Bufanolides

Cyclopentanophenanthrenes with a 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. They are found in BUFONIDAE and often possess cardiotonic properties.

Also Known As:

Networked: 91 relevant articles (5 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ma, Hongyue: 7 articles (05/2019 - 01/2011)
2.	Zhou, Jing: 7 articles (05/2019 - 01/2012)
3.	Ye, Wen-Cai: 6 articles (11/2020 - 10/2012)
4.	Zhang, Dong-Mei: 6 articles (11/2020 - 10/2012)
5.	Duan, Jinao: 6 articles (05/2019 - 01/2012)
6.	Zhang, Junfeng: 6 articles (01/2015 - 01/2011)
7.	Liu, Jun-Shan: 5 articles (11/2020 - 10/2012)
8.	Tian, Hai-Yan: 5 articles (11/2020 - 10/2012)
9.	Zhan, Zhen: 5 articles (02/2013 - 01/2011)
10.	Deng, Li-Juan: 4 articles (11/2020 - 01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "This information is valuable for the prospective development of bufadienolides with improved pharmacological profiles as novel anti-tumor drugs. " 04/01/2019 - "Among 47 natural bufadienolides, most of bufadienolides (21 compounds isolated in this study and 26 compounds isolated previously) could significantly inhibit the proliferation of cancer cells, and compounds 1, 8, 12, 18 and 19 showed the most potent inhibitory activity against four types of human tumor cells. " 01/01/2011 - "To study the bioaffinity between 8 bufadienolides(Bu) and tumor cells and analyze the correlation between the bioaffinity and the anti-tumor activities of Bu. " 07/01/2023 - "However, the harsh physiological conditions of the gastrointestinal tract can cause the anti-cancer medicine bufadienolides (BU) to lose some of its structure, impairing its ability to fight cancer. " 03/01/2023 - "Besides, TSE-BJO NEs facilitated the long circulation of bufadienolides contributing to the high accumulation of drugs at tumor sites and the improvement of anti-tumor efficacy. "
2.	Stomach Neoplasms (Stomach Cancer) 04/21/2016 - "Here we report the potency and efficacy of a family of bufadienolides to inhibit the growth of gastric cancer cell line HGC-27 in three-dimensional (3D) spheroidal models. " 01/01/2017 - "Evaluation of Bufadienolides as the Main Antitumor Components in Cinobufacin Injection for Liver and Gastric Cancer Therapy." 04/21/2016 - "Anti-gastric cancer activity in three-dimensional tumor spheroids of bufadienolides." 03/01/2012 - "An antitumor study showed that bilirubin did not compromise the ability of bufadienolides to inhibit gastric cancer cell MGC-803 proliferation. " 01/01/2017 - "Bufadienolides are the most effective components in Cinobufacini injection for the treatment of liver and gastric cancers. "
3.	Ulcer 01/01/2014 - "Cinobufagin and resibufogenin are two major effective bufadienolides of Chan su (toad venom), which is a Chinese medicine obtained from the skin venom gland of toads and is used as a cardiotonic and central nervous system (CNS) respiratory agent, an analgesic and anesthetic, and as a remedy for ulcers. "
4.	Heart Block 02/01/2013 - "Although verapamil reduced the bufadienolide-induced ventricular arrhythmias, verapamil worsened heart block and lethal bradycardia of bufadienolides partly via increasing the uptake of bufadienolides in heart tissue, which could compromise the protective effects of verapamil against bufadienolide intoxication. "
5.	Bradycardia 02/01/2013 - "Although verapamil reduced the bufadienolide-induced ventricular arrhythmias, verapamil worsened heart block and lethal bradycardia of bufadienolides partly via increasing the uptake of bufadienolides in heart tissue, which could compromise the protective effects of verapamil against bufadienolide intoxication. "

Related Drugs and Biologics

1.	chan su (ChanSu)
2.	Amphibian Venoms
3.	bufogenin
4.	cinobufagin
5.	Cardiotonic Agents (Cardiac Stimulants)
6.	Venoms
7.	Antineoplastic Agents (Antineoplastics)
8.	Analgesics (Analgesic Drugs)
9.	bufadienolide
10.	Verapamil (Calan)

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Oral Administration
4.	Drug Therapy (Chemotherapy)
5.	Canes (Cane)