|1.||Darvesh, Sultan: 16 articles (07/2015 - 05/2002)|
|2.||Greig, Nigel H: 10 articles (01/2014 - 01/2002)|
|3.||Martin, Earl: 9 articles (07/2013 - 08/2004)|
|4.||Lane, Roger: 9 articles (08/2009 - 08/2005)|
|5.||Gao, Yang: 8 articles (08/2015 - 01/2013)|
|6.||Brimijoin, Stephen: 8 articles (08/2015 - 01/2013)|
|7.||Darreh-Shori, Taher: 8 articles (01/2015 - 04/2008)|
|8.||Nordberg, Agneta: 8 articles (11/2013 - 05/2007)|
|9.||Lockridge, Oksana: 8 articles (06/2013 - 04/2006)|
|10.||Wyse, Angela T S: 7 articles (08/2015 - 09/2003)|
|1.||Alzheimer Disease (Alzheimer's Disease)
05/20/1999 - "As our structure-activity studies predicted, these compounds are highly potent and selective inhibitors of human butyrylcholinesterase (BChE) and will test the novel hypothesis that BChE inhibitors are useful in the treatment of Alzheimer's disease. "
01/01/2015 - "Although many studies have estimated the association between the butyrylcholinesterase (BCHE) K variant and Alzheimer's disease (AD) risk, the results are still controversial. "
11/23/2004 - "Recent studies indicate that there is a synergic association between butyrylcholinesterase-K variant (BChE-K) and apolipoproteinE-epsilon 4 (ApoE-epsilon 4) to promote risk for Alzheimer's disease (AD). "
08/01/2004 - "Polymorphisms of the butyrylcholinesterase gene (BCHE) are reported to associate with Alzheimer's disease and a recent study found a significant association of the BCHE K variant (G1615A/Ala539Thr) with Type 2 diabetes. "
05/01/1999 - "This study attempted to corroborate findings on the association between butyrylcholinesterase K variant and Alzheimer's disease. "
11/01/2015 - "A novel expression cassette delivers efficient production of exclusively tetrameric human butyrylcholinesterase with improved pharmacokinetics for protection against organophosphate poisoning."
10/01/2010 - "While current therapies are only capable of reducing mortality, elevation of the serum levels of the related enzyme butyrylcholinesterase (BChE) by application of the purified protein as a bioscavenger of organophosphorous compounds is effective in preventing all symptoms associated with poisoning by these toxins. "
04/01/2001 - "Neuroparalysis and oxime efficacy in organophosphate poisoning: a study of butyrylcholinesterase."
11/01/2015 - "Butyrylcholinesterase is a stoichiometric bioscavenger against poisoning by organophosphorus pesticides and nerve agents. "
11/01/2011 - "Benefits of butyrylcholinesterase reactivability testing in organophosphate poisoning."
|3.||Cocaine-Related Disorders (Cocaine Addiction)
07/16/2014 - "In continuing efforts to develop gene transfer of human butyrylcholinesterase (BChE) as therapy for cocaine addiction, we conducted wide-ranging studies of physiological and metabolic safety. "
08/01/2015 - "Butyrylcholinesterase (BChE) gene therapy is emerging as a promising concept for treatment of cocaine addiction. "
01/01/2013 - "Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes."
07/11/2005 - "Increasing butyrylcholinesterase activity may be a treatment for cocaine addiction. "
05/01/2015 - "Safety, pharmacokinetics, and pharmacodynamics of TV-1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy subjects."
|4.||Body Weight (Weight, Body)
11/01/1983 - "In the present study, ganglionic butyrylcholinesterase was near-totally inactivated by the injection of tetramonoisopropyl pyyrophosphoramide (6.0 mumol/kg of body weight) intravenously. "
01/01/2010 - "The body weight and organs index were measured and the acetylcholinesterase and butyrylcholinesterase activity in brain were determined. "
09/01/2002 - "The paper describes the catalytic activity of butyrylcholinesterase (BuChE) measured in plasma, liver, white adipose tissue, heart, and brain of rats intraperitoneally administered a single non-lethal dose of cycloheximide (2.0 mg/kg body weight; CHM). "
01/01/1991 - "3. Ad libitum feeding of diets enriched with corn oil caused increased body weights in rabbits but not in rats 4. Plasma butyrylcholinesterase activities of rats were increased with increasing intakes of corn oil. "
05/01/2007 - "To assess the effect of coumaphos [O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl phosphorothioate] exposure on physiological responses during bovine production, acetylcolinesterase (AChE) and butyrylcholinesterase (BuChE) activities were measured in whole blood, erythrocytes, and plasma of healthy male steers (Bos Taurus x Bos indicus) sprayed with coumaphos at a non-lethal dose of 1 mg kg(- 1) body weight per day once every 14 (in vivo group) or 21 days (southern and central groups). "
05/01/2005 - "This finding is consistent with the suggestion that the K variant of butyrylcholinesterase has an important role in disease progression in AD, and this may have implications for treatment."
01/01/2005 - "These accumulating data suggest that butyrylcholinesterase contributes to disease progression in people with dementia, which may be particularly important in individuals with more severe dementia as butyrylcholinesterase activity increases with disease development. "
04/01/2002 - "Initial research focused upon acetylcholinesterase (AChE)-selective agents, but it is now thought that dual inhibitors of AChE and butyrylcholinesterase (BuChE) may provide more sustained efficacy over the course of AD and may help to slow disease progression. "
06/01/2002 - "New research suggests that rivastigmine, a potent, pseudo-irreversible inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase that shows preferential selectivity for the G1 form of AChE, may provide symptomatic and disease progression slowing effects. "
|3.||Cocaine (Cocaine HCl)
|6.||Phosphoric Acid Esters (Organophosphates)
|2.||Continuous Positive Airway Pressure
|5.||Palliative Care (Palliative Medicine)