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Buformin

An oral hypoglycemic agent that inhibits gluconeogenesis, increases glycolysis, and decreases glucose oxidation.
Also Known As:
1-Butylbiguanide; Adebit; Gliporal; Silubin; Silubin Retard; 1 Butylbiguanide; Retard, Silubin; Butylbiguanide; Imidodicarbonimidic diamide, N-butyl-
Networked: 82 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Anisimov, Vladimir N: 4 articles (01/2016 - 01/2003)
2. Hirano, Kazuyuki: 3 articles (07/2009 - 08/2005)
3. Usui, Shigeyuki: 3 articles (07/2009 - 08/2005)
4. Castaño, Justo P: 2 articles (01/2021 - 01/2019)
5. Fuentes-Fayos, Antonio C: 2 articles (01/2021 - 01/2019)
6. Gahete, Manuel D: 2 articles (01/2021 - 01/2019)
7. Luque, Raúl M: 2 articles (01/2021 - 01/2019)
8. Chen, Ling: 2 articles (10/2018 - 01/2018)
9. Liu, Qiuli: 2 articles (10/2018 - 01/2018)
10. Tang, Mei: 2 articles (10/2018 - 01/2018)

Related Diseases

1. Neoplasms (Cancer)
2. Carcinogenesis
06/01/2015 - "Effects of metformin, buformin, and phenformin on the post-initiation stage of chemically induced mammary carcinogenesis in the rat."
06/01/2015 - "In this study, the effects of clinically relevant doses of metformin (9.3 mmol/kg diet), buformin (7.6 mmol/kg diet), and phenformin (5.0 mmol/kg diet) were compared with rats fed control diet (AIN93-G) during the post-initiation stage of 1-methyl-1-nitrosourea-induced (50 mg/kg body weight) mammary carcinogenesis (n = 30/group). "
01/01/2016 - "In the 70-80th of last century, it has been shown that the antidiabetic biguanide drugs phenformin (PF) and buformin (BF) can exert an inhibitory action on carcinogenesis in animal models and increase from 5 to 10-years survival of cancer patients. "
11/24/2015 - "The analysis of the available data have shown that the efficacy of cancer preventive effect of metformin (MF) and another biguanides, buformin (BF) and phenformin (PF), has been studied in relation to total tumor incidence and to 17 target organs, in 21 various strains of mice, 4 strains of rats and 1 strain of hamsters (inbred, outbred, transgenic, mutant), spontaneous (non- exposed to any carcinogenic agent) or induced by 16 chemical carcinogens of different classes (polycycIic aromatic hydrocarbons, nitroso compounds, estrogen, etc.), direct or indirect (need metabolic transformation into proximal carcinogen), by total body X-rays and γ- irradiation, viruses, genetic modifications or special high fat diet, using one stage and two-stage protocols of carcinogenesis, 5 routes of the administration of antidiabetic biguanides (oral gavage, intraperitoneal or subcutaneous injections, with drinking water or with diet) in a wide ranks of doses and treatment regimens. "
3. Human Influenza (Influenza)
4. Hypoglycemia (Reactive Hypoglycemia)
5. Insulin Resistance

Related Drugs and Biologics

1. Phenformin (Fenformin)
2. Biguanides
3. Metformin (Glucophage)
4. Hypoglycemic Agents (Hypoglycemics)
5. Glucose (Dextrose)
6. Carcinogens
7. Blood Glucose (Blood Sugar)
8. Drinking Water
9. Nitroso Compounds
10. Aromatic Hydrocarbons

Related Therapies and Procedures

1. Subcutaneous Injections
2. Cell Transplantation
3. Therapeutics
4. Drug Therapy (Chemotherapy)
5. Oral Administration