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Buprenorphine (Subutex)

A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
Also Known As:
Subutex; Buprenex; 6029-M; Buprenorphine Hydrochloride; Buprex; Prefin; RX-6029-M; Temgesic; Temgésic; 6029 M; 6029M; Hydrochloride, Buprenorphine; RX 6029 M; RX6029M; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-
Networked: 4211 relevant articles (508 outcomes, 699 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Ling, Walter: 41 articles (06/2022 - 04/2003)
2. Fiellin, David A: 39 articles (11/2022 - 01/2002)
3. Gordon, Adam J: 30 articles (12/2022 - 10/2007)
4. Saxon, Andrew J: 26 articles (12/2022 - 01/2005)
5. Cunningham, Chinazo O: 26 articles (01/2022 - 05/2006)
6. Saloner, Brendan: 25 articles (12/2022 - 06/2017)
7. Stein, Bradley D: 25 articles (12/2022 - 06/2012)
8. Lintzeris, Nicholas: 24 articles (03/2022 - 02/2002)
9. O'Grady, Kevin E: 24 articles (12/2019 - 07/2005)
10. Jones, Hendrée E: 23 articles (01/2021 - 01/2006)

Related Diseases

1. Opioid-Related Disorders (Opiate Addiction)
2. Pain (Aches)
3. Postoperative Pain
4. Substance Withdrawal Syndrome (Withdrawal Symptoms)
5. Chronic Pain

Related Drugs and Biologics

1. Opioid Analgesics (Opioids)
2. Methadone (Dolophine)
3. Analgesics (Analgesic Drugs)
4. Morphine (MS Contin)
5. Fentanyl (Sublimaze)
6. Naltrexone (ReVia)
7. Naloxone Drug Combination Buprenorphine
8. Naloxone (Narcan)
9. Tramadol (K315)
10. Tablets

Related Therapies and Procedures

1. Therapeutics
2. Analgesia
3. Injections
4. Drug Therapy (Chemotherapy)
5. Transdermal Patch