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Calpain

Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
Also Known As:
Ca2+-Activated Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Neutral Protease; Calpain I; Calpain II; Desminase; Ca2+ Activated Protease; Calcium Activated Neutral Protease; Calcium Activated Neutral Proteinase; Calcium Activated Protease; Calcium Dependent Neutral Protease; Calcium Dependent Neutral Proteinase; I, Calpain; II, Calpain; Neutral Protease, Calcium-Activated; Neutral Protease, Calcium-Dependent; Neutral Proteinase, Calcium-Activated; Neutral Proteinase, Calcium-Dependent; Protease, Ca2+-Activated; Protease, Calcium-Activated; Protease, Calcium-Activated Neutral; Protease, Calcium-Dependent Neutral; Proteinase, Calcium-Activated Neutral; Proteinase, Calcium-Dependent Neutral; Calcium-Activated Neutral Protease; Calcium-Dependent Neutral Proteinase
Networked: 1539 relevant articles (40 outcomes, 209 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Banik, Naren L: 28 articles (10/2015 - 06/2002)
2. Ray, Swapan K: 25 articles (11/2012 - 06/2002)
3. Azuma, Mitsuyoshi: 16 articles (09/2015 - 02/2002)
4. Wang, Kevin K W: 15 articles (09/2014 - 12/2005)
5. Shearer, Thomas R: 14 articles (09/2015 - 02/2002)
6. Saido, Takaomi C: 14 articles (01/2015 - 01/2003)
7. Sorimachi, Hiroyuki: 14 articles (08/2013 - 07/2003)
8. Banik, N L: 13 articles (09/2009 - 01/2000)
9. Greer, Peter A: 12 articles (01/2016 - 06/2006)
10. Hayes, Ronald L: 12 articles (03/2014 - 01/2004)

Related Diseases

1. Ischemia
2. Brain Injuries (Brain Injury)
3. Anoxia (Hypoxia)
4. Neoplasms (Cancer)
5. Necrosis

Related Drugs and Biologics

1. calpain inhibitors
2. Caspase 3 (Caspase-3)
3. calpeptin
4. Calcium
5. Proteins (Proteins, Gene)
6. calpain inhibitor III
7. Spectrin
8. Cysteine Proteases (Cysteine Protease)
9. Proteasome Endopeptidase Complex (Proteasome)
10. Ubiquitin

Related Therapies and Procedures

1. Lenses
2. Drug Therapy (Chemotherapy)
3. Ischemic Postconditioning
4. Protein-Restricted Diet (Diet, Protein Restricted)
5. Mechanical Ventilators (Ventilator)