Cadaverine

A foul-smelling diamine formed by bacterial DECARBOXYLATION of LYSINE. It is also an intermediate secondary metabolite in lysine-derived alkaloid biosynthetic pathways (e.g., QUINOLIZIDINES and LYCOPODIUM).

Also Known As:

Networked: 100 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Levine, Martin: 2 articles (05/2021 - 05/2008)
2.	Chung, Bong Chul: 2 articles (02/2021 - 11/2019)
3.	Hong, Jongki: 2 articles (02/2021 - 11/2019)
4.	Lee, Yu Ra: 2 articles (02/2021 - 11/2019)
5.	Li, Qing: 2 articles (10/2017 - 02/2013)
6.	Liu, Ran: 2 articles (10/2017 - 02/2013)
7.	Yeoman, Carl J: 2 articles (01/2015 - 01/2013)
8.	Gibbs, Nicole M: 1 article (04/2022)
9.	Masson, Patrick H: 1 article (04/2022)
10.	Su, Shih-Heng: 1 article (04/2022)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 10/24/2017 - "Plasma N-acetylputrescine, cadaverine and 1,3-diaminopropane: potential biomarkers of lung cancer used to evaluate the efficacy of anticancer drugs." 01/01/1983 - "The excretion of spermine, spermidine and cadaverine was increased in lung cancer without metastases. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2019 - "In this study, we assessed the relationship between breast cancer and cadaverine biosynthesis. " 01/01/2019 - "Taken together, cadaverine production seems to be a regulator of early breast cancer." 01/01/2019 - "Cadaverine treatment of breast cancer cell lines corresponding to its serum reference range (100-800 nM) reverted endothelial-to-mesenchymal transition, inhibited cellular movement and invasion, moreover, rendered cells less stem cell-like through reducing mitochondrial oxidation. " 07/17/2020 - "The microbiome synthesizes a set of cytostatic and antimetastatic metabolites that are downregulated in breast cancer, including cadaverine, a microbiome metabolite with cytostatic properties. " 01/01/2019 - "Early stage breast cancer patients, versus control women, had reduced abundance of the CadA and LdcC genes in fecal DNA, both responsible for bacterial cadaverine production. "
3.	Dysbiosis 05/27/2021 - "Cadaverine increases and supports the development of a butyrate-producing microbiome that utilizes the increased GCF substrates to slowly destroy the periodontium (dysbiosis). " 01/01/2015 - "Finally, we show in a small cross sectional study of 37 women that the BAs putrescine, cadaverine and tyramine are significantly higher in CST IV over CSTs I and III. These data support the hypothesis that BA production is conducted by few vaginal taxa and may be important to the outgrowth of BV-associated (vaginal dysbiosis) vaginal bacteria. " 01/01/2022 - "This study revealed the unexpected function of host CYP1A1 in microbiota-mediated cadaverine metabolism, with crucial consequences for dysbacteriosis following MRSA-induced abdominal sepsis, indicating that inhibiting CYP1A1 or blocking cadaverine-histamine H4 receptor signaling could be a potential therapeutic target against abdominal sepsis. "
4.	Sepsis (Septicemia) 01/01/2022 - "This study revealed the unexpected function of host CYP1A1 in microbiota-mediated cadaverine metabolism, with crucial consequences for dysbacteriosis following MRSA-induced abdominal sepsis, indicating that inhibiting CYP1A1 or blocking cadaverine-histamine H4 receptor signaling could be a potential therapeutic target against abdominal sepsis. "
5.	Neoplasms (Cancer) 01/01/2023 - "Next, Cell Counting Kit-8, wound healing assay, flow cytometry, monodansyl cadaverine autophagy staining assay, immunofluorescence staining and western blot, either in the absence or presence of ERBB2/AKT/mTOR inhibitors, were carried out in GBM U87 cell line to explore molecular pathway underlying GBM malignancy. " 02/19/1999 - "Capillary gas chromatographic determination of putrescine and cadaverine in serum of cancer patients using trifluoroacetylacetone as derivatizing reagent." 03/01/1984 - "When tumor-bearing animals were pretreated with DFMO or with DFMO and 5-alpha-dihydrotestosterone propionate, the tumor and prostate uptake of [14C]putrescine and [14C]-cadaverine was enhanced but not substantially increased in other tissues. " 05/21/2021 - "Putrescine and cadaverine are biogenic amines that serve as potential biomarkers for several types of cancers and monitoring food quality. " 07/01/1987 - "The urine levels of polyamine (total amount of putrescine, spermidine and cadaverine) were measured in patients with or without cancer by simple enzymatic assay method. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	N-acetylputrescine (acetylputrescine)
3.	Cytochrome P-450 CYP1A1 (CYP1A1)
4.	Histamine H4 Receptors
5.	Putrescine
6.	Spermidine
7.	Spermine
8.	Polyamines
9.	Histamine (Histamine Dihydrochloride)
10.	Tyramine

Related Therapies and Procedures

1.	Thyroidectomy
2.	Therapeutics
3.	Oral Hygiene (Dental Hygiene)
4.	Renal Dialysis (Hemodialysis)