Byssinosis

A condition of BRONCHOCONSTRICTION resulting from hypersensitive reaction to inhaled dust during the initial processing of cotton, flax, or hemp in the textile industry. Symptoms include wheezing and tightness in the chest.

Also Known As:

Networked: 115 relevant articles (0 outcomes, 23 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Silicosis
2.	Fever (Fevers)
3.	Lung Diseases (Lung Disease)
4.	Poisoning
5.	Immediate Hypersensitivity

Experts

1.	Dutkiewicz, Jacek: 2 articles (12/2020 - 01/2015)
2.	Lemieszek, Marta Kinga: 2 articles (12/2020 - 01/2015)
3.	Mackiewicz, Barbara: 2 articles (12/2020 - 01/2015)
4.	Bertazzi, P A: 2 articles (11/2012 - 01/2003)
5.	Christiani, D C: 2 articles (12/2003 - 03/2001)
6.	Eisen, E A: 2 articles (12/2003 - 03/2001)
7.	Olenchock, S A: 2 articles (12/2003 - 03/2001)
8.	Wegman, D H: 2 articles (12/2003 - 03/2001)
9.	Belingheri, Michael: 1 article (12/2019)
10.	Fustinoni, Silvia: 1 article (12/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Byssinosis:

1.	EndotoxinsIBA 04/21/1997 - "Byssinosis defined as Monday chest tightness and slight dyspnoea in the work place has been related to endotoxin exposure in cotton mills, but studies indicate that similar symptoms may be found in other work places. " 06/01/1994 - "Recent studies have shown a close association between byssinosis and airborne endotoxin concentrations. " 01/01/1992 - "We found a dose-response relationship between endotoxin exposure and byssinosis, and a significant association between A-1-A serum concentrations less than or equal to 35 mumol/liter and byssinosis, a finding we are further evaluating in subsequent studies." 02/01/1985 - "This observation supports findings from several previous studies and suggests that endotoxin triggers the mechanisms responsible for the decrease in respiratory function in the byssinosis syndrome. " 01/01/1978 - "A study on the role of some endotoxins in the aetiology of byssinosis in cotton and flax industries."
2.	AntigensIBA 06/01/1978 - "The authors suggest that further study of the inhaled antigens to which cotton workers are exposed is indicated before discarding immunologic mechanisms to explain the development of byssinosis and other pulmonary disorders to which such workers are subject." 05/01/1979 - "HLA antigen frequencies in flax byssinosis patients." 02/01/1973 - "Pseudoimmune precipitation by the isolated byssinosis "antigen"." 09/19/1964 - "BYSSINOSIS: ANTIBODY TO COTTON ANTIGENS IN NORMAL SUBJECTS AND IN COTTON CARD-ROOM WORKERS." 01/01/1983 - "Preliminary crossed radio-immunoelectrophoretic studies demonstrated that some of these antigens are allergenic in man, suggesting that an IgE-mediated hypersensitivity against cotton dust, or a fungal component of the dust, may be important in byssinosis pathogenesis."
3.	Histamine (Histamine Dihydrochloride)FDA Link 09/01/2001 - "Histamine can cause a severe constriction of the central as well as peripheral airways in cotton dust-exposed workers, enabling a paradoxical effect for a differential diagnosis of byssinosis." 09/01/2001 - "Differential diagnosis of byssinosis by blood histamine and pulmonary function test: a review and an appraisal." 01/01/1989 - "Flax dust-affected histamine reactions were not so distinct: lymphocyte and neutrophil reactivity in byssinosis patients did not exceed the standards. " 01/01/1989 - "[Histamine-related reactions in patients with byssinosis]." 05/01/1984 - "Role of histamine in the aetiology of byssinosis. "
4.	MetalsIBA 12/06/2019 - "Gianmario Cavagna, one of the first Italian toxicologists, contributed to the discovery of the origin of fevers caused by the inhalation of metal fumes and to the studies on the pathogenesis of byssinosis, hypothesizing a role of bacterial endotoxins in the genesis of this disease. " 11/01/2012 - "Afterwards he conducted pioneering studies on occupational oncology (benzene-induced leukaemia, bladder cancer due to aromatic amines, asbestos-related tumours), pathogenesis of silicosis, encephalopathy in carbon disulfide poisoning, byssinosis and metal fume fever, so influencing international research and the implementation of preventive measures against these conditions. " 09/01/2017 - "Nowadays, ND finds many applications: (I) intratumor detection of heavy metals and endocrine metal disruptors; (II) identification of pathogenic nanoparticles in medical or veterinary drugs and devices, cosmetics, household products, and foodstuffs; (III) differential diagnosis of sarcoid-type granulomas (berylliosis, baritosis) and foreign body granulomas (prosthetic, iatrogenic); (IV) attestation of occupational disease correlating the datum with the occupational risk (anthracosis, asbestosis, bauxite fibrosis, byssinosis, chalicosis, siderosis, silicosis, stannosis, talcosis); and (V) forensic investigations to ascertain a causal link between disease and environmental, military, or work exposure. "
5.	Arachidonic Acid (Vitamin F)IBA 08/01/1990 - "Recent studies have indicated that the condensed tannins present in cotton mill dust stimulate the secretion of neutrophil chemotactic factor and arachidonic acid from resident rabbit alveolar macrophages and that these responses may contribute to the acute pulmonary inflammatory reaction associated with byssinosis. " 06/01/1986 - "Studies of etiopathogenic mechanisms of bronchoconstriction in byssinosis indicate the possible involvement of histamine, 5-HT, platelet-activating factor, and metabolites of arachidonic acid as mediators of bronchoconstriction. "
6.	Benzene (Benzole)IBA 01/01/2003 - "We mention here, in particular, the results of the study of "early" markers of lead intoxication; the research on the carcinogenicity of benzene and aromatic amines; the study of the pathogenesis of silicosis and byssinosis; the study of cytogenetic damage after exposure to industrial toxic chemicals; the technical research for dust abatement in mines. " 11/01/2012 - "Afterwards he conducted pioneering studies on occupational oncology (benzene-induced leukaemia, bladder cancer due to aromatic amines, asbestos-related tumours), pathogenesis of silicosis, encephalopathy in carbon disulfide poisoning, byssinosis and metal fume fever, so influencing international research and the implementation of preventive measures against these conditions. "
7.	AminesIBA 01/01/2003 - "We mention here, in particular, the results of the study of "early" markers of lead intoxication; the research on the carcinogenicity of benzene and aromatic amines; the study of the pathogenesis of silicosis and byssinosis; the study of cytogenetic damage after exposure to industrial toxic chemicals; the technical research for dust abatement in mines. " 11/01/2012 - "Afterwards he conducted pioneering studies on occupational oncology (benzene-induced leukaemia, bladder cancer due to aromatic amines, asbestos-related tumours), pathogenesis of silicosis, encephalopathy in carbon disulfide poisoning, byssinosis and metal fume fever, so influencing international research and the implementation of preventive measures against these conditions. "
8.	TanninsIBA 01/01/2002 - "Tannins also have an effect on humans: They are, for example, the cause of byssinosis, a condition that is due to exposure to airborne tannin. " 01/01/1988 - "A role for tannin as a polyclonal cell activator and, therefore, a possible etiologic agent of byssinosis is suggested by these observations." 01/01/1998 - "These studies provide additional evidence for the role of tannin in the occupational lung disease byssinosis." 01/01/1995 - "The role of Ca2+ was investigated in the response of alveolar macrophages to cotton tannin, an agent implicated in the lung disease byssinosis in textile mill workers. " 01/01/1988 - "Cotton bract tannin: a novel human T-lymphocyte mitogen and a possible causative agent of byssinosis."
9.	LipopolysaccharidesIBA 01/01/1991 - "Byssinosis, a lung disease that can affect cotton mill workers, may be caused in part by lipopolysaccharides (LPS) from Gram negative bacteria. " 01/01/1985 - "Comparative in vivo and in vitro studies were made on bacterial lipopolysaccharide (LPS) and the chemotactic peptide NF-Met-Leu-Phe with a view toward studying their possible role in the pathophysiology of byssinosis. " 01/01/1985 - "Comparative toxicity studies between bacterial lipopolysaccharide (endotoxin) and N-formyl methionyl peptide as factors in the pathogenesis of byssinosis." 01/01/2003 - "Also, bacteria and fungi present in cotton do not in themselves cause byssinosis, but the endotoxins-heat-stable lipopolysaccharide-protein complexes contained in the cell wall of Gram-negative bacteria-are responsible for the development of this respiratory disease of workers on cotton, flax, and some other fibers. " 04/01/1988 - "Enterobacter agglomerans lipopolysaccharide-induced changes in pulmonary surfactant as a factor in the pathogenesis of byssinosis."
10.	Immunoglobulins (Immunoglobulin)IBA 07/01/1979 - "Discrimination between byssinosis and chronic bronchitis in cotton mill workers by serum immunoglobulin patterns." 04/01/1978 - "Immunoglobulins in byssinosis, chronic bronchitis and pulmonary eosinophilia." 01/01/1974 - "Immunology of byssinosis: a study of the reactions between the isolated byssinosis "antigen" and human immunoglobulins." 11/01/1985 - "Byssinosis: serum immunoglobulin and complement concentrations in cotton mill workers."

Therapies and Procedures

1.	Bandages (Bandage) 01/01/1965 - "[Studies on the incidence and etiology of byssinosis in the "Niva" (cotton and bandage factory of Novi Sad)]."
2.	Humidifiers 05/01/1994 - "Airborne endotoxins play a role in a variety of occupational diseases such as byssinosis and humidifier's disease and are associated with pulmonary and systemic symptoms. " 12/01/1980 - "Thus, human alveolar macrophages, like other mononuclear phagocytes, are extremely sensitive to endotoxin effects; these observations may be relevant in conditions in which endotoxin may be in contact with alveolar macrophages in vivo: endobronchial infections with gram-negative organisms, byssinosis, chronic bronchitis of grain handles, and humidifier fever."
3.	Nephrectomy 07/01/2012 - "We report a known case of Byssinosis who underwent nephrectomy under segmental spinal anesthesia at the low thoracic level. " 07/01/2012 - "Segmental thoracic spinal anesthesia in patient with Byssinosis undergoing nephrectomy."
4.	Spinal Anesthesia 07/01/2012 - "We report a known case of Byssinosis who underwent nephrectomy under segmental spinal anesthesia at the low thoracic level. " 07/01/2012 - "Segmental thoracic spinal anesthesia in patient with Byssinosis undergoing nephrectomy."