|1.||Wounds and Injuries (Trauma)
|1.||Herndon, David N: 223 articles (12/2015 - 01/2002)|
|2.||Jeschke, Marc G: 86 articles (06/2015 - 05/2002)|
|3.||Wolf, Steven E: 83 articles (11/2015 - 01/2002)|
|4.||Traber, Daniel L: 71 articles (05/2014 - 11/2002)|
|5.||Enkhbaatar, Perenlei: 65 articles (12/2015 - 03/2003)|
|6.||Gamelli, Richard L: 63 articles (01/2016 - 06/2002)|
|7.||Tompkins, Ronald G: 61 articles (05/2015 - 01/2002)|
|8.||Greenhalgh, David G: 60 articles (01/2016 - 01/2002)|
|9.||Kovacs, Elizabeth J: 54 articles (11/2015 - 04/2002)|
|10.||Finnerty, Celeste C: 53 articles (12/2015 - 09/2005)|
|1.||Silver Sulfadiazine (SSD)FDA LinkGeneric
09/01/2001 - "Myth: silver sulfadiazine is the best treatment for minor burns."
04/01/1979 - "It was concluded that the exposure technique, with topical "Flamazine", was beneficial in the treatment of superficial burns, obviating the routine daily bathing of the burnt."
01/01/2015 - "In-vivo study demonstrated that a niosomal gel containing 0.5% w/w SSD was more effective in burn wound healing compared to 1% w/w marketed cream even when applied once a day. "
02/01/2001 - "The results of this study confirm the greater efficacy of SSD-CN in the treatment of burns patients."
12/01/2012 - "SSD has been widely used in acute cutaneous lesions, particularly in burns, where it is considered the "gold standard" by which other treatments are measured. "
02/01/2016 - "Total corneal thickness of all dogs post-burn was significantly greater than baseline OCT images irrespective of treatment (p = 0.004); TEM showed that alkali burned corneas had significantly greater minimum and maximum interfibrillar distances than the controls (p = 0.026, p = 0.018). "
01/01/2014 - "We successfully extracted mesenchymal stem cells (MSCs) from human AM, but little is known about the use and efficacy of human amniotic membrane-derived mesenchymal stem cells (hAM-dMSCs) for the treatment of alkali burns. "
04/01/1998 - "Broad applications may prove beneficial in the clinical treatment of corneal abrasions, persistent corneal epithelial defects, or alkali burns."
04/01/2012 - "[Comparative evaluation of therapeutic efficacy of early amnion covering the cornea, temporary blepharorrhaphy and its combination in severe alkali burns of the eye in the experiment]."
03/01/2010 - "A corneal alkali burn model in rats was used to evaluate the therapeutic efficacy of GB1201. "
01/01/2013 - "Although silver dressings are the gold standard for burn care in Australasia, very few high-level trials have been conducted that compare silver dressings to determine which will provide the best level of care clinically. "
04/01/2015 - "The silver-impregnated foam dressing is effective and safe for use in partial-thickness paediatric burns, eliminating the need for daily dressings. "
04/01/2015 - "The silver-impregnated foam dressing is effective and safe for use in partial-thickness paediatric burns, eliminating the need for daily dressings."
07/01/1981 - "The efficacy of FPQC and FPQC silver in vivo may represent discovery of new agents of known low toxicity that are useful in topical burn therapy."
12/01/1998 - "Physico-chemical, pharmacological and microbiological data explaining the antimicrobial efficacy of silver in prophylaxis of implants are presented here, as well as the scientific background for the established clinical benefits of silver-preparations in burns."
|4.||Anti-Bacterial Agents (Antibiotics)IBA
10/01/1987 - "Neither enteral antibiotics nor endotoxin binding agents were able to induce a significant reduction in the post-burn hypermetabolic response in this model."
03/01/2003 - "Despite judicious use of topical and systemic antibiotics, opportunistic nosocomial bacterial resistance threatens to annul the improved survival of patients with severe burns. "
03/20/1980 - "[In-vitro efficacy of topical antibiotics on bacteria from burns]."
02/01/2014 - "To study the distribution characteristics of pathogens, the drug resistance of Pseudomonas aeruginosa (PA), and the use of antibiotics against Gram negative bacilli (GNB) in burn wards, so as to provide a guide for future treatment. "
01/01/2014 - "This study aimed to analyze the spectrum and drug resistance of bacteria isolated from burn patients to provide a reference for rational clinical use of antibiotics. "
|5.||Insulin (Novolin)FDA Link
05/01/2012 - "Computerized insulin infusion programs are safe and effective in the burn intensive care unit."
04/01/2012 - "To investigate the protective effects of insulin on burn serum-challenged cardiocyte apoptosis and its mechanism. "
04/01/2012 - "[The protective effects of insulin on cardiocyte apoptosis challenged by burn serum]."
08/01/2010 - "However, to date no prospective randomized study exists that determines whether intensive insulin therapy is associated with improved post-burn morbidity and mortality. "
08/01/2010 - "To determine whether intensive insulin therapy is associated with improved post-burn morbidity. "
01/01/2008 - "Direct comparison between animals injured by 40% TBSA burn and 2 x 30 sec smoke exposure and sacrificed after 48 h showed significantly greater abnormality in the C57BL/6 mice. "
07/01/2006 - "PaCO2 was significantly greater in VCMV group at 36, 48, and 72 hours after smoke and burn injury. "
07/01/2006 - "Survival 84 hours after smoke and burn injury was significantly greater in the HFPV (7/7, 100%) compared with the VCMV group (3/6, 50%, P < .05). "
09/01/2003 - "The mean degree of bronchial, bronchiolar, and terminal bronchiolar obstruction was significantly greater in animals with smoke injury alone or combined smoke inhalation and burn (S+B) injury, compared with animals with burn injury alone or uninjured animals (P < 0.05). "
01/01/1989 - "Burn patients exhibited a significant reduction in serum Cu, although concomitant smoke inhalation increased serum Cu back to low-normal levels. "
09/30/2005 - "We are convinced that collagen sheets are very useful in first- and second-degree burns. "
01/01/2002 - "To investigate the efficacy of antioxidant therapy on collagen synthesis in corrosive esophageal burns, 110 Sprague-Dawley rats were divided into five groups of 22 animals each. "
06/01/2013 - "In contrast to previous studies that were performed using excised tissue specimens ex vivo, in vivo observation of dermal collagen fibers in living rat burn models with SHG microscopy is demonstrated. "
05/01/2008 - "In this study, we show that in vivo, pericytes in human granulation tissue taken from burn patients expressed CD13 and collagen I, which are cell markers of peripheral blood fibrocytes (PBFCs). "
01/01/2007 - "The aim of this study is to propose the use of human keratinocytes cultured on collagen matrix as an in vitro experimental burn model. "
|8.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/15/1996 - "Therapy with anti-TNF antibody at 1 x 10(4) neutralizing units (n.u.) kg-1 markedly improved outcome if given when TNF-alpha production was elevated at Day 7 after the burn (survival, 36%; P = 0.01) but did not improve survival when administered at Days 0 or 4 or at the time of the septic challenge (Day 10). "
09/01/2007 - "The results showed TNF-alpha concentrations were significantly greater in the burn limbs group when compared with the control limbs group (P < .05). "
10/01/1998 - "TNF-alpha produced diastolic and systolic [Ca2+]i values (1.067 +/- .023/1.301 +/- .017) that were similar to values seen after myocyte exposure to burn plasma (1.099 +/- .024/1.307 +/- .028) and significantly greater than values measured in controls (.857 +/- .017/1.077 +/- .015, p < .05). "
02/01/2008 - "Studies were designed to determine the time course of the induction of p38MAPK, TNF-alpha and myocardial apoptosis after burn injury. "
01/01/2006 - "Studies suggest that tumor necrosis factor alpha (TNF-alpha) plays a role in burn pathogenesis. "
01/01/2003 - "Mesenteric oxygen supply and consumption showed a significant reduction after burn. "
08/01/2015 - "This study evaluated the effects of a Topical Oxygen Emulsion (TOE) on burn wound healing. "
01/01/2015 - "The risk of burn injury during long-term oxygen therapy: a 17-year longitudinal national study in Sweden."
09/01/2013 - "Studies investigating hyperbaric oxygen treatment (HBOT) to improve outcome in burns have been inconclusive. "
02/01/2005 - "Therefore, in this study, we tested the hypothesis that alcohol ingestion before burn injury reduces splanchnic blood flow and oxygen delivery. "
11/01/2006 - "WE/G within 30 minutes after burn injury reduced myocyte secretion of proinflammatory cytokines and improved left ventricular pressure and +/-dP/dt responses to inotropic challenge. "
01/01/2015 - "This study was conducted to assess early changes in the serum levels of inflammatory cytokines after burn injury, identify cytokines associated with mortality, and characterize correlations among cytokines. "
06/01/2010 - "Therefore, the aim of this study was to determine the time course and prognostic value of pro- and anti-inflammatory cytokines in the immediate post-burn period. "
01/01/2009 - "This is a prospective clinical study focusing on cytokine inhibitors (sTNFR I, sTNFR II, IL-1ra) and anti-inflammatory cytokines (IL-10, IL-13) following burn injury in children. "
08/01/2001 - "Previous studies suggest that CD8(+) T cells are immunosuppressive after burn injury, but recent reports indicate that CD8(+) T cells have several functions similar to CD4(+) T cells, including the secretion of cytokines. "
05/01/2003 - "It still must be proven whether the exactly measured ITBV obtained from transcardiopulmonary double-indicator dilution is superior to the commonly used parameters to guide major burn resuscitation."
02/01/2009 - "The results of this study indicates that early use of GSH may be beneficial in the management of protecting hepatic injury after delayed resuscitation for severe burn."
04/01/2014 - "All parameters in NR group kept on worsening till death, while hemodynamic and organ functions of two intravenous resuscitation groups were gradually improved, CI, SVR and DAO in RP group were significantly superior to those of RL group from 2 hours on after burn (all P<0.05), and dp/dt max and CK-MB in RP group were significantly better than those of RL group from 6 hours on after burn (dp/dt max: 1,082.33±63.59 mmHg/s vs. 1,018.60±47.36 mmHg/s, CK-MB: 7,898.70±255.74 U/L vs. 8,438.70±442.00 U/L, all P<0.05), and MAP was significantly better than that of RL group at 6 hours (124.67±9.39 mmHg vs. 114.33±9.16 mmHg, P<0.05), and Cr was significantly better than that of RL group from 24 hours on after burn (53.42±4.99 μmol/L vs. 60.77±3.11 μmol/L, P<0.05). "
03/31/2009 - "Mortality as the primary endpoint was 16% in group 1 and 9% in group 2. Giving the smallest amount of fluids necessary for adequate resuscitation can be effective in creating a successful and specific therapy for all burn patients. "
10/01/1996 - "Resuscitation using HTS was associated with rapid improvement in organ tissue perfusion in anesthetized rats subjected to burn injury. "
11/01/2003 - "The technique is versatile, safe, simple, reliable and inexpensive, and has proven to be effective in over 700 burn patients, with 18 patients (2%) requiring repeat grafts. "
01/01/2013 - "Split-skin grafts have been utilised successfully to resurface full thickness burns of the penis and have given good results. "
05/15/2004 - "Immunohistochemical staining of all axons innervating the dermis and epidermis revealed a significant reduction in burn-graft relative to control skin (54% decrease, P < 0.0001). "
07/01/1997 - "Median flow values in nongrafted hands were 150 mV; in those requiring skin grafts, median flow values were 89 mV. Flow values were significantly greater in nongrafted compared with grafted hand burns on days 1 and 5. Volume values were not associated with whether or not grafting was performed. "
02/01/1975 - "Simplicity, improved hemostasia, good graft take, and the absence of special anesthetic requirements make this method particularly applicable to the management of patients with burn injury."
|3.||Skin Transplantation (Skin Grafting)
05/01/2015 - "The authors relate their results of a complex hair-bearing reconstruction of a scalp and brow defect after a friction road burn with those reported in literature, concluding that a 3-staged reconstruction (dermal template implantation, skin grafting, and finally hair micrografting) can achieve good results in this complex kind of reconstruction. "
05/01/2009 - "At this burn center, three patients with penile shaft burns have been treated successfully with Integra followed by thin, split-thickness skin grafting. "
04/27/2003 - "Intermingled skin grafting using autologous skin islets inlaid in allogeneic skin sheets was found to delay graft rejection, contributing to a significant reduction in mortality for patients with severe burns. "
01/01/1991 - "The use of cultured human epithelium for skin grafting has recently been developed and used successfully to treat burns and various smaller skin defects. "
12/01/1999 - "Early tangential excision and skin grafting of moderate burns is superior to honey dressing: a prospective randomised trial."
12/01/1999 - "Grid laser using threshold-level burns, in contrast, appeared to produce some improvement in thresholded high-contrast vision at eccentricities from 2 degrees to 3 degrees outward, but failed to normalize visual parameters at these intercepts or at intercepts closer to fixation. "
01/01/1990 - "The elaboration of rational therapeutic tactics, improvement of preoperative management, and the introduction of effective methods of treatment into practice with the use of microsurgical and laser techniques improved considerably the results of restorative operations on the esophagus in patients with combined burn pathology."
04/01/2009 - "This study was designed to assess and compare the efficacy of accelerating burn healing in diabetic rats using low-power visible and invisible lasers. "
03/01/2014 - "The validity of burn size assessment was calculated using live assessment as the gold standard, and of burn depth using clinical assessment in combination with laser Doppler imaging as the gold standard. "
11/01/2012 - "Laser Doppler Imaging (LDI) techniques allow an improved burn depth assessment but their use is limited by the time-consuming image acquisition which may take up to 6 min per image. "
09/15/1984 - "Burns resolved completely within 48 hours after debridement and patching."
01/01/2015 - "Those with pavement burns had a significantly greater requirement for operative intervention, repetitive debridements, overall cost/percent burned, and lengthier hospital stays than those with flame/scald burns. "
10/01/1995 - "The results suggest that in addition to its documented efficacy in the debridement of burn eschar, Vibriolysin may have beneficial effects on dermal reparative events."
12/01/2004 - "Safety and efficacy of a proteolytic enzyme for enzymatic burn debridement: a preliminary report."
12/01/2002 - "Prognosis in patients with severe burns is improved by early debridement and coverage with skin. "