis, Chronic Mucocutaneous; Candidiases, Chronic Mucocutaneous; Chronic Mucocutaneous Candidiases; Mucocutaneous Candidiases, Chronic; Mucocutaneous Candidiasis, Chronic
Networked: 195 relevant articles (12 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Infection
2. Candidiasis (Moniliasis)
3. Acquired Immunodeficiency Syndrome (AIDS)
4. IgA Deficiency
5. Histoplasmosis


1. Casanova, Jean-Laurent: 12 articles (04/2014 - 02/2010)
2. Puel, Anne: 9 articles (04/2014 - 02/2010)
3. Lilic, Desa: 8 articles (10/2015 - 04/2002)
4. Cypowyj, Sophie: 8 articles (04/2014 - 04/2011)
5. Picard, Capucine: 8 articles (12/2013 - 02/2010)
6. Abel, Laurent: 6 articles (10/2013 - 02/2010)
7. Maródi, László: 5 articles (02/2014 - 08/2011)
8. Bustamante, Jacinta: 5 articles (12/2013 - 02/2010)
9. Al-Muhsen, Saleh: 5 articles (03/2013 - 02/2010)
10. Netea, Mihai G: 4 articles (10/2015 - 12/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Mucocutaneous Candidiasis:
1. Ketoconazole (Nizoral)FDA LinkGeneric
2. Interleukin-17 (Interleukin 27)IBA
3. CytokinesIBA
4. Transfer Factor (Factor, Transfer)IBA
5. Interleukin-10 (Interleukin 10)IBA
6. Itraconazole (Sporanox)FDA LinkGeneric
7. Cimetidine (Biomet)FDA LinkGeneric
8. Granulocyte Colony-Stimulating Factor (G-CSF)IBA
9. Systemic candidiasisIBA
08/01/2013 - " newborn eczematous eruption, which occurs mainly in the signal-transducer-and-activator-of-transcription-3 (STAT3) variant, helps to differentiate STAT3 from Dedicator of Cytokinesis 8-related Hyper-IgE-syndrome (HIES).Impaired T helper 17 cell (TH17) immunity [HIES and defects of autoimmune regulator element (AIRE), STAT-1, and interleukin17 receptor(IL17(R))] may give rise to localized chronic mucocutaneous candidiasis, whereas a defective innate immune system predisposes to systemic candidiasis [congenital neutropenia, neutrophil dysfunction, and caspase recruitment domain 9 (CARD9) deficiency].Noninfectious granulomas may be the presenting symptom in innate immunity defects [such as chronic granulomatous disease (CGD) or in predominantly humoral immunodeficiencies such as common variable immunodeficiency], as well as ataxia teleangiectasia or rare recombination-activating gene-deficient cases. "
01/24/1983 - "Excellent results were obtained in six cases of chronic mucocutaneous candidiasis, with restoration of immunologic disturbances; 23 cases of systemic candidiasis, including new aspects of heroin addicts with cutaneous, ocular, or osteoarticular manifestations; eight cases of histoplasmosis, five due to Histoplasma capsulatum and three to Histoplasma duboisii, with cure in seven and remission in one; one case of African blastomycosis (Blastomyces dermatitidis); three cases of mycetoma, two due to Monosporium apiospermum, one due to a dematiacious fungus; three cases of entomophthoromycosis with cure; one case of fungal arthritis, due to new hyphomycete similar to M. "
10. ZincIBA

Therapies and Procedures

1. Immunotherapy
2. Transplantation (Transplant Recipients)
3. Bone Marrow Transplantation (Transplantation, Bone Marrow)
4. Vertical Dimension (Occlusion Vertical Dimension)
5. Radiotherapy