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Bundle-Branch Block (Fascicular Block)

A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BUNDLE OF HIS thus preventing the simultaneous depolarization of the two ventricles.
Also Known As:
Fascicular Block; Anterior Fascicular Block; Bundle Branch Block; Left Bundle-Branch Block; Posterior Fascicular Block; Right Bundle-Branch Block; Anterior Fascicular Blocks; Block, Anterior Fascicular; Block, Bundle Branch; Block, Bundle-Branch; Block, Fascicular; Block, Left Bundle-Branch; Block, Posterior Fascicular; Block, Right Bundle-Branch; Blocks, Anterior Fascicular; Blocks, Bundle Branch; Blocks, Bundle-Branch; Blocks, Fascicular; Blocks, Left Bundle-Branch; Blocks, Posterior Fascicular; Blocks, Right Bundle-Branch; Branch Block, Bundle; Branch Blocks, Bundle; Bundle Branch Blocks; Bundle-Branch Block, Left; Bundle-Branch Block, Right; Bundle-Branch Blocks; Bundle-Branch Blocks, Left; Bundle-Branch Blocks, Right; Fascicular Block, Anterior; Fascicular Block, Posterior; Fascicular Blocks; Fascicular Blocks, Anterior; Fascicular Blocks, Posterior; Left Bundle Branch Block; Left Bundle-Branch Blocks; Posterior Fascicular Blocks; Right Bundle Branch Block; Right Bundle-Branch Blocks
Networked: 2054 relevant articles (96 outcomes, 219 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Heart Failure
2. Coronary Artery Disease (Coronary Atherosclerosis)
3. Left Ventricular Dysfunction
4. Ventricular Tachycardia
5. Cardiomyopathies (Cardiomyopathy)

Experts

1. McNitt, Scott: 43 articles (01/2021 - 04/2005)
2. Zareba, Wojciech: 40 articles (01/2021 - 04/2005)
3. Kutyifa, Valentina: 38 articles (01/2022 - 03/2013)
4. Moss, Arthur J: 35 articles (01/2019 - 04/2005)
5. Prinzen, Frits W: 34 articles (01/2022 - 10/2002)
6. Goldenberg, Ilan: 31 articles (01/2022 - 12/2011)
7. Vernooy, Kevin: 23 articles (03/2022 - 10/2002)
8. Solomon, Scott D: 19 articles (08/2021 - 06/2012)
9. Saba, Samir: 19 articles (06/2021 - 05/2010)
10. Varma, Niraj: 18 articles (01/2022 - 11/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bundle-Branch Block:
1. Thallium-201IBA
2. Dipyridamole (Persantine)FDA LinkGeneric
3. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
04/01/2005 - "New York Heart Association functional class IV, third heart sound, jugular vein congestion, cardiomegaly, radiological signs of lung oedema, pathological Q waves, left bundle branch block, sinus rhythm, ischaemic cardiopathy, and dilated cardiomyopathy were all significantly more prevalent in the group with deteriorated systolic function, as was treatment with angiotensin converting enzyme inhibitors and most other antihypertensive drugs on discharge from hospital. "
09/01/2022 - "Cardiac resynchronization therapy (CRT) was shown to improve cardiac function, reduce heart failure hospitalizations, improve quality of life and prolong survival in patients with severe left ventricular dysfunction and intraventricular conduction disturbances, mainly left bundle branch block, on optimal medical therapy with ACE-inhibitors, β-blockers and mineralocorticoid receptor antagonists up-titrated to maximum tolerated evidence-based doses. "
01/01/2023 - "A meta-regression revealed no association between death from any cause and left bundle branch block (LBBB), use of amiodarone, use of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers, year initiated enrollment, and the year ended enrollment (R2 = 0.0). "
01/01/2019 - "Previous work has demonstrated that treatment of hypertensive patients with the angiotensin-converting enzyme inhibitor lisinopril was associated with a reduced incidence of a composite conduction system disease endpoint and also left bundle branch block (LBBB) compared with chlorthalidone therapy. "
01/01/2023 - "Logistic regression probabilistically modelled non-response; variables included demographics, heart failure classification, left bundle branch block (LBBB), ischaemic heart disease (IHD), atrial fibrillation, QRS duration, baseline ejection fraction (EF) and LVESV, comorbidities, use of CRT optimization algorithm, angiotensin-converting enzyme inhibitor(ACE)/angiotensin-receptor blocker (ARB), beta-blocker, diuretics, and dp. "
4. Verapamil (Calan)FDA LinkGeneric
5. DobutamineFDA LinkGeneric
6. Dichlorodiphenyldichloroethane (DDD)IBA
7. Adenosine (Adenocard)FDA LinkGeneric
8. Lidocaine (Xylocaine)FDA LinkGeneric
9. Radioisotopes (Radionuclides)IBA
10. pro-brain natriuretic peptide (1-76)IBA
04/01/2016 - "Left bundle branch block patients with longer RV-LV activation delay at CRT implantation had greater improvement in NT-proBNP, EF, and significantly better clinical outcome."
04/01/2015 - "In univariable logistic regression, factors associated with R2 were age (p=0.02), non-ischemic etiology of HF (p<0.001), NYHA functional class (p=0.02), baseline LVEF (p=0.005), absence of left bundle branch block (LBBB; p=0.002), ST2 (p=0.004), NT-proBNP (p=0.005), and hs-cTnT (p<0.001); HF duration achieved borderline significance (p=0.08). "
06/01/2001 - "E/A ratio inversely correlated with plasma NT-proBNP concentration in patients with left bundle branch block (r=-0.48, P=0.02). "
05/01/2022 - "Multiple logistic regression analysis identified abnormal Q waves (odds ratio [OR]: 4.36; P = 0.003), cardiomegaly (OR: 3.32; P < 0.001), right bundle branch block (OR: 2.84; P = 0.011), cognitive dysfunction (OR: 2.14; P = 0.027) and NT-proBNP (OR 5.43; P < 0.001) as independent predictors of LVEF < 50%. "
01/01/2009 - "The cardiac findings were placed into 6 groups which were associated with an increase in NT-proBNP in the following order: (1) left ventricular hypertrophy [regression coefficient (beta) = 0.33, p = 0.03]; (2) exercise-induced myocardial ischemia (beta = 0.73, p = 0.02);(3) valvular or congenital heart disease or pericardial effusion (beta = 0.93, p < 0.0001); (4) pulmonary hypertension (beta = 1.14, p < 0.0001); (5) atrial fibrillation or left bundle branch block (beta = 1.22, p < 0.0001), and (6) left ventricular systolic dysfunction (beta = 1.94, p < 0.0001). "

Therapies and Procedures

1. Cardiac Resynchronization Therapy
2. Therapeutics
3. Defibrillators (Defibrillator)
4. Catheter Ablation
5. Transcatheter Aortic Valve Replacement