Calciphylaxis

Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.

Also Known As:

Calciphylaxes; Idiopathic Calciphylaxis; Arteriolopathy, Calcific Uraemic; Calcific Uraemic Arteriolopathies; Calciphylaxis, Idiopathic; Uraemic Arteriolopathy, Calcific; Calcific Uraemic Arteriolopathy

Networked: 730 relevant articles (59 outcomes, 40 trials/studies)

Relationship Network

Disease Context: Research Results

Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Calcium Metabolism Disorders: 47
    - Calcinosis: 1855
      - Calciphylaxis: 730

Related Diseases

1.	Wounds and Injuries (Trauma)
2.	Chronic Kidney Failure (Chronic Renal Failure)
3.	Pain (Aches)
4.	Chronic Renal Insufficiency
5.	Skin Ulcer

Experts

1.	Nigwekar, Sagar U: 19 articles (01/2022 - 07/2008)
2.	Kroshinsky, Daniela: 10 articles (11/2021 - 07/2013)
3.	Cozzolino, Mario: 8 articles (06/2022 - 11/2011)
4.	Liu, Yuqiu: 6 articles (12/2022 - 01/2020)
5.	Sinha, Smeeta: 6 articles (01/2022 - 12/2014)
6.	Brandenburg, Vincent M: 6 articles (10/2020 - 01/2008)
7.	Zhang, Xiaoliang: 5 articles (12/2022 - 01/2021)
8.	Perelló, Joan: 5 articles (01/2022 - 01/2018)
9.	Nazarian, Rosalynn M: 5 articles (01/2019 - 07/2014)
10.	Davis, Mark D P: 5 articles (10/2017 - 09/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Calciphylaxis:

1.	sodium thiosulfate FDA Link 08/01/2013 - "Sodium thiosulfate (STS), which has been proven to be effective in the treatment of uremic calciphylaxis, shows promise; however, reports of its use in non-uremic cases are limited. " 05/01/2012 - "Intravenous sodium thiosulfate has been used successfully to treat renal and normo-renal calciphylaxis. " 12/01/2020 - "Sodium thiosulfate has been used for more than a decade in the treatment of uremic calciphylaxis and has been shown to be effective. " 01/01/2023 - "Sodium thiosulfate (STS) is effective for calciphylaxis in dialysis patients; however, the influence of STS on CAC in dialysis patients remains unclear. " 08/01/2013 - "Intralesional sodium thiosulfate may be an effective and well-tolerated treatment for localized calciphylaxis. "
2.	SodiumIBA 07/01/2023 - "Here were present a case of 74-year-old male who presented with penile calciphylaxis and was treated successfully with oral sodium thiosulphate." 08/01/2016 - "Treatment with sodium thiosulphate has shown promising results, and there is thus a need to improve the recognition of calciphylaxis." 06/01/2013 - "Sodium thiosulphate can be a safe and effective treatment option for resistant and severe cases of calciphylaxis." 11/01/2009 - "We herewith report a case of calciphylaxis that was cured using intravenous sodium thiosulphate treatment." 01/01/2023 - "Sodium thiosulphate (STS) has been used as an off-label therapeutic in calciphylaxis, but there is a lack of clinical trials and studies that demonstrate its effect compared with those without STS treatment. "
3.	Warfarin (Coumadin)FDA LinkGeneric 05/01/2018 - "Though this study is limited by its retrospective nature and the relatively small number of patients studied, available data do not support subclassifying patients with nonuremic calciphylaxis as having warfarin-associated or warfarin-unassociated disease. " 09/01/2023 - "This paper highlights the possible importance of warfarin being an inciting event, as well as the early differentiation between the presentations of WISN and calciphylaxis." 05/02/2023 - "Penile calciphylaxis in a patient with concurrent haemodialysis and Coumadin treatment." 03/01/2023 - "We present a case report highlighting a 47-year-old woman who developed warfarin-induced calciphylaxis. " 01/01/2022 - "In this report, we describe the evaluation and treatment of a 75-year-old female patient with warfarin-induced calciphylaxis who presented unique symptoms. "
4.	Cinacalcet (Sensipar)FDA Link 01/01/2008 - "Cinacalcet as first-line treatment for calciphylaxis." 08/01/2019 - "Additional research needs to be performed in this area, to further define the optimal use of cinacalcet for the treatment of calciphylaxis." 01/01/2011 - "It also supports other authors' findings that cinacalcet may be an important adjunct in the treatment of calciphylaxis." 01/01/2011 - "It was only after initiating cinacalcet that the patient experienced complete wound healing and resolution of her calciphylaxis. " 01/01/2008 - "We present a case of severe proximal calciphylaxis treated with a small dose of the calcimimetic 'Cinacalcet'."
5.	SNF472IBA 01/01/2019 - "SNF472 is a calcification inhibitor that is being studied as a novel treatment for calciphylaxis and cardiovascular calcification (CVC). " 01/01/2022 - "Those results informed the design of the CALCIPHYX trial, an ongoing, randomized, placebo-controlled, Phase 3 trial of SNF472 for treatment of calciphylaxis. " 01/01/2022 - "The CALCIPHYX study: a randomized, double-blind, placebo-controlled, Phase 3 clinical trial of SNF472 for the treatment of calciphylaxis." 10/01/2019 - "A randomized, double-blind, placebo-controlled trial is planned to evaluate SNF472 in patients with calciphylaxis." 01/01/2022 - "This randomized, placebo-controlled Phase 3 clinical trial will examine the efficacy and safety of SNF472 in patients who have ulcerated calciphylaxis lesions. "
6.	Phosphates (Orthophosphate)IBA 11/01/2001 - "Both coronary artery calcification and calciphylaxis are prototypical examples of arterial calcification that have been associated with poor phosphate control. " 07/01/2001 - "There was a 3.51-fold increase in the risk of calciphylaxis associated with each mg/dL increase in the mean serum phosphate during the year prior to diagnosis (95% CI, 0.99 to 12.5, P = 0.052). " 10/28/2011 - "Initial histological findings were consistent with the clinical diagnosis of calciphylaxis and supportive treatment was commenced with addition of a phosphate binder and dietary restriction. " 06/01/2014 - "Severe nonuremic calciphylaxis due to hyperphosphatemia resolving with multimodality treatment including phosphate binders." 09/01/2022 - "Calciphylaxis is the deposition of calcium and phosphate into arteriolar walls caused by exceeding their solubility range in the blood. "
7.	Diphosphonates (Bisphosphonates)IBA 12/01/2020 - "Successful treatment of non-uremic calciphylaxis with bisphosphonate." 05/14/2012 - "Successful treatment of calcific uraemic arteriolopathy with bisphosphonates." 04/01/2005 - "Amino bisphosphonates, have shown to completely inhibit soft tissue calcifications, calciphylaxis and prevent death in animal models. " 06/28/1977 - "The effects of various diphosphonates on a rat model of cardiac calciphylaxis." 12/01/2007 - "Bisphosphonates may be effective in treating calciphylaxis and arteriosclerosis obliterans by reducing the formation of ectopic calcification around blood vessels."
8.	Vitamin D FDA LinkGeneric 09/01/2023 - "Calciphylaxis Secondary to Vitamin D Supplementation." 01/01/2016 - "Nevertheless, other non-negligible risk factors for calciphylaxis such as alcoholic liver disease, obesity, and vitamin D treatment must also be considered in this patient. " 06/01/2008 - "Vitamin D analogs remain the primary therapy for secondary hyperparathyroidism, although the use of the less hypercalcemic agents is preferred due to concerns of calciphylaxis and vascular calcification. " 10/01/2002 - "In the present experiments we have examined the effect of ibandronate on an entirely different type of calcification, the calciphylaxis induced by administration of a challenger to rats previously treated with sub-lethal doses of vitamin D. " 06/01/1996 - "The calcification-prone state, known as calciphylaxis, was induced in 4-week old rats by oral administration of a vitamin-D analog, dihydrotachysterol. "
9.	AntacidsIBA 10/01/2003 - "Treatment with phosphate-binding antacids, total or partial parathyroidectomy, and avoidance of local tissue trauma remain the mainstays of therapy, although a uniform cure for calciphylaxis remains elusive. " 02/01/1994 - "Although treatment with phosphate-binding antacids, total or subtotal parathyroidectomy, and avoidance of challengers such as Vitamin D or local tissue trauma remain the mainstays of therapy, the uniform cure for calciphylaxis remains elusive. "
10.	lanthanum carbonate (Fosrenol)FDA Link 05/14/2014 - "The aim of this pilot study is to determine if lanthanum carbonate is effective in inducing remission of calciphylaxis lesions and demonstrate an improved DLQI (Dermatology Life Quality Index). " 05/14/2014 - "Pilot Study of the Effect of Lanthanum Carbonate (Fosrenol®) In Patients with Calciphylaxis: A Wisconsin Network for Health Research (WiNHR) Study." 05/14/2014 - "Lanthanum carbonate appears to be efficacious as an adjunctive therapy to improve calciphylaxis lesions and symptom burden. " 11/01/2008 - "Calciphylaxis responsive to lanthanum carbonate (FOSRENOL) therapy." 01/01/2003 - "Although not yet extensively used in pediatric patients with secondary hyperparathyroidism, several therapeutic alternatives, such as the less calcemic vitamin D analogs, including paricalcitol [19-nor-1,25-(OH)(2)D(2)] and doxercalciferol [1-alpha-(OH)(2)D(2)], calcimimetics, and the availability of a calcium-free, aluminum-free phosphate binder such as sevelamer hydrochloride and lanthanum carbonate, may play significant roles in the future management of children with secondary hyperparathyroidism to promote linear growth, prevent parathyroid gland hyperplasia, avoid calciphylaxis and, in the long run, avert vascular calcifications."

Therapies and Procedures

1.	Therapeutics 08/01/2017 - "Two of the five patients were identified early to have calciphylaxis and were promptly initiated on aggressive, multimodal therapy, resulting in complete resolution and remission of calciphylaxis. " 08/01/2013 - "Based on the successful outcomes detailed in this case series, STS appears to be an effective therapy for non-uremic calciphylaxis. " 01/01/2012 - "Calcific uremic arteriolopathy (CUA) or calciphylaxis though generally noted for its high mortality, recent case reports have shown promising results using single agent therapies. " 11/01/2023 - "This study focuses on the application of nurse-led multidisciplinary collaborative therapy (MDT) management model for calciphylaxis prevention of patients with terminal renal disease. " 01/01/2019 - "This review highlights ongoing clinical trials studying therapeutic options in calciphylaxis and emphasizes the causal pathways that led to the development of such therapies."
2.	Parathyroidectomy 10/01/2017 - "Even though parathyroidectomy is an effective treatment for calciphylaxis, clinicians should be aware that it can rarely present after parathyroidectomy." 04/01/2000 - "This study evaluates the success of parathyroidectomy in reversing the ill effects of calciphylaxis in both our patient population and the literature. " 08/01/2023 - "We present a case of a young patient who developed calciphylaxis after parathyroidectomy, an uncommon presentation." 08/01/2023 - "Calciphylaxis after parathyroidectomy is a rare presentation. " 01/01/2023 - "Successful treatment of severe calciphylaxis in a renal transplant patient with previous total parathyroidectomy."
3.	Renal Dialysis (Hemodialysis) 01/01/2018 - "A New Treatment for Calciphylaxis in Hemodialysis Patients?" 08/01/2014 - "Calciphylaxis incidence continued to rise even after limiting the study period to 2007 onwards (from 3.7 to 5.7 per 10,000 chronic hemodialysis patients; r = 0.91, p = 0.02). " 08/01/2002 - "The outpatient hemodialysis population has a reported calciphylaxis prevalence of 1% to 4.1%; however, published studies contain only a few case reports of penile calciphylaxis. " 12/01/2023 - "Hemodialysis patients with calciphylaxis were matched to hemodialysis patients without calciphylaxis in a 1:2 ratio for age and sex from September 2, 2017 to July 3, 2020. " 12/01/2023 - "Our objectives were to describe risk factors, prevalence, incidence, and outcomes for calciphylaxis in hemodialysis patients within the Fraser Health Renal Program. "
4.	Hyperbaric Oxygenation 07/14/2020 - "Improvement in a few calciphylaxis cases affecting the extremities or abdomen have been reported using hyperbaric oxygen therapy (HBOT), however, very few have had a favorable response when it affected penile tissue. " 06/01/2010 - "No standard treatment has been established for atypical calciphylaxis; however, a potentially beneficial treatment is hyperbaric oxygen therapy (HBOT). " 07/01/2015 - "The aim of this study was to determine whether hyperbaric oxygen therapy (HBOT) is effective in healing calciphylaxis lesions and to determine if there are any patient factors that can predict wound healing and patient survival. " 08/14/2023 - "A retrospective review of outcomes after hyperbaric oxygen therapy for the treatment of calciphylaxis." 07/14/2020 - "Hyperbaric Oxygen Therapy Improving Penile Calciphylaxis."
5.	Limb Salvage 12/01/2004 - "Limb salvage in calciphylaxis, symptomatic relief, and improved bone density are substantial benefits to recommend this procedure to patients with renal hyperparathyroidism." 03/01/2003 - "Early recognition of calciphylaxis and multidisciplinary treatment, including diligent wound care, frequent debridement, parathyroidectomy, and appropriate skin grafting or revascularization, can result in improved wound healing and limb salvage." 06/01/2001 - "Calciphylaxis: a poor prognostic indicator for limb salvage."